ID   B6HME7_PENRW            Unreviewed;       663 AA.
AC   B6HME7;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   24-JAN-2024, entry version 58.
DE   SubName: Full=Pc21g08890 protein {ECO:0000313|EMBL:CAP95786.1};
GN   ORFNames=Pc21g08890 {ECO:0000313|EMBL:CAP95786.1}, PCH_Pc21g08890
GN   {ECO:0000313|EMBL:CAP95786.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS   54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP95786.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP95786.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA   van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA   Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
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DR   EMBL; AM920436; CAP95786.1; -; Genomic_DNA.
DR   RefSeq; XP_002567928.1; XM_002567882.1.
DR   AlphaFoldDB; B6HME7; -.
DR   STRING; 500485.B6HME7; -.
DR   GeneID; 8317282; -.
DR   KEGG; pcs:Pc21g08890; -.
DR   VEuPathDB; FungiDB:PCH_Pc21g08890; -.
DR   eggNOG; KOG4269; Eukaryota.
DR   HOGENOM; CLU_017095_2_0_1; -.
DR   OMA; PYRSIDY; -.
DR   OrthoDB; 1359393at2759; -.
DR   BioCyc; PCHR:PC21G08890-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c21.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00159; RhoGAP; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR23176:SF125; GTPASE ACTIVATOR (BEM2), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04450)-RELATED; 1.
DR   PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT   DOMAIN          373..579
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          1..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          570..663
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..77
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        126..156
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..196
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        245..260
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        570..587
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   663 AA;  73069 MW;  0DFAE541326E7D3A CRC64;
     MSNRTSTVPN LDLSSCKTES KKDKVSSPVT PGDHSSDGPS PLTPRSPKSA SSSPLFKGAT
     IRPVTQDSDS KATSPILPLS PGTGPAEPTT PGITAIPQHF PSPKDSRHTR DASKSFFGNL
     KAPKSSHKPQ HSDSSENSTE HSKSRGSSRD RKTAMTSKQY ESTPDLPGAL ARANGSEKTN
     EPTGDNNPQQ TGTKKVGTDL EGAAPKKNKQ RFANLLTRSR SIRVEDSSGT KAPRRRPSTG
     LAKLEEFNQG ATTTAIPPRS ATAQPERAAQ KGLQPPERPA DSTSLRKERS HGNIVASGSL
     SQVSGASATI FSNLKSSSSG TADRIGKAGK GFFSKITRSG STNEREMITD DSYTCSVINL
     PLIEQARKTR IAKKLEDCRD KTEFWMPALP YRSIDYLNFK GCEEEGLYRV PGSGREVKHW
     QRRFDTELDI DLFEVPDLYD INTIGSLFKA WLRELPDELF PKSTQTMIAM KCEGATTAPQ
     LLKDELSKLP PYHYYLLFAI TCHLNLLHSY VDQNKMDYRN LCICFQPCMK IDAFCFQFLV
     CDWKNCWQGC WTEKEYLEIE KKMDERDLRV SQEQEAAMAK ERASASHERA VSSSSSSAGE
     EPRKPPREPV RPATSHLETT RAETARPATA RTRKAPPKNI ETAHSRSISQ LPELGPPLSP
     IKI
//