GenomeNet

Database: UniProt
Entry: B5YJW4
LinkDB: B5YJW4
Original site: B5YJW4 
ID   UVRB_THEYD              Reviewed;         671 AA.
AC   B5YJW4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   11-DEC-2019, entry version 71.
DE   RecName: Full=UvrABC system protein B {ECO:0000255|HAMAP-Rule:MF_00204};
DE            Short=Protein UvrB {ECO:0000255|HAMAP-Rule:MF_00204};
DE   AltName: Full=Excinuclease ABC subunit B {ECO:0000255|HAMAP-Rule:MF_00204};
GN   Name=uvrB {ECO:0000255|HAMAP-Rule:MF_00204}; OrderedLocusNames=THEYE_A0687;
OS   Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87).
OC   Bacteria; Nitrospirae; Nitrospirales; Nitrospiraceae; Thermodesulfovibrio.
OX   NCBI_TaxID=289376;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51303 / DSM 11347 / YP87;
RA   Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.;
RT   "The complete genome sequence of Thermodesulfovibrio yellowstonii strain
RT   ATCC 51303 / DSM 11347 / YP87.";
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. A damage recognition complex composed of 2
CC       UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of
CC       the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps
CC       around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB
CC       and probably causes local melting of the DNA helix, facilitating
CC       insertion of UvrB beta-hairpin between the DNA strands. Then UvrB
CC       probes one DNA strand for the presence of a lesion. If a lesion is
CC       found the UvrA subunits dissociate and the UvrB-DNA preincision complex
CC       is formed. This complex is subsequently bound by UvrC and the second
CC       UvrB is released. If no lesion is found, the DNA wraps around the other
CC       UvrB subunit that will check the other stand for damage.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SUBUNIT: Forms a heterotetramer with UvrA during the search for
CC       lesions. Interacts with UvrC in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- DOMAIN: The beta-hairpin motif is involved in DNA binding.
CC       {ECO:0000255|HAMAP-Rule:MF_00204}.
CC   -!- SIMILARITY: Belongs to the UvrB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00204}.
DR   EMBL; CP001147; ACI21236.1; -; Genomic_DNA.
DR   RefSeq; WP_012545956.1; NC_011296.1.
DR   RefSeq; YP_002248529.1; NC_011296.1.
DR   SMR; B5YJW4; -.
DR   STRING; 289376.THEYE_A0687; -.
DR   PRIDE; B5YJW4; -.
DR   EnsemblBacteria; ACI21236; ACI21236; THEYE_A0687.
DR   GeneID; 6942177; -.
DR   KEGG; tye:THEYE_A0687; -.
DR   PATRIC; fig|289376.4.peg.680; -.
DR   eggNOG; ENOG4105CCW; Bacteria.
DR   eggNOG; COG0556; LUCA.
DR   HOGENOM; HOG000073580; -.
DR   InParanoid; B5YJW4; -.
DR   KO; K03702; -.
DR   OMA; RYMHSEI; -.
DR   OrthoDB; 95696at2; -.
DR   BioCyc; TYEL289376:G1GCQ-686-MONOMER; -.
DR   Proteomes; UP000000718; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00204; UvrB; 1.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004807; UvrB.
DR   InterPro; IPR041471; UvrB_inter.
DR   InterPro; IPR024759; UvrB_YAD/RRR_dom.
DR   PANTHER; PTHR24029; PTHR24029; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF12344; UvrB; 1.
DR   Pfam; PF17757; UvrB_inter; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR00631; uvrb; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50151; UVR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair;
KW   Excision nuclease; Helicase; Hydrolase; Nucleotide-binding;
KW   Reference proteome; SOS response.
FT   CHAIN           1..671
FT                   /note="UvrABC system protein B"
FT                   /id="PRO_1000200559"
FT   DOMAIN          25..178
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00204"
FT   DOMAIN          435..601
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00204"
FT   DOMAIN          626..661
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00204"
FT   NP_BIND         38..45
FT                   /note="ATP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00204"
FT   MOTIF           91..114
FT                   /note="Beta-hairpin"
SQ   SEQUENCE   671 AA;  77318 MW;  3BCD754DBBF56720 CRC64;
     MGNFKIYTSF KPKGDQPKAI KQLVEGIKKG YKHQVLLGVT GSGKTFTIAN VIEKVNKPTL
     VIAHNKTLAA QLYGELKELF PYNAVEYYVS YYDYYQPEAY IPETDTYIEK DALINDDIDR
     MRHSATLSVL TRQDVIVVAS VSCIYGIGSP DDYMSMHVTL EEGMKTERDA MLKKLVEILY
     IRAEEEFRRG AFRVRGDVVD IFASHCLDKA YRVEFFDDEI DAIYEIDPLT GSRQKRLQRI
     FIPPNSHWVT PEPRLKKALE TIEEELQERI KYFKERGEEL FAERIEKRTR FDMELLSQFG
     HCHGIENYSR HLSGRLPGEP PFTLIDYIYA GPSKGDFLTV IDESHVTVPQ IGGMYEGDRS
     RKQTLVEYGF RLPSALDNRP LTFKEFEHRM NYVIYVSATP GDYEIEKSGG RIVEQIIRPT
     GLVDPKIEVR PATNQVEDLL EEIHKRVSRG ERVLVTTITK KMAEDLTDYY TTVGIKAKYL
     HSDIDTLERV EILKDLRLGK FDVLIGVNLL REGLDLPEVS LVAIFDADKE GFLRSERSLI
     QTAGRASRNI NGTVIFYADT VTDSMKKAIE ETERRREIQM KYNKKNGISP ETVKSKIKDI
     LSSIYEKDYV TVDVVKEEAE EYELNEETIK KLEQEMKHAA ENLEFEKAAE IRDKIFKIKE
     KMLKLGMKLT V
//
DBGET integrated database retrieval system