ID B6AB99_CRYMR Unreviewed; 447 AA.
AC B6AB99;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=glycine hydroxymethyltransferase {ECO:0000256|ARBA:ARBA00012256};
DE EC=2.1.2.1 {ECO:0000256|ARBA:ARBA00012256};
GN ORFNames=CMU_026590 {ECO:0000313|EMBL:EEA05651.1};
OS Cryptosporidium muris (strain RN66).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=441375 {ECO:0000313|Proteomes:UP000001460};
RN [1] {ECO:0000313|EMBL:EEA05651.1, ECO:0000313|Proteomes:UP000001460}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RN66 {ECO:0000313|EMBL:EEA05651.1,
RC ECO:0000313|Proteomes:UP000001460};
RA Lorenzi H., Inman J., Miller J., Schobel S., Amedeo P., Caler E.V.,
RA da Silva J.;
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777}.
CC -!- SIMILARITY: Belongs to the SHMT family.
CC {ECO:0000256|ARBA:ARBA00006376}.
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DR EMBL; DS989727; EEA05651.1; -; Genomic_DNA.
DR RefSeq; XP_002140000.1; XM_002139964.1.
DR AlphaFoldDB; B6AB99; -.
DR STRING; 441375.B6AB99; -.
DR EnsemblProtists; EEA05651; EEA05651; CMU_026590.
DR GeneID; 6994858; -.
DR VEuPathDB; CryptoDB:CMU_026590; -.
DR eggNOG; KOG2467; Eukaryota.
DR OMA; QICAFAV; -.
DR OrthoDB; 196371at2759; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000001460; Unassembled WGS sequence.
DR GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019264; P:glycine biosynthetic process from serine; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR001085; Ser_HO-MeTrfase.
DR InterPro; IPR039429; SHMT-like_dom.
DR PANTHER; PTHR11680; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR11680:SF28; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR Pfam; PF00464; SHMT; 1.
DR PIRSF; PIRSF000412; SHMT; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:EEA05651.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001460};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EEA05651.1}.
FT DOMAIN 13..397
FT /note="Serine hydroxymethyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF00464"
SQ SEQUENCE 447 AA; 51655 MW; A41F988AFE26FFBC CRC64;
MTSTSLLNLS ELIKEEDPEV YKLIKEEEYF QIDLLNLHPA DNIMPKSCQE VLRSILTNKY
SEGYPGARYY GGTDIIDKIE MTCINRVKKL FRLENKESPF GNWNLNVQGY SGSTVKMAIC
MGSIELNDHI MTFFNREEYK TVIEKFYHVN YYSLNSSKEY FDMDDIITKF RIFKPKIIFI
PSHVLPKAIN FEEFKIICDE FKTLLVVDIS ETAIFYVYSL YGEDYSRYNP FRYADVIYSN
TQSSLGGPKG GILMVNSSRN PDLFNKINSA LFPGLQGGPH NHQICAFAVQ LQNMLVSDFS
TYSKKIIENA QVLAQTLLDN DIPLLFKGTD NHMVIIDCND KNNNIPYVIL HRSLNWCGIN
HSTIYLNESD AYIRFGTYVF TARGGDCETM RTISNLIARC IKECQNLIVD VEYEQDIMKK
IIDNYNLRQI KDKICAIMKN LEFPDQI
//
