ID B5ZRT9_RHILW Unreviewed; 582 AA.
AC B5ZRT9;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=Cyclic nucleotide-binding protein {ECO:0000313|EMBL:ACI56816.1};
DE Flags: Precursor;
GN OrderedLocusNames=Rleg2_3549 {ECO:0000313|EMBL:ACI56816.1};
OS Rhizobium leguminosarum bv. trifolii (strain WSM2304).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX NCBI_TaxID=395492 {ECO:0000313|EMBL:ACI56816.1, ECO:0000313|Proteomes:UP000008330};
RN [1] {ECO:0000313|EMBL:ACI56816.1, ECO:0000313|Proteomes:UP000008330}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSM2304 {ECO:0000313|EMBL:ACI56816.1,
RC ECO:0000313|Proteomes:UP000008330};
RX PubMed=21304679; DOI=10.4056/sigs.44642;
RA Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K., Tiwari R.,
RA Malfatti S., Kiss H., Lapidus A., Copeland A., Nolan M., Land M.,
RA Ivanova N., Mavromatis K., Markowitz V., Kyrpides N., Melino V., Denton M.,
RA Yates R., Howieson J.;
RT "Complete genome sequence of Rhizobium leguminosarum bv trifolii strain
RT WSM2304, an effective microsymbiont of the South American clover Trifolium
RT polymorphum.";
RL Stand. Genomic Sci. 2:66-76(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
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DR EMBL; CP001191; ACI56816.1; -; Genomic_DNA.
DR RefSeq; WP_012559112.1; NC_011369.1.
DR AlphaFoldDB; B5ZRT9; -.
DR STRING; 395492.Rleg2_3549; -.
DR KEGG; rlt:Rleg2_3549; -.
DR eggNOG; COG0664; Bacteria.
DR eggNOG; COG4651; Bacteria.
DR HOGENOM; CLU_005126_1_1_5; -.
DR Proteomes; UP000008330; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR42751:SF1; CATION_PROTON ANTIPORTER YBAL-RELATED; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 33..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 451..565
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
SQ SEQUENCE 582 AA; 62098 MW; 4DFB8217F0CE5B8F CRC64;
MHQEVGLIAT VAVSFVFAAI LGYGADRLRL PPLVGYLLAG ILMGPFTPGF VADTALAGQL
AEMGVILLMF GVGLHFSASD LLAVRGIAVP GAIGRIILAT LLGIGLCKLW GWSLGAGIVL
GLSLSVASTV VLLKALEERN LVNAPSGRVA VGWLIVEDLV MVLALVLLPA LAELLGGNAA
ATNNHGLGEL SLALTIGLTL LKVAGFAAMA IFLGPRIVPW LLTMIARTGS RELFTLTVLA
IALGIAFGSA AIFGVSFALG AFFAGVVMSE SQLSHRAAAD SLPLQNAFSV LFFVSVGMLF
DPSILVSQPL AVIGALALVI LGKAIITFLI VILLRYPIGL GLTLAGGLAQ IGEFSFILAG
LGVSLGLLPH EGQDLILAAA ILSITLNPIV ILATDGLKKF VHSRWPSLWE SYGRTRQKTL
SKELEKIRAL GEEREREHQL KMQQLIETFP LFSEVNEDAQ EELLLLFKAK SAPPGERVIR
RGDRGDGMYF ISSGAVEVRL ASGAIRLEPG AFFGEMALLT GGRRTADVIA VDFCQFEVLE
RRDFNMFMSR HPNLRAAVSE MAQKRTEMND LRQQWEKSMD LS
//
