ID B5X3U1_SALSA Unreviewed; 197 AA.
AC B5X3U1;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Ganglioside GM2 activator {ECO:0000313|EMBL:ACI33972.1, ECO:0000313|RefSeq:NP_001133828.1};
GN Name=SAP3 {ECO:0000313|EMBL:ACI33972.1};
GN Synonyms=sap3 {ECO:0000313|RefSeq:NP_001133828.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ACI33972.1};
RN [1] {ECO:0000313|EMBL:ACI33972.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACI33972.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RA Leong J., von Schalburg K., Cooper G., Moore R., Holt R., Davidson W.S.,
RA Koop B.F.;
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACI33972.1, ECO:0000313|RefSeq:NP_001133828.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACI33972.1};
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
RN [3] {ECO:0000313|EMBL:ACI33972.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:ACI33972.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001133828.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BT045710; ACI33972.1; -; mRNA.
DR RefSeq; NP_001133828.1; NM_001140356.1.
DR STRING; 8030.ENSSSAP00000076674; -.
DR PaxDb; 8030-ENSSSAP00000076674; -.
DR GeneID; 100195327; -.
DR KEGG; sasa:100195327; -.
DR CTD; 100195327; -.
DR OrthoDB; 23272at2759; -.
DR Proteomes; UP000087266; Chromosome ssa05.
DR Bgee; ENSSSAG00000065677; Expressed in testis and 16 other cell types or tissues.
DR GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR GO; GO:0006689; P:ganglioside catabolic process; IEA:InterPro.
DR Gene3D; 2.70.220.10; Ganglioside GM2 activator; 1.
DR InterPro; IPR028996; GM2-AP.
DR InterPro; IPR036846; GM2-AP_sf.
DR InterPro; IPR003172; ML_dom.
DR PANTHER; PTHR17357:SF0; GANGLIOSIDE GM2 ACTIVATOR; 1.
DR PANTHER; PTHR17357; GM2 GANGLIOSIDE ACTIVATOR PROTEIN; 1.
DR Pfam; PF02221; E1_DerP2_DerF2; 1.
DR SMART; SM00737; ML; 1.
DR SUPFAM; SSF63707; Ganglioside M2 (gm2) activator; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001133828.1}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..197
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001133828.1"
FT /id="PRO_5009732130"
FT DOMAIN 39..191
FT /note="MD-2-related lipid-recognition"
FT /evidence="ECO:0000259|SMART:SM00737"
SQ SEQUENCE 197 AA; 21436 MW; FBE5FA2701276EED CRC64;
MKNCIVNVIM LCIVIQVNCA LAFEKTRTAY SAKIFGFSWE NCGKPDDPAV LKTLTVSPDP
ITVPGDLKAS ASGKTTVELA APLAVNVTLE KEVAGFWVKV PCVEEIGSCH YADGCDLLNQ
LIPPGQDCPE PLHTYGIPCH CPFKAGMYTL PESDFYLPDI ELPYWLTNGH YRVQGELGAM
GKELGCLKIT FAVHSNN
//
