ID B6HLY1_PENRW Unreviewed; 508 AA.
AC B6HLY1;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE RecName: Full=Solute carrier family 40 member {ECO:0000256|RuleBase:RU365065};
GN ORFNames=Pc21g08390 {ECO:0000313|EMBL:CAP95736.1}, PCH_Pc21g08390
GN {ECO:0000313|EMBL:CAP95736.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP95736.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP95736.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
CC -!- FUNCTION: May be involved in iron transport and iron homeostasis.
CC {ECO:0000256|RuleBase:RU365065}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU365065}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU365065}.
CC -!- SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A
CC subfamily. {ECO:0000256|ARBA:ARBA00006279,
CC ECO:0000256|RuleBase:RU365065}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU365065}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM920436; CAP95736.1; -; Genomic_DNA.
DR RefSeq; XP_002567878.1; XM_002567832.1.
DR AlphaFoldDB; B6HLY1; -.
DR GeneID; 8317232; -.
DR KEGG; pcs:Pc21g08390; -.
DR VEuPathDB; FungiDB:PCH_Pc21g08390; -.
DR eggNOG; KOG2601; Eukaryota.
DR HOGENOM; CLU_020370_5_0_1; -.
DR OMA; YPVFISY; -.
DR OrthoDB; 38357at2759; -.
DR BioCyc; PCHR:PC21G08390-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c21.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR009716; Ferroportin-1.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11660; SOLUTE CARRIER FAMILY 40 MEMBER; 1.
DR PANTHER; PTHR11660:SF57; SOLUTE CARRIER FAMILY 40 PROTEIN; 1.
DR Pfam; PF06963; FPN1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|RuleBase:RU365065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365065};
KW Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365065};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365065};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365065}.
FT TRANSMEM 65..88
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 294..319
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 362..381
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 454..476
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 508 AA; 55129 MW; B9CFC24E076D79F6 CRC64;
MEFESSPAPS RRSSENVNNS SSALLPTADN ASRPNDTPAP EARSVLTRLY ISHTLSTWNS
RMFEFGAVLF LASIFPGTLL YASIYALVRA FSAVALSSWL GAQVDHSDRL VAVRHSIVVW
QRVPVAVSCL CFIVTLSTDS WALTIGLFAV QGLLACMEKL AATANTVAVE RDWAIVISNS
INVPRQDLNA SMRRIDLFCK LLAPVFISLI DSISTRYAIW TVFTLNTASV LVEYMAIAQV
YQSVPALTKT QAPTTQADDI NNESDDAHHS ASPKVLHSLS ESLAPWKEYI ASPVFLASLA
LSLLYLTVLS FGATMVTYLL STGFTSLQVS YMRIGSVIAE LSGTWTAPMI MNRIGPIRSG
LWFLNWQFAC VAAAAVPFVA WDSSSRFVAG TLIAGVALSR VGLWGFDLSV QFLVQENIQE
HARARFSATE MALQNVFEML SFASTIAFPL PAQFVYPVMI SSGAVAVAAV CFAAYVRKER
GHLLHRSRCM GGDKASYQAI GSGSGLNV
//
