ID   B5Y654_COPPD            Unreviewed;       253 AA.
AC   B5Y654;
DT   25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT   25-NOV-2008, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   RecName: Full=Uridine phosphorylase {ECO:0000256|ARBA:ARBA00021980};
DE            EC=2.4.2.3 {ECO:0000256|ARBA:ARBA00011888};
GN   OrderedLocusNames=COPRO5265_1476 {ECO:0000313|EMBL:ACI16993.1};
OS   Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / OCM 4 /
OS   BT).
OC   Bacteria; Coprothermobacterota; Coprothermobacteria; Coprothermobacterales;
OC   Coprothermobacteraceae; Coprothermobacter.
OX   NCBI_TaxID=309798 {ECO:0000313|EMBL:ACI16993.1, ECO:0000313|Proteomes:UP000001732};
RN   [1] {ECO:0000313|Proteomes:UP000001732}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35245 / DSM 5265 / OCM 4 / BT
RC   {ECO:0000313|Proteomes:UP000001732};
RA   Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.;
RT   "The complete genome sequence of Coprothermobacter proteolyticus strain
RT   ATCC 5245 / DSM 5265 / BT.";
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACI16993.1, ECO:0000313|Proteomes:UP000001732}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35245 / DSM 5265 / OCM 4 / BT
RC   {ECO:0000313|Proteomes:UP000001732};
RX   PubMed=24831154;
RA   Alexiev A., Coil D.A., Badger J.H., Enticknap J., Ward N., Robb F.T.,
RA   Eisen J.A.;
RT   "Complete Genome Sequence of Coprothermobacter proteolyticus DSM 5265.";
RL   Genome Announc. 2:e00470-14(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=phosphate + uridine = alpha-D-ribose 1-phosphate + uracil;
CC         Xref=Rhea:RHEA:24388, ChEBI:CHEBI:16704, ChEBI:CHEBI:17568,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00001020};
CC   -!- SIMILARITY: Belongs to the PNP/UDP phosphorylase family.
CC       {ECO:0000256|ARBA:ARBA00010456}.
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DR   EMBL; CP001145; ACI16993.1; -; Genomic_DNA.
DR   AlphaFoldDB; B5Y654; -.
DR   STRING; 309798.COPRO5265_1476; -.
DR   KEGG; cpo:COPRO5265_1476; -.
DR   eggNOG; COG2820; Bacteria.
DR   Proteomes; UP000001732; Chromosome.
DR   GO; GO:0004850; F:uridine phosphorylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009164; P:nucleoside catabolic process; IEA:UniProt.
DR   CDD; cd17767; UP_EcUdp-like; 1.
DR   Gene3D; 3.40.50.1580; Nucleoside phosphorylase domain; 1.
DR   InterPro; IPR018016; Nucleoside_phosphorylase_CS.
DR   InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR   InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR   PANTHER; PTHR43691:SF11; FI09636P-RELATED; 1.
DR   PANTHER; PTHR43691; URIDINE PHOSPHORYLASE; 1.
DR   Pfam; PF01048; PNP_UDP_1; 1.
DR   SUPFAM; SSF53167; Purine and uridine phosphorylases; 1.
DR   PROSITE; PS01232; PNP_UDP_1; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000313|EMBL:ACI16993.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001732};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ACI16993.1}.
FT   DOMAIN          20..208
FT                   /note="Nucleoside phosphorylase"
FT                   /evidence="ECO:0000259|Pfam:PF01048"
SQ   SEQUENCE   253 AA;  27823 MW;  457E83459FDFC977 CRC64;
     MLETDLQPHI RLGRNQSANY ALLPGDPGRV KRIAAFLDDV EELVYNREFC SVRGKYKGVS
     VLIVSTGIGG PSTGIAVEEL NKTGVKTMIR IGSCGALQDN MKVGDLVIAQ AAVRDEGTSK
     TYIDPCYPAV PDPDVMFAIL KCARELNYRH HCGIIRSHDS FYTDRENEID NYWSERGVLA
     ADMETAALFV IGRLREVRTA SILNVVTEKT AILEQSINDY ASGERAAAMG EEREIKLALE
     TFAFLSGLEL SST
//