ID B5Y7M1_COPPD Unreviewed; 941 AA.
AC B5Y7M1;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN Name=uvrA {ECO:0000313|EMBL:ACI17354.1};
GN OrderedLocusNames=COPRO5265_0402 {ECO:0000313|EMBL:ACI17354.1};
OS Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / OCM 4 /
OS BT).
OC Bacteria; Coprothermobacterota; Coprothermobacteria; Coprothermobacterales;
OC Coprothermobacteraceae; Coprothermobacter.
OX NCBI_TaxID=309798 {ECO:0000313|EMBL:ACI17354.1, ECO:0000313|Proteomes:UP000001732};
RN [1] {ECO:0000313|Proteomes:UP000001732}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35245 / DSM 5265 / OCM 4 / BT
RC {ECO:0000313|Proteomes:UP000001732};
RA Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.;
RT "The complete genome sequence of Coprothermobacter proteolyticus strain
RT ATCC 5245 / DSM 5265 / BT.";
RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACI17354.1, ECO:0000313|Proteomes:UP000001732}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35245 / DSM 5265 / OCM 4 / BT
RC {ECO:0000313|Proteomes:UP000001732};
RX PubMed=24831154;
RA Alexiev A., Coil D.A., Badger J.H., Enticknap J., Ward N., Robb F.T.,
RA Eisen J.A.;
RT "Complete Genome Sequence of Coprothermobacter proteolyticus DSM 5265.";
RL Genome Announc. 2:e00470-14(2014).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
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DR EMBL; CP001145; ACI17354.1; -; Genomic_DNA.
DR RefSeq; WP_012544006.1; NC_011295.1.
DR AlphaFoldDB; B5Y7M1; -.
DR STRING; 309798.COPRO5265_0402; -.
DR KEGG; cpo:COPRO5265_0402; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_0_2_9; -.
DR OrthoDB; 9809851at2; -.
DR Proteomes; UP000001732; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd03271; ABC_UvrA_II; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001732};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 588..927
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 941 AA; 105708 MW; BE67E4982D503378 CRC64;
MEREIILRGV RHHNLKNLSL NIPREKFIVV TGISGSGKST LAFDVLYAEA HRRFIESLSG
YARMFLGIMQ KPDVDYIEGI PPAISVEQKT ASHNPRSIVG TVTEIYDYLR LLFAHVGVPY
CPEHRIPMLP VTVDEIVDRV LTNYAGERIY VLAPVVRGKK GEQKKLIEQI AKMGYTKVFL
DDILYDVDEP VEIDKNQRHT LEVVTDRLTV KAENRSRIAD AVEQAFKLAE GVVAITTEEG
KEYFSQQMAC PICGRTLPEL SPRLFSFNSP YGACEVCNGL GFQTKASEDL VVDHESPLLE
AIIPYRDNEF YQQMLHALAR EFHIDLKKPF KDLPEDVKEG ILRKGFGRVK LPIYLENGRE
IHVQFRPVLP EIERRIKETA SEDVFNWYYR YVEEVPCDAC GGARLRPEAL WVEIDGLNIY
QVSSMDFKHF LGWLESLHIT GARSQVAQPI MQELIKRVNF VVNIGLDYIQ VNRRMDTLSG
GEAQRVRLAS QLGSGLTGVL YVLDEPSIGL HSRDTERLVS ILRSLRDEGN TVVVVEHDND
IIESSDHVID LGPYAGKRGG EVVFQGSPEE LKKADTLTGQ YVSGRRQIQV TQKRRAPQGW
VRVQDASLNN LKHIDVGFPL GCFTVVTGVS GSGKSSLVID TLYKALENYQ SRRKVTSVRL
RNLEIQGDIK HTVLVDQSPI GRTPRSNPAT YTGVWTPIRE LFATLRESKE RGYKASRFSF
NVPSSRGGGR CEACKGEGQT KVEMALLPDV YVTCEVCGGK RFNKETLEVK YKGLSIADVL
ELTVDEALEV FENIPAIRRG LEVLQAVGLG YIELGQPAPT LSGGEAQRVK LATYLKSRAK
DYVFILDEPT TGLHSYDVEM LLQVLHKLVD QGNTVIVVEH NLDVVGNADY IVDLGPEGGD
EGGYVIFAGT PEELVKQEHS YTGQYLRLYW ERFKPQLILS H
//
