ID   B6EGF6_ALISL            Unreviewed;       366 AA.
AC   B6EGF6;
DT   25-NOV-2008, integrated into UniProtKB/TrEMBL.
DT   25-NOV-2008, sequence version 1.
DT   27-MAR-2024, entry version 69.
DE   RecName: Full=Membrane-bound lytic murein transglycosylase A {ECO:0000256|PIRNR:PIRNR019422};
DE            EC=4.2.2.n1 {ECO:0000256|PIRNR:PIRNR019422};
DE   AltName: Full=Murein hydrolase A {ECO:0000256|PIRNR:PIRNR019422};
GN   Name=mltA {ECO:0000313|EMBL:CAQ78372.1};
GN   OrderedLocusNames=VSAL_I0687 {ECO:0000313|EMBL:CAQ78372.1};
OS   Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain
OS   LFI1238)).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Aliivibrio.
OX   NCBI_TaxID=316275 {ECO:0000313|EMBL:CAQ78372.1, ECO:0000313|Proteomes:UP000001730};
RN   [1] {ECO:0000313|EMBL:CAQ78372.1, ECO:0000313|Proteomes:UP000001730}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LFI1238 {ECO:0000313|EMBL:CAQ78372.1,
RC   ECO:0000313|Proteomes:UP000001730};
RX   PubMed=19099551; DOI=10.1186/1471-2164-9-616;
RA   Hjerde E., Lorentzen M.S., Holden M.T., Seeger K., Paulsen S., Bason N.,
RA   Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S.,
RA   Thurston S., Parkhill J., Willassen N.P., Thomson N.R.;
RT   "The genome sequence of the fish pathogen Aliivibrio salmonicida strain
RT   LFI1238 shows extensive evidence of gene decay.";
RL   BMC Genomics 9:616-616(2008).
CC   -!- FUNCTION: Murein-degrading enzyme. May play a role in recycling of
CC       muropeptides during cell elongation and/or cell division.
CC       {ECO:0000256|PIRNR:PIRNR019422}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exolytic cleavage of the (1->4)-beta-glycosidic linkage
CC         between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine
CC         (GlcNAc) residues in peptidoglycan, from either the reducing or the
CC         non-reducing ends of the peptidoglycan chains, with concomitant
CC         formation of a 1,6-anhydrobond in the MurNAc residue.; EC=4.2.2.n1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001420,
CC         ECO:0000256|PIRNR:PIRNR019422};
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DR   EMBL; FM178379; CAQ78372.1; -; Genomic_DNA.
DR   RefSeq; WP_012549492.1; NC_011312.1.
DR   AlphaFoldDB; B6EGF6; -.
DR   CAZy; GH102; Glycoside Hydrolase Family 102.
DR   KEGG; vsa:VSAL_I0687; -.
DR   eggNOG; COG2821; Bacteria.
DR   HOGENOM; CLU_037751_2_0_6; -.
DR   Proteomes; UP000001730; Chromosome 1.
DR   GO; GO:0019867; C:outer membrane; IEA:InterPro.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0009254; P:peptidoglycan turnover; IEA:UniProtKB-UniRule.
DR   CDD; cd22785; DPBB_MltA-like; 1.
DR   CDD; cd14668; mlta_B; 1.
DR   Gene3D; 2.40.240.50; Barwin-like endoglucanases; 1.
DR   Gene3D; 2.40.40.10; RlpA-like domain; 1.
DR   InterPro; IPR010611; 3D_dom.
DR   InterPro; IPR026044; MltA.
DR   InterPro; IPR005300; MltA_B.
DR   InterPro; IPR036908; RlpA-like_sf.
DR   PANTHER; PTHR30124; MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE A; 1.
DR   PANTHER; PTHR30124:SF0; MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE A; 1.
DR   Pfam; PF06725; 3D; 1.
DR   Pfam; PF03562; MltA; 1.
DR   PIRSF; PIRSF019422; MltA; 2.
DR   SMART; SM00925; MltA; 1.
DR   SUPFAM; SSF50685; Barwin-like endoglucanases; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Cell wall biogenesis/degradation {ECO:0000256|ARBA:ARBA00023316,
KW   ECO:0000256|PIRNR:PIRNR019422}; Glycosidase {ECO:0000313|EMBL:CAQ78372.1};
KW   Hydrolase {ECO:0000313|EMBL:CAQ78372.1};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR019422}.
FT   DOMAIN          120..253
FT                   /note="Lytic transglycosylase MltA"
FT                   /evidence="ECO:0000259|SMART:SM00925"
SQ   SEQUENCE   366 AA;  40576 MW;  C32E76105B47B08C CRC64;
     MLRKLPFVCI LLALAGCADQ PTDRAQQYLD GSFSSNLNEV SDIDSDKPSD FSAFKNQSKE
     VVERSESMSL RYEELYTKLQ QWIDESSNPA KLSNYGIQFA QMGGGDKQGN VMFTGYFSPV
     IEMRHKPTDK FKYPVYDKPA CGSNCPTRAE INAGALSGLG LELGYSDNMI DPFIMEVQGS
     GFIHFGDDDK LEYFAYGGKN NHPYVSIGKV LIERGEVERK DMSLKAIKEW VERNDDATVR
     ELLETNPSYV FFSPRDANHV LGTAGIPLIA GAAVAADRTL LPMGTPILAE VPQLDKDGKW
     TGKHVLKVLL ALDTGGAVKE NHLDQYYGMG PEAGIAAGHF KHFGRVWKLG LKDSETENPW
     EMPKKK
//