ID B5X7R2_SALSA Unreviewed; 128 AA.
AC B5X7R2;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Receptor activity-modifying protein 1 {ECO:0000256|ARBA:ARBA00041071};
GN Name=RAMP1 {ECO:0000313|EMBL:ACI66882.1};
GN Synonyms=LOC106590732 {ECO:0000313|RefSeq:XP_014037365.1,
GN ECO:0000313|RefSeq:XP_014037366.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ACI66882.1};
RN [1] {ECO:0000313|EMBL:ACI66882.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Thymus {ECO:0000313|EMBL:ACI66882.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RA Leong J., von Schalburg K., Cooper G., Moore R., Holt R., Davidson W.S.,
RA Koop B.F.;
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACI66882.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Thymus {ECO:0000313|EMBL:ACI66882.1};
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
RN [3] {ECO:0000313|EMBL:ACI66882.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Thymus {ECO:0000313|EMBL:ACI66882.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:XP_014037365.1, ECO:0000313|RefSeq:XP_014037366.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014037365.1,
RC ECO:0000313|RefSeq:XP_014037366.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transports the calcitonin gene-related peptide type 1
CC receptor (CALCRL) to the plasma membrane. Acts as a receptor for
CC calcitonin-gene-related peptide (CGRP) together with CALCRL.
CC {ECO:0000256|ARBA:ARBA00037503}.
CC -!- SUBUNIT: Heterodimer of CALCRL and RAMP1.
CC {ECO:0000256|ARBA:ARBA00038839}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the RAMP family.
CC {ECO:0000256|ARBA:ARBA00007087}.
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DR EMBL; BT047081; ACI66882.1; -; mRNA.
DR RefSeq; XP_014037365.1; XM_014181890.1.
DR RefSeq; XP_014037366.1; XM_014181891.1.
DR STRING; 8030.ENSSSAP00000082996; -.
DR PaxDb; 8030-ENSSSAP00000024317; -.
DR GeneID; 106590732; -.
DR OrthoDB; 4193659at2759; -.
DR Proteomes; UP000087266; Unplaced.
DR Bgee; ENSSSAG00000068075; Expressed in muscle tissue and 8 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.150.510; Receptor activity modifying family; 1.
DR InterPro; IPR006985; RAMP.
DR InterPro; IPR038126; RAMP_sf.
DR PANTHER; PTHR14076; RECEPTOR ACTIVITY MODIFYING PROTEIN RAMP; 1.
DR PANTHER; PTHR14076:SF3; RECEPTOR ACTIVITY-MODIFYING PROTEIN 1; 1.
DR Pfam; PF04901; RAMP; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ACI66882.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 98..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 128 AA; 14551 MW; 8578918E1E196FBA CRC64;
MSTLPAAPWS NPYDAYDKIK DRTSCEWICG SPTRALMGFA MVTRPYEELT NCTFFVALKM
HCFWPNQLID ELFIHLHRDY FHDCALTGRL LQDPPIRILG PFIGVPVLVT LLMTALVVWS
GKCCQGIV
//
