ID B6H220_PENRW Unreviewed; 475 AA.
AC B6H220;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 24-JAN-2024, entry version 65.
DE RecName: Full=Nickel/cobalt efflux system {ECO:0000256|RuleBase:RU362101};
GN ORFNames=Pc13g03730 {ECO:0000313|EMBL:CAP91442.1}, PCH_Pc13g03730
GN {ECO:0000313|EMBL:CAP91442.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP91442.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP91442.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362101};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362101}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NiCoT transporter (TC 2.A.52) family.
CC {ECO:0000256|ARBA:ARBA00010892, ECO:0000256|RuleBase:RU362101}.
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DR EMBL; AM920428; CAP91442.1; -; Genomic_DNA.
DR RefSeq; XP_002558810.1; XM_002558764.1.
DR AlphaFoldDB; B6H220; -.
DR GeneID; 8313473; -.
DR KEGG; pcs:Pc13g03730; -.
DR VEuPathDB; FungiDB:PCH_Pc13g03730; -.
DR eggNOG; ENOG502RIYK; Eukaryota.
DR HOGENOM; CLU_036094_0_1_1; -.
DR OMA; NGWVLYK; -.
DR OrthoDB; 2725900at2759; -.
DR BioCyc; PCHR:PC13G03730-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c13.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015099; F:nickel cation transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR004688; Ni/Co_transpt.
DR InterPro; IPR011541; Ni/Co_transpt_high_affinity.
DR PANTHER; PTHR31611; HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1; 1.
DR PANTHER; PTHR31611:SF0; HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1; 1.
DR Pfam; PF03824; NicO; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362101};
KW Nickel {ECO:0000256|ARBA:ARBA00022596};
KW Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362101};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362101};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362101}.
FT TRANSMEM 45..71
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 154..177
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 226..248
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 254..273
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 327..354
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 374..397
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT REGION 296..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 51674 MW; FA822FE66A52EBA0 CRC64;
MSGFNELVDT DLRGLDSDRK WSLQPLLRSA ERSHSKMPGI RKIPLRAIGI IAFIALLNII
VWVAAAIVLS YHHSLVSTAA LAYSLGLRHA FDADHISAID LMTRRLLATG QKPVTVGTFF
SLGHSTIVII TSIVVAATAA AVSERFDSFS TVGGIIGTSV SAAFLILLGL MNAYILYKLV
KQMEKVFNLP EGHEDEAWKI EGGGILFSVL KKMFKLIDRS WKMYPLGILF GLGFDTSSEI
ALLGISSIEA AKGTSFWVIL ILPALFTAGM CLLDTIDGAL MFSLYIQPAA NFLPQKPTSD
VSDTSSTATD PDELPQSQDN HRDPVAFLYY SIVLTTLTVI VAIVIGIIQL LTLILNVTDA
KGKFWDGVQV AGDYYDAIGG GICGCFIVFG LLSVLVYKPW RRWMDQRHGK HVANDVERYT
DDDISRGDAP GYGAIVTETS RTQHEGTATE VTGKGPASRV AVKETGESRL EDHIM
//
