ID B5YJE6_THEYD Unreviewed; 446 AA.
AC B5YJE6;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Methyltransferase {ECO:0000256|RuleBase:RU362026};
DE EC=2.1.1.- {ECO:0000256|RuleBase:RU362026};
GN OrderedLocusNames=THEYE_A0518 {ECO:0000313|EMBL:ACI21948.1};
OS Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87).
OC Bacteria; Nitrospirota; Thermodesulfovibrionia; Thermodesulfovibrionales;
OC Thermodesulfovibrionaceae; Thermodesulfovibrio.
OX NCBI_TaxID=289376 {ECO:0000313|EMBL:ACI21948.1, ECO:0000313|Proteomes:UP000000718};
RN [1] {ECO:0000313|Proteomes:UP000000718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51303 / DSM 11347 / YP87
RC {ECO:0000313|Proteomes:UP000000718};
RA Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.;
RT "The complete genome sequence of Thermodesulfovibrio yellowstonii strain
RT ATCC 51303 / DSM 11347 / YP87.";
RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACI21948.1, ECO:0000313|Proteomes:UP000000718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51303 / DSM 11347 / YP87
RC {ECO:0000313|Proteomes:UP000000718};
RX PubMed=25635016;
RA Bhatnagar S., Badger J.H., Madupu R., Khouri H.M., O'Connor E.M.,
RA Robb F.T., Ward N.L., Eisen J.A.;
RT "Genome Sequence of the Sulfate-Reducing Thermophilic Bacterium
RT Thermodesulfovibrio yellowstonii Strain DSM 11347T (Phylum Nitrospirae).";
RL Genome Announc. 3:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:16857, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:13674,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:137933; EC=2.1.1.113;
CC Evidence={ECO:0000256|ARBA:ARBA00001893};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family. N(4)
CC subfamily. {ECO:0000256|ARBA:ARBA00010203}.
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DR EMBL; CP001147; ACI21948.1; -; Genomic_DNA.
DR RefSeq; WP_012546645.1; NC_011296.1.
DR RefSeq; YP_002248361.1; NC_011296.1.
DR AlphaFoldDB; B5YJE6; -.
DR STRING; 289376.THEYE_A0518; -.
DR REBASE; 18910; M.Tye11347ORF518P.
DR EnsemblBacteria; ACI21948; ACI21948; THEYE_A0518.
DR KEGG; tye:THEYE_A0518; -.
DR PATRIC; fig|289376.4.peg.512; -.
DR eggNOG; COG0863; Bacteria.
DR eggNOG; COG1525; Bacteria.
DR HOGENOM; CLU_634099_0_0_0; -.
DR InParanoid; B5YJE6; -.
DR OrthoDB; 9773571at2; -.
DR Proteomes; UP000000718; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IBA:GO_Central.
DR GO; GO:0015667; F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 2.40.50.90; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002941; DNA_methylase_N4/N6.
DR InterPro; IPR017985; MeTrfase_CN4_CS.
DR InterPro; IPR001091; RM_Methyltransferase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR PANTHER; PTHR13370:SF32; DNA ADENINE METHYLTRANSFERASE YHDJ; 1.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR Pfam; PF01555; N6_N4_Mtase; 1.
DR Pfam; PF00565; SNase; 1.
DR PRINTS; PR00508; S21N4MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF50199; Staphylococcal nuclease; 1.
DR PROSITE; PS00093; N4_MTASE; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ACI21948.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000718};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ACI21948.1}.
FT DOMAIN 23..254
FT /note="DNA methylase N-4/N-6"
FT /evidence="ECO:0000259|Pfam:PF01555"
FT DOMAIN 369..440
FT /note="TNase-like"
FT /evidence="ECO:0000259|Pfam:PF00565"
SQ SEQUENCE 446 AA; 52515 MW; 7B8C5402F6275114 CRC64;
MKTYHKIIIG DSRWMKEVAD ESVHLIVTSP PYWQLKDYGN GSQIGFNDTY EEYINNLNLV
WKECHRVLHK GCRLCINIGD QFARSVYYGR YKVIPIRTEI IKFCETIGFD YMGAIIWQKV
TTCNTTGGAT VMGSYPYPRN GILKLDYEFI LIFKKYGNPP KVSKEIKEKS KLTDEEWKQY
FTGHWNFSGE KQDKHLAMFP EELPKRLIKM FSFVGETVLD PFLGSGTTSL VARKLNRNSI
GYEINENFLS IIKEKLGITQ NSVFHDANFA VFNLFKRNDA HFEIMRQEKP TVDFKEEIKK
LPYIFKDPVK FERKVDPKKL RFGSKIDNSS YDRETYFTIK EIISPEMLIL NNGLKIKLLG
VRENLQKKEE AIQFLREKTK GQKVFIKFDN IKYDEENTLL CYLYLWNKTF LNAHLIKNGL
VDVDTNLHYK YKTKFLNLQR EIIRVV
//
