ID MGRB_KLEP3 Reviewed; 47 AA.
AC B5XQ45;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=PhoP/PhoQ regulator MgrB {ECO:0000255|HAMAP-Rule:MF_01596};
GN Name=mgrB {ECO:0000255|HAMAP-Rule:MF_01596}; OrderedLocusNames=KPK_1949;
OS Klebsiella pneumoniae (strain 342).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=507522;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=342;
RX PubMed=18654632; DOI=10.1371/journal.pgen.1000141;
RA Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H.,
RA Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y.,
RA Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W.,
RA Methe B.A.;
RT "Complete genome sequence of the N2-fixing broad host range endophyte
RT Klebsiella pneumoniae 342 and virulence predictions verified in mice.";
RL PLoS Genet. 4:E1000141-E1000141(2008).
CC -!- FUNCTION: PhoP-regulated transcription is redox-sensitive, being
CC activated when the periplasm becomes more reducing. MgrB acts between
CC DsbA/DsbB and PhoP/PhoQ in this pathway. Represses PhoP/PhoQ signaling,
CC possibly by binding to the periplasmic domain of PhoQ, altering its
CC activity and that of downstream effector PhoP. {ECO:0000255|HAMAP-
CC Rule:MF_01596}.
CC -!- SUBUNIT: May form homooligomers. Probably interacts with the
CC periplasmic domain of PhoQ. {ECO:0000255|HAMAP-Rule:MF_01596}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01596}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01596}.
CC -!- SIMILARITY: Belongs to the MgrB family. {ECO:0000255|HAMAP-
CC Rule:MF_01596}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000964; ACI07312.1; -; Genomic_DNA.
DR AlphaFoldDB; B5XQ45; -.
DR KEGG; kpe:KPK_1949; -.
DR HOGENOM; CLU_208030_1_0_6; -.
DR Proteomes; UP000001734; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070298; P:negative regulation of phosphorelay signal transduction system; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01596; MgrB; 1.
DR InterPro; IPR020907; MgrB.
DR Pfam; PF13998; MgrB; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..47
FT /note="PhoP/PhoQ regulator MgrB"
FT /id="PRO_1000201570"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01596"
SQ SEQUENCE 47 AA; 5544 MW; 80E8468FD9D776F0 CRC64;
MKKLRWVLLI VIIAGCLLLW TQMLNVMCDQ DVQFFSGICT INKFIPW
//
