ID B6AZ77_9RHOB Unreviewed; 721 AA.
AC B6AZ77;
DT 25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=GTP pyrophosphokinase rsh {ECO:0000256|ARBA:ARBA00014315};
DE AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
GN Name=spoT/relA {ECO:0000313|EMBL:EDZ40968.1};
GN ORFNames=RB2083_482 {ECO:0000313|EMBL:EDZ40968.1};
OS Rhodobacteraceae bacterium HTCC2083.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae.
OX NCBI_TaxID=314270 {ECO:0000313|EMBL:EDZ40968.1, ECO:0000313|Proteomes:UP000005746};
RN [1] {ECO:0000313|Proteomes:UP000005746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTCC2083 {ECO:0000313|Proteomes:UP000005746};
RX PubMed=21036993; DOI=10.1128/JB.01268-10;
RA Kang I., Vergin K.L., Oh H.M., Choi A., Giovannoni S.J., Cho J.C.;
RT "Genome sequence of strain HTCC2083, a novel member of the marine clade
RT Roseobacter.";
RL J. Bacteriol. 193:319-320(2011).
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
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DR EMBL; DS995276; EDZ40968.1; -; Genomic_DNA.
DR AlphaFoldDB; B6AZ77; -.
DR STRING; 314270.RB2083_482; -.
DR eggNOG; COG0317; Bacteria.
DR HOGENOM; CLU_012300_3_0_5; -.
DR Proteomes; UP000005746; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 2.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:EDZ40968.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005746}.
FT DOMAIN 44..143
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 381..446
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 626..700
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 721 AA; 80945 MW; F59E6047098D6162 CRC64;
MSPDALLATV RTYNPKTNEA LIRTAFEYGE RMHEGQKRHS GEPYFTHPIA VAGILAEQKL
DDATLITALL HDTIEDTKST YGEVAQMFDE DIAKLVDGVT KLTNLQLSSS ETKQAENFRK
LFVAMAKDVR VILVKLADRL HNMRTIKAMR PEKQVIKARE TMDIYAPLAG RMGMQWMREE
LEDLAFRVLN PEGRASIIRR FIRLQRETGD VIEKITGDME KELAAHYIDA TIVGRAKKPY
SIWRKMEEKE QGFSRLSDIY GFRVITASDE DCYRVLGVIH RRWFAVPGRF KDYISQPKTN
GYRSIHTTVS GRDGKRVEVQ IRTRQMHDVA EAGVAAHWSY RDGIRSQNPF AVDPVKWVAS
LNEQFGPEDD HEDFLEAVKL EMYSDQVFCF TPKGEVVKLP RGATPLDFAY AIHTRIGSAC
VGAKVDGLRV PLWTRLKNGQ SVEIVTAQGQ QPQFTWLDIA ATGKAKSAIR RSLREQDRQR
FIKLGSELAR SAFENVGRKA TDKALQAAAK TLRLDDSDAM LAELGASLIT ANEVVRAVYP
ELVEKTDDSI DSNRAVIGLD QDQAHERAQC CQPLPGERII GITQRGRGVV VHAIDCAALS
QFEDQTHRWV DLHWQAGTHP PIHSAHLDVT IGNDAGVMGR ICTLIGEQGA NISDLAFTDR
KPDFYRLHLI VDLRDVEHLH SIISVLSAED DVAEVSRHQN PNDANISVTE IGTRLGLQAP
R
//
