ID B6HEK2_PENRW Unreviewed; 788 AA.
AC B6HEK2;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Pc20g07700 protein {ECO:0000313|EMBL:CAP86099.1};
GN ORFNames=Pc20g07700 {ECO:0000313|EMBL:CAP86099.1}, PCH_Pc20g07700
GN {ECO:0000313|EMBL:CAP86099.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP86099.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP86099.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AM920435; CAP86099.1; -; Genomic_DNA.
DR RefSeq; XP_002563293.1; XM_002563247.1.
DR AlphaFoldDB; B6HEK2; -.
DR STRING; 500485.B6HEK2; -.
DR GeneID; 8313361; -.
DR KEGG; pcs:Pc20g07700; -.
DR VEuPathDB; FungiDB:PCH_Pc20g07700; -.
DR eggNOG; KOG1083; Eukaryota.
DR HOGENOM; CLU_004379_3_0_1; -.
DR OMA; NCQNRYM; -.
DR OrthoDB; 950362at2759; -.
DR BioCyc; PCHR:PC20G07700-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c20.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR22884:SF512; N-METHYLTRANSFERASE (ASH1), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G06480)-RELATED; 1.
DR PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 384..430
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 441..557
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 565..581
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 1..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..604
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..634
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..759
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 86467 MW; 19B0E70A567FD0AC CRC64;
MAPRTSRSVA SAAPDAQAHE PTDDNMSLDV PEQLLTPENS RSETSSNNEN ALADEKPAGR
RRSTRVARAS LRPGEPLDDT NKEPAASSSE AYVDSLAKAK RSHSSLRHSI AVMESSLWSG
APVDDDTVAD DTAAPDTPVS KSSQDLQSED MNTALQQRTL RKRVGKALVE DEGTPTAGVV
PTRTSPRKSL RRSGRFSLMD KASDLVDRAS SILGKRTRGL ADKDLGRRAS LRPRNNAPSK
DETALSAVNE PASKKRRVSE SDLSKLQDQD TPEPEEPAVS ASRPRKIWLS HGLYTGQEPS
DSPPKQRRSK NSKKTGTGPM QRTILPMPMF KGARLLKTGR DYQLPYDIFS PLPPGQPKPN
EWRKTNKNVF VGDAGSFWKA NKKLELSTCM CTEDTGCDEN CQNRYMFYEC DNGNCRLGPE
CGNRNFEGLK QRTKAGGKYN IGVEVIKTAD RGYGVRSNRS FEPNQIIVEY TGEILTQLEC
EKRMRTVYKN NDCYYLMYFD QNMIIDATRG SIARFVNHAC EPNCRMEKWT VAGKPRMALF
AGDRGVSTGE ELSYDYNFDP YSNKNVQECR CGSANCRGFL GPRLKEKQQR AKELEKRKAE
GSPKTTTAKK VIGKKRKASE EAESDDEAPQ GKKRKIIRSK SIKAGVKKAV AAVRGKKTTK
TTAKGKTTTA VKSKTNVKLP TVKATGRIKA TVRASRSNKT AKETPASPKK TTSQLKRPSA
ETKKKILATA SKGSGASPRK PAKRVPAKSP VKAKKPAPKA KSTPKGGFGK GVKSAARRVM
KSVKGSKK
//
