ID   B6ABQ1_CRYMR            Unreviewed;       766 AA.
AC   B6ABQ1;
DT   25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT   25-NOV-2008, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   SubName: Full=Mechanosensitive ion channel family protein {ECO:0000313|EMBL:EEA05803.1};
GN   ORFNames=CMU_028130 {ECO:0000313|EMBL:EEA05803.1};
OS   Cryptosporidium muris (strain RN66).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX   NCBI_TaxID=441375 {ECO:0000313|Proteomes:UP000001460};
RN   [1] {ECO:0000313|EMBL:EEA05803.1, ECO:0000313|Proteomes:UP000001460}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RN66 {ECO:0000313|EMBL:EEA05803.1,
RC   ECO:0000313|Proteomes:UP000001460};
RA   Lorenzi H., Inman J., Miller J., Schobel S., Amedeo P., Caler E.V.,
RA   da Silva J.;
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; DS989727; EEA05803.1; -; Genomic_DNA.
DR   RefSeq; XP_002140152.1; XM_002140116.1.
DR   AlphaFoldDB; B6ABQ1; -.
DR   EnsemblProtists; EEA05803; EEA05803; CMU_028130.
DR   GeneID; 6994948; -.
DR   VEuPathDB; CryptoDB:CMU_028130; -.
DR   eggNOG; KOG4629; Eukaryota.
DR   OMA; CERDDES; -.
DR   OrthoDB; 208877at2759; -.
DR   Proteomes; UP000001460; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.10.287.1260; -; 1.
DR   Gene3D; 2.30.30.60; -; 1.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   InterPro; IPR016688; MscS-like_plants/fungi.
DR   InterPro; IPR023408; MscS_beta-dom_sf.
DR   InterPro; IPR006685; MscS_channel_2nd.
DR   PANTHER; PTHR31618:SF7; MECHANOSENSITIVE ION CHANNEL PROTEIN; 1.
DR   PANTHER; PTHR31618; MECHANOSENSITIVE ION CHANNEL PROTEIN 5; 1.
DR   Pfam; PF00924; MS_channel_2nd; 1.
DR   SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001460};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        105..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        201..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        532..561
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        567..585
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          572..639
FT                   /note="Mechanosensitive ion channel MscS"
FT                   /evidence="ECO:0000259|Pfam:PF00924"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          441..460
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   766 AA;  87402 MW;  67CA7EE413A9B253 CRC64;
     MNRSSINRVL QSPDVGGAEA QSGRGSEAFF RTPSVVGQDI KKEEEEEEEE EDPRSIWLRL
     FLPDLSPLGG LLVIGIALCI VATYLKGTGV ERPFSYPLLV FFTDLFIYIC IMCTRYLITI
     YSLTQFGEGR FFAAVSGSLD PELVYCLWSG LCLILWMSEI RISNNDRNSI LSTSTLYSSR
     FFENISSALR IPKVPWDVIQ VAHIILVIMT VRRLLLSIIT FYFRLDFIMT INPQVVEFLR
     LYSLLRRIDT KWCLIKPHIQ KQEFQISSTE IEGINSFKNG IFLQNKDINT IIGTINVPSV
     PSMLIDSNIE HTAKSSSENW LALQFIKQYN VALFIDNMRY ELKTKQQARD CARYLFHDIL
     QNVHAIMLYH YIGRMDHVNP ISSLPPKSDS YSILGEDTFC HALIDFEDRH DIKSDINGKI
     GSNSDLPDKV LENKQISETD NLLDKNNQTS SNKNSQRIGS APTALPNSIL DILYDKPLGD
     LIKQIDTARR GQVTEEEWIR FFVGIYDTRK KILRAATSQE GIVQVFRRMV SIFLWFFTGI
     IILLMLGIDV NTLVISGAAI ISSLSVGLSY IYSNFFSAVI FVIFLNPYNV GDRIRVNNGG
     AMIVKKIETF YTEFHTTHES PVLIPHSWLS SQMIYNESRS KRCSSDIQFK ISDTTSPFSI
     EALGRAIQDY VTVRPSEFVA SNFWCGITEI QPGHYATVFI WITNTDPFHN RRKLMISKSK
     LLLFILHTLR QLGIQYTLPI TRVRLEQSHG TNMPTLWKDS IITKSG
//