ID B5XBD8_SALSA Unreviewed; 152 AA.
AC B5XBD8;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Calcineurin B homologous protein 3 {ECO:0000256|ARBA:ARBA00041032};
DE AltName: Full=Tescalcin {ECO:0000256|ARBA:ARBA00042981};
GN Name=TESC {ECO:0000313|EMBL:ACI68158.1};
GN Synonyms=tesc {ECO:0000313|RefSeq:NP_001134600.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:ACI68158.1};
RN [1] {ECO:0000313|EMBL:ACI68158.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pyloric caeca {ECO:0000313|EMBL:ACI68158.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RA Leong J., von Schalburg K., Cooper G., Moore R., Holt R., Davidson W.S.,
RA Koop B.F.;
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACI68158.1, ECO:0000313|RefSeq:NP_001134600.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pyloric caeca {ECO:0000313|EMBL:ACI68158.1};
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
RN [3] {ECO:0000313|EMBL:ACI68158.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pyloric caeca {ECO:0000313|EMBL:ACI68158.1};
RG cGRASP (B.F. Koop & W.S. Davidson);
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001134600.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cell projection, ruffle membrane {ECO:0000256|ARBA:ARBA00004632}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the calcineurin regulatory subunit family. CHP
CC subfamily. {ECO:0000256|ARBA:ARBA00038164}.
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DR EMBL; BT048357; ACI68158.1; -; mRNA.
DR RefSeq; NP_001134600.1; NM_001141128.1.
DR PaxDb; 8030-ENSSSAP00000020157; -.
DR GeneID; 100196099; -.
DR KEGG; sasa:100196099; -.
DR CTD; 54997; -.
DR OrthoDB; 4125954at2759; -.
DR Proteomes; UP000087266; Chromosome ssa20.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR46823; CALCINEURIN B HOMOLOGOUS PROTEIN 3; 1.
DR PANTHER; PTHR46823:SF2; CALCINEURIN B HOMOLOGOUS PROTEIN 3; 1.
DR Pfam; PF13405; EF-hand_6; 1.
DR SMART; SM00054; EFh; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 2: Evidence at transcript level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protein kinase inhibitor {ECO:0000256|ARBA:ARBA00023013};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 112..147
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 152 AA; 17432 MW; 62E96F6496D065B6 CRC64;
MGASQSAGTE HEFQDLADRT GFSLEQIGNI NKRFRQLSNN QETLSREDLA SIPALDNNPI
RAQIINAFFD KRNLHQNETG TVQEIGFEEF LMVMTHFRPA AMGLTEEERE NLRREKLRFL
FNMHDTDSDG TINLEEYRRV VEELLSKAGT IG
//
