ID B6H717_PENRW Unreviewed; 698 AA.
AC B6H717;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Pc16g01150 protein {ECO:0000313|EMBL:CAP92785.1};
GN ORFNames=Pc16g01150 {ECO:0000313|EMBL:CAP92785.1}, PCH_Pc16g01150
GN {ECO:0000313|EMBL:CAP92785.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP92785.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP92785.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
CC -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC phagocytosis of apoptotic cells and cell motility. Acts in association
CC with DOCK1 and CRK. Was initially proposed to be required in complex
CC with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC nucleotide exchange factor (GEF) activity of DOCK1.
CC {ECO:0000256|ARBA:ARBA00024863}.
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DR EMBL; AM920431; CAP92785.1; -; Genomic_DNA.
DR RefSeq; XP_002560533.1; XM_002560487.1.
DR AlphaFoldDB; B6H717; -.
DR STRING; 500485.B6H717; -.
DR GeneID; 8315382; -.
DR KEGG; pcs:Pc16g01150; -.
DR VEuPathDB; FungiDB:PCH_Pc16g01150; -.
DR eggNOG; KOG2999; Eukaryota.
DR HOGENOM; CLU_009191_0_0_1; -.
DR OMA; WESHARP; -.
DR OrthoDB; 1473500at2759; -.
DR BioCyc; PCHR:PC16G01150-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c16.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024574; ELMO_ARM.
DR InterPro; IPR006816; ELMO_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12771:SF56; CED-12; 1.
DR PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR Pfam; PF11841; ELMO_ARM; 1.
DR Pfam; PF04727; ELMO_CED12; 1.
DR Pfam; PF16457; PH_12; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51335; ELMO; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT DOMAIN 240..421
FT /note="ELMO"
FT /evidence="ECO:0000259|PROSITE:PS51335"
FT REGION 243..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 698 AA; 78793 MW; 3579BED4E3ABDED7 CRC64;
METVNVAELV ERLGSDEDAV RKMAVFKLQG NIGDPSFADI FIAEGGLVRL RYLTLHASGN
TLAYSLASFS RLLDVDKGWE CVDQELVERI VELIVTHPLV NILRGAMSIL VSIVSHPYTG
NRTSQVNNFG FRALKPAIAI YPQFLEMLVS RLSSADHALC ANALQLINSL MRDSITHDPE
AEWPKFIQKL QDLGVIRAVY VLMQDSALQD LAHPLLEFQS LTKVLLRKWR DIPVNQEKPE
HRRALKGIYL ASNPEKNSDE ATENGDSARP SRRHHPEKWR RLGFETESPA GEFYEVGFLG
MMDLADYVRS HGDEFQNMLL EHSTKPSRQR CPIARASLAV TSILYEHFEV EKSDMDDTKT
YLISESRTGF DKLFQPLLLH WTRLHVAGLQ AFFRLWKATA AEEEDLDKLI ELVRILIGSV
VGGAARIKDV QDVEEELADF EYHRLRGLQM ELLELTYEDA WGQHLRQVRE ELHHEALQFV
KEQRIRSLLQ GSWFALDSHP KSESGPVQKS TATYQYAQLS HNRRYLHFGQ FDLMGDRPPE
LDTLPEKIDL SIVSSVVSNV STNPDHSSTA TVKTAPRQPT TKITIHGYVP STATGHGKGH
SHARSGSRTT QKEVVLLTLR PSSHIIASEW LDGLLMLLNQ QPITAETSKL IDLVSDYGLK
IRLLNVRFDD ATFAGEAPQV PARDGLDEDY YYDVFGGV
//
