ID B6ADR3_CRYMR Unreviewed; 191 AA.
AC B6ADR3;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=CLAC channel {ECO:0008006|Google:ProtNLM};
GN ORFNames=CMU_008450 {ECO:0000313|EMBL:EEA06354.1};
OS Cryptosporidium muris (strain RN66).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=441375 {ECO:0000313|Proteomes:UP000001460};
RN [1] {ECO:0000313|EMBL:EEA06354.1, ECO:0000313|Proteomes:UP000001460}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RN66 {ECO:0000313|EMBL:EEA06354.1,
RC ECO:0000313|Proteomes:UP000001460};
RA Lorenzi H., Inman J., Miller J., Schobel S., Amedeo P., Caler E.V.,
RA da Silva J.;
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMCO1 family.
CC {ECO:0000256|ARBA:ARBA00006537}.
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DR EMBL; DS989729; EEA06354.1; -; Genomic_DNA.
DR RefSeq; XP_002140703.1; XM_002140667.1.
DR AlphaFoldDB; B6ADR3; -.
DR STRING; 441375.B6ADR3; -.
DR EnsemblProtists; EEA06354; EEA06354; CMU_008450.
DR GeneID; 6995694; -.
DR VEuPathDB; CryptoDB:CMU_008450; -.
DR eggNOG; KOG3312; Eukaryota.
DR OrthoDB; 200265at2759; -.
DR Proteomes; UP000001460; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IEA:InterPro.
DR InterPro; IPR002809; EMC3/TMCO1.
DR InterPro; IPR008559; TMCO1.
DR PANTHER; PTHR20917:SF0; CALCIUM LOAD-ACTIVATED CALCIUM CHANNEL; 1.
DR PANTHER; PTHR20917; PNAS-RELATED; 1.
DR Pfam; PF01956; EMC3_TMCO1; 1.
DR SMART; SM01415; DUF106; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001460};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 110..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 191 AA; 21801 MW; 0C2A013720423014 CRC64;
MKDSNEFNKY LVLVVISMSL ILAIISELIS YFFVLRKSDY YKLRDNLTRT KLKLDKLKLK
EKSGIIIENT TMSSNFSIPR TKRDPKIEAL EQSITTINQK MSMIKLRSSF FTGLLFALLI
PFRTYLLGDV PVCKLPFEPV PMFRIITQAG LNNCAPNEAG SIFIFGQAFM AFRIIIQKAI
FMDATSSFGK I
//
