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Database: UniProt
Entry: B6H5M0_PENRW
LinkDB: B6H5M0_PENRW
Original site: B6H5M0_PENRW 
ID   B6H5M0_PENRW            Unreviewed;       538 AA.
AC   B6H5M0;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   24-JAN-2024, entry version 74.
DE   RecName: Full=Succinyl-CoA:3-ketoacid-coenzyme A transferase {ECO:0000256|PIRNR:PIRNR000858};
DE            EC=2.8.3.5 {ECO:0000256|PIRNR:PIRNR000858};
GN   ORFNames=Pc14g00590 {ECO:0000313|EMBL:CAP74200.1}, PCH_Pc14g00590
GN   {ECO:0000313|EMBL:CAP74200.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS   54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP74200.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP74200.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA   van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA   Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- FUNCTION: Key enzyme for ketone body catabolism. Transfers the CoA
CC       moiety from succinate to acetoacetate. Formation of the enzyme-CoA
CC       intermediate proceeds via an unstable anhydride species formed between
CC       the carboxylate groups of the enzyme and substrate.
CC       {ECO:0000256|PIRNR:PIRNR000858}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate;
CC         Xref=Rhea:RHEA:24564, ChEBI:CHEBI:30031, ChEBI:CHEBI:35973,
CC         ChEBI:CHEBI:57292, ChEBI:CHEBI:90726; EC=2.8.3.5;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000858};
CC   -!- PATHWAY: Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA
CC       from succinyl-CoA: step 1/1. {ECO:0000256|PIRNR:PIRNR000858}.
CC   -!- SIMILARITY: Belongs to the 3-oxoacid CoA-transferase family.
CC       {ECO:0000256|ARBA:ARBA00007154, ECO:0000256|PIRNR:PIRNR000858}.
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DR   EMBL; AM920429; CAP74200.1; -; Genomic_DNA.
DR   RefSeq; XP_002560053.1; XM_002560007.1.
DR   AlphaFoldDB; B6H5M0; -.
DR   STRING; 500485.B6H5M0; -.
DR   GeneID; 8310295; -.
DR   KEGG; pcs:Pc14g00590; -.
DR   VEuPathDB; FungiDB:PCH_Pc14g00590; -.
DR   eggNOG; KOG3822; Eukaryota.
DR   HOGENOM; CLU_019942_1_1_1; -.
DR   OMA; YMVPGKV; -.
DR   OrthoDB; 177109at2759; -.
DR   BioCyc; PCHR:PC14G00590-MONOMER; -.
DR   UniPathway; UPA00929; UER00894.
DR   Proteomes; UP000000724; Contig Pc00c14.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0008260; F:succinyl-CoA:3-oxo-acid CoA-transferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046952; P:ketone body catabolic process; IEA:InterPro.
DR   Gene3D; 3.40.1080.10; Glutaconate Coenzyme A-transferase; 2.
DR   InterPro; IPR012792; 3-oxoacid_CoA-transf_A.
DR   InterPro; IPR012791; 3-oxoacid_CoA-transf_B.
DR   InterPro; IPR014388; 3-oxoacid_CoA-transferase.
DR   InterPro; IPR004165; CoA_trans_fam_I.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   NCBIfam; TIGR02429; pcaI_scoA_fam; 1.
DR   NCBIfam; TIGR02428; pcaJ_scoB_fam; 1.
DR   PANTHER; PTHR13707; KETOACID-COENZYME A TRANSFERASE; 1.
DR   PANTHER; PTHR13707:SF23; SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE; 1.
DR   Pfam; PF01144; CoA_trans; 2.
DR   PIRSF; PIRSF000858; SCOT-t; 1.
DR   SMART; SM00882; CoA_trans; 2.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 2.
PE   3: Inferred from homology;
KW   Mitochondrion {ECO:0000256|PIRNR:PIRNR000858};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000858}.
FT   ACT_SITE        364
FT                   /note="5-glutamyl coenzyme A thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000858-1"
SQ   SEQUENCE   538 AA;  57274 MW;  12D7C3B108A21947 CRC64;
     MTALRISTTL SRKALTACRP RLFLGVRTSV RPWQPFSTST STRYSITTPL KSLAPKVERS
     GSKLYKDADA AVADIKSGST ILSSGFGLCG VAETLINAMH RRGADQLHSL TAVSNNAGAA
     GKGGLSTLSQ NGQINRLILS YLGNNKALEK KYLTGHIAIE LCPQGTLAER LRAGGAGIPA
     FFTPTGEGKI PVRMDESGKV LESGKPRETR EFNGKTYLME EALTGDVAIL RAWKADEAGN
     CVFRYTTKAF GPIMAKAATL TIVEAENIVP IGSIDPNDVD LPGIFVDRIV PATDDKHIEI
     RKLRSGETTV AGSGKDEARI QRELIGRRAA KELKPGFYVN LGVGIPTLAP SFLPKDVKVW
     IQSENGILGM GDYPTEQELD PDIINAGKET VTLVPGAATF DSSESFGMIR GGHVDVSILG
     ALQVSANGDL ANYMIPGKVF KGMGGAMDLI SNPEKTKIVV ATSHVAKDGS PKIVQKCSLP
     LTGANVVSTI ITDLCVFQVD RATGELTLTE LAPGVEVEEV QSKTDAKFTI ADTLEIME
//
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