ID B6GYA5_PENRW Unreviewed; 1046 AA.
AC B6GYA5;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 24-JAN-2024, entry version 80.
DE SubName: Full=Pc12g08580 protein {ECO:0000313|EMBL:CAP80485.1};
GN ORFNames=Pc12g08580 {ECO:0000313|EMBL:CAP80485.1}, PCH_Pc12g08580
GN {ECO:0000313|EMBL:CAP80485.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP80485.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP80485.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NADPH + 2 oxidized [cytochrome P450] = H(+) + NADP(+) + 2
CC reduced [cytochrome P450]; Xref=Rhea:RHEA:24040, Rhea:RHEA-
CC COMP:14627, Rhea:RHEA-COMP:14628, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:55376, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:60344; EC=1.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00036596};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; AM920427; CAP80485.1; -; Genomic_DNA.
DR RefSeq; XP_002557688.1; XM_002557642.1.
DR AlphaFoldDB; B6GYA5; -.
DR STRING; 500485.B6GYA5; -.
DR GeneID; 8309117; -.
DR KEGG; pcs:Pc12g08580; -.
DR VEuPathDB; FungiDB:PCH_Pc12g08580; -.
DR eggNOG; KOG1158; Eukaryota.
DR HOGENOM; CLU_003662_1_0_1; -.
DR OMA; MIVAVNW; -.
DR OrthoDB; 5488444at2759; -.
DR BioCyc; PCHR:PC12G08580-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c12.
DR GO; GO:0016903; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors; IEA:InterPro.
DR CDD; cd06207; CyPoR_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 3.40.920.10; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR PANTHER; PTHR19384:SF109; SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR Pfam; PF01558; POR; 1.
DR PRINTS; PR00371; FPNCR.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF53323; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT DOMAIN 659..897
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 1046 AA; 114642 MW; 192C4595A43813C6 CRC64;
MGSSVPALSA LNGPTYVTAQ TLIQQVAYLL SDKIFSYSPE TFDLDAALKE WTSKGETNSN
GESPSVKALE TRQGAGNMAL GYLFSQDFDL KKRHIPQGIV ASSATLPYMR AALEQLSLLY
SVASPVAAHV AAVDYAGEDG LVSDYASTLS LAEDLGLGLV SSGSAHESQH MALFTTLLSS
VLPSIHIYDG VRVGRDTTRV IDVLDKDGLT RTYETIRKTL DETRNRHLDA QGKVLELLKT
LNGELGTDYS AFEYHGHSEP TSVLIAFGTV EATLTAQIAR SLAKDGVRVG VVNVRVYRPF
IEEEFLRVLP QSTKTVAVLG QVASEQAVQE EGVHSALYED VLASLTFATG REHNPACVEI
KYPRSQRWDL ISAAAAFQRV YDQPILTVNG ETNASLQLLD PASVQEYTFW DVDSSVTEAA
AQTLSQALGA DSASNVTLSK THDNLVQGGT IRVDIRKSAK IVDAPYAVTG ADVSYVGNIS
LLNDVDVLAS VKDNAKVIVN APGIKDEDLE KKLPATFKQA VAQRGISVFV VDSSAVEDSS
LDALVLQASF VRVALPAQEA LAAKKLSSVT GNAEALDNVT KDLEKLLRQI EVPESWKEPE
GVSEAVQLPK DIIANSFVSF DKNESEPPTL LKDWETAARG LAFKEAYGTR AALRPDLAHK
TFTVHVKENR RLTPTTYDRN IFHIEFDLGE TGLKYDIGEA LGIHAENDPE DVKNFIAFYG
LDPDAIVEVP SREDPAVLEN RTVYQALVQN VDIFGRPPKR FYEALAEFAS DEKEKTNLLT
LGGPDGATEF KRRAEVDTVT FADILLEYPS AHPEFHDIVR IIGPLKRREY SIASCQKVTP
TSVALMIVAV NWVDPNGRDR FGLATRYLSR LQPGSPITVS VKSSVMKLPP KSTQPLIMAG
LGTGLAPFRA FVQHRALEKA QGKEIGAVLL YMGSRHQREE YCYGEEWEAY QEAGVITLLG
AAFSRDQPEK IYIQDRMRQT LPEIIQAYIR EEGAFYLCGP TWPVPDVTAV LEEAIATEAK
NNGKKVETRK EIEKLKDEER YVLEVY
//