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Database: UniProt
Entry: B5ZCA9
LinkDB: B5ZCA9
Original site: B5ZCA9 
ID   KITH_UREU1              Reviewed;         223 AA.
AC   B5ZCA9;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   16-JAN-2019, entry version 57.
DE   RecName: Full=Thymidine kinase {ECO:0000255|HAMAP-Rule:MF_00124};
DE            EC=2.7.1.21 {ECO:0000255|HAMAP-Rule:MF_00124};
GN   Name=tdk {ECO:0000255|HAMAP-Rule:MF_00124};
GN   OrderedLocusNames=UUR10_0699;
OS   Ureaplasma urealyticum serovar 10 (strain ATCC 33699 / Western).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX   NCBI_TaxID=565575;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33699 / Western;
RA   Shrivastava S., Methe B.A., Glass J., White K., Duffy L.B.;
RT   "Genome sequence of Ureaplasma urealyticum serovar 10 ATCC-33699.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + thymidine = ADP + dTMP + H(+);
CC         Xref=Rhea:RHEA:19129, ChEBI:CHEBI:15378, ChEBI:CHEBI:17748,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216;
CC         EC=2.7.1.21; Evidence={ECO:0000255|HAMAP-Rule:MF_00124};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00124}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00124}.
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00124}.
DR   EMBL; CP001184; ACI59923.1; -; Genomic_DNA.
DR   RefSeq; WP_004025969.1; NC_011374.1.
DR   ProteinModelPortal; B5ZCA9; -.
DR   SMR; B5ZCA9; -.
DR   STRING; 565575.UUR10_0699; -.
DR   EnsemblBacteria; ACI59923; ACI59923; UUR10_0699.
DR   KEGG; uue:UUR10_0699; -.
DR   eggNOG; ENOG4107T8J; Bacteria.
DR   eggNOG; COG1435; LUCA.
DR   HOGENOM; HOG000076390; -.
DR   KO; K00857; -.
DR   OMA; KEQFGWI; -.
DR   OrthoDB; 1279539at2; -.
DR   BioCyc; UURE565575:G1GTT-684-MONOMER; -.
DR   Proteomes; UP000002018; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00124; Thymidine_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   InterPro; IPR020633; Thymidine_kinase_CS.
DR   PANTHER; PTHR11441; PTHR11441; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00603; TK_CELLULAR_TYPE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA synthesis; Kinase;
KW   Metal-binding; Nucleotide-binding; Transferase; Zinc.
FT   CHAIN         1    223       Thymidine kinase.
FT                                /FTId=PRO_1000095439.
FT   NP_BIND      19     26       ATP. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   NP_BIND      96     99       ATP. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   ACT_SITE     97     97       Proton acceptor. {ECO:0000255|HAMAP-
FT                                Rule:MF_00124}.
FT   METAL       153    153       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   METAL       156    156       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   METAL       191    191       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   METAL       194    194       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
SQ   SEQUENCE   223 AA;  25398 MW;  F74B4D892475FF26 CRC64;
     MAKAHAFSKK VGWIELITGP MFAGKTAELI RRLHRLEYAD VKYLVFKPRI DTRSTQNIKS
     RTGTSLPSIE VENAPEILSY IMSDNFDNEI KVIGIDEVQF FDDRICEVAN ILAENGFVVI
     ISGLDKNFKG EPFGPIAKLF AYADKITKLT AICNECGAEA THSLRKIDGK YANYDDEIVK
     IGCQEFYSAV CRHHHKVPNR PYLNANSEEF IRFFKNKKRN KNV
//
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