ID B6HJP6_PENRW Unreviewed; 764 AA.
AC B6HJP6;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 24-JAN-2024, entry version 82.
DE SubName: Full=Pc21g06790 protein {ECO:0000313|EMBL:CAP95576.1};
GN ORFNames=Pc21g06790 {ECO:0000313|EMBL:CAP95576.1}, PCH_Pc21g06790
GN {ECO:0000313|EMBL:CAP95576.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP95576.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP95576.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; AM920436; CAP95576.1; -; Genomic_DNA.
DR RefSeq; XP_002567721.1; XM_002567675.1.
DR AlphaFoldDB; B6HJP6; -.
DR STRING; 500485.B6HJP6; -.
DR GeneID; 8314117; -.
DR KEGG; pcs:Pc21g06790; -.
DR VEuPathDB; FungiDB:PCH_Pc21g06790; -.
DR eggNOG; KOG1979; Eukaryota.
DR HOGENOM; CLU_004131_2_0_1; -.
DR OMA; ANYHVKK; -.
DR OrthoDB; 5475669at2759; -.
DR BioCyc; PCHR:PC21G06790-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c21.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03483; MutL_Trans_MLH1; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT DOMAIN 248..367
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 764 AA; 84121 MW; 9B30DD1C04A64CBC CRC64;
MEDNMHIDPI DQRGTKRAAE EDEPPEPPKP KKIKALDPDV VNKIAAGEII VAPMHALKEL
IENAVDAGST SVEVLIKEGG LKLLQITDNG HGIDRDDLPI LCERFTTSKL KEFEDLTSIG
TYGFRGEALA SISHIAHLTV TTKTAGSSCA WRAHYGDGKL IPAKPGQNAA PKATAGRGGT
QITVEDLFYN VPTRRRAFRS ASEEYAKILD VVGRYAVHCS GVAFSCRKHG DSGVSISTPV
SANTIDRIRQ IHGSAVANEL VEFKTEDMKF GFRASGLATN ANYHVKKTVI LLFINHRAVE
STAVKRAVEQ TYSAFLPKGG HPFVYLDLEI EPNRVDVNVH PTKREVNFLN EDEIIELVCT
EIRSKLAEVD SSRTFLTQSL LPGVQAIESI QRDQGAPVHE GTAEAIKAGA TPKTPATTKK
PYENNLIRTD SKVRKITAML GPAAASPRDP SNPEAPTETD TPTTSILDNG LQYETTDRQP
LKIALTSVKS LRASVRSEMH NTLTEMFASH TYVGLVDERR RLAAIQSGVK LYLIDYGLAC
HEFFYQVGLT DFGNFGVIRL DPAPKLVDLL KIAAESERQE HAESNGEEAD SIFANAPEMI
ARTLIDRREM LNEYFSMQIS PHGTLLTIPL LLKGYLPALA KLPRFLLRLG PYVDWGSEEG
CFRTFLRELA AFYTPEQLPV LSRTVVQDAL GESAMQGPVV ADGSEVEDDD EDAFVRARRA
QMVRMLEHAV FPALRARLVA TSRLLRGVVE VADLKGLYRV FERC
//
