ID B6HT36_PENRW Unreviewed; 1173 AA.
AC B6HT36;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Pc22g08770 protein {ECO:0000313|EMBL:CAP98165.1};
GN ORFNames=Pc22g08770 {ECO:0000313|EMBL:CAP98165.1}, PCH_Pc22g08770
GN {ECO:0000313|EMBL:CAP98165.1};
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP98165.1, ECO:0000313|Proteomes:UP000000724};
RN [1] {ECO:0000313|EMBL:CAP98165.1, ECO:0000313|Proteomes:UP000000724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC {ECO:0000313|Proteomes:UP000000724};
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
CC -!- FUNCTION: RNA-binding nucleolar protein required for pre-rRNA
CC processing. Involved in production of 18S rRNA and assembly of small
CC ribosomal subunit. {ECO:0000256|ARBA:ARBA00024893}.
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DR EMBL; AM920437; CAP98165.1; -; Genomic_DNA.
DR RefSeq; XP_002564889.1; XM_002564843.1.
DR AlphaFoldDB; B6HT36; -.
DR STRING; 500485.B6HT36; -.
DR GeneID; 8305689; -.
DR KEGG; pcs:Pc22g08770; -.
DR VEuPathDB; FungiDB:PCH_Pc22g08770; -.
DR eggNOG; KOG4574; Eukaryota.
DR HOGENOM; CLU_005652_0_0_1; -.
DR OMA; MWEISQG; -.
DR OrthoDB; 169938at2759; -.
DR BioCyc; PCHR:PC22G08770-MONOMER; -.
DR Proteomes; UP000000724; Contig Pc00c22.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR033133; PUM-HD.
DR InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR47093; PROTEIN JSN1-RELATED; 1.
DR PANTHER; PTHR47093:SF1; PROTEIN JSN1-RELATED; 1.
DR Pfam; PF00806; PUF; 3.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00025; Pumilio; 6.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50302; PUM; 3.
DR PROSITE; PS50303; PUM_HD; 1.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 466..540
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 605..961
FT /note="PUM-HD"
FT /evidence="ECO:0000259|PROSITE:PS50303"
FT REPEAT 670..705
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REPEAT 706..742
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REPEAT 743..781
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 959..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1146..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..985
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1054
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1173 AA; 126791 MW; D482ACA246FF375B CRC64;
MLPVSRPDGQ MNFNYIPTTQ PMSGTSTGRS SPSDLAGSGN PRMPFGPSPG FASRGTQNCD
NRLTLLDSSR RAREIQAQEG ISPSIWGPPT SGHSTPLREN IPESPSQDSF PDLIPTTNGS
MDSPGRRARA GTVPSRFPPM GTLNEMDLQQ PYLSQTSRPT PSTSPFRPPG VSGIDTSSKV
ASSTGVPNPA SLSRLRAGSM PQRSNFLGGG GPFGPSLFST NWSTGRERAT TLTSIRSSEG
PTSPSHSSFS RDGLADTDVK TLDYLGLAET PQQGMSSLAR PSMEALMQQQ QQQQQASALP
PLLAELAMMK NNNRFRSYSV NAKEKYADDE DLEYENRYSQ LPSGTMTPTA AATAAQLAAT
QAQIHQHNLA VQAFASHASV SRPRARTAGI LEAPPQRSSI RNYLATPSRL DNSFSASDLQ
IAENGEYDEL SEAVQLMHLG GNGIPAMSGR PAGEMADENN QDGPTRALWI GSIPVSTTVT
SLEAIFGMYG KIESTRVLTH KNCGFVNFDR LDSAVQAKSL LNGKEIFPGA GPVRIGYAKV
PGASATGTPG ANGIQSSPTP EQNFRSNLAA ADGADRADSA NVIPQIPALA DLLPEMVQIV
QEFGASEDDL KNITASIQAS IAFKAFEDEI PSVPETSQSR MFDAPRLRDI RKRIDNGACS
IQEIEETAEA MLPEIAELAS DYLGNTVVQK LFEFCSESTK EQMLTHIAPH LSEIGVHKNG
TWAAQKIIDV AKTPSQMKLI VDALRPYTVP LFLDQYGNYV LQCCLRFGSP FNSFIFESML
SRVWEIAQGR FGARAMRACL ESHHATKDQQ RMLASAIALH SVQLATNANG ALLLTWFLDT
CTFPRRRTVL APRLVPHLVH LCTHKVAYLT VLKVINQRNE PDARDIVLKA LFFSPGDEVL
EKILSDQTSG ATLIFKVLTT PFFDESMRTE VVKNVSKVLT KLKASPSQGY KRLMDEVGLS
SRGSGREHHH GREHSTPEKP QHRQSSRHGS TGYPGQPSMD RQYNGQFAPN TFGQNPDNRP
ISADQTNAPP LDPYSTNGLG SHMNGLSGAG GYSQESLSQQ QLQYQAFLAA QARGVPTGYP
GMSGANYGYP AGSPAVDNLR SLQPQQASTL PAGPGQMSPS PMLAQNNYQQ FSPVVNPAQM
YQYPPQYYPQ AQSVQGQPGG GRRGRVSSFS DRP
//
