ID   B6HVC3_PENRW            Unreviewed;       651 AA.
AC   B6HVC3;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   27-MAR-2024, entry version 69.
DE   RecName: Full=poly(A)-specific ribonuclease {ECO:0000256|ARBA:ARBA00012161};
DE            EC=3.1.13.4 {ECO:0000256|ARBA:ARBA00012161};
GN   ORFNames=Pc22g14870 {ECO:0000313|EMBL:CAP98775.1}, PCH_Pc22g14870
GN   {ECO:0000313|EMBL:CAP98775.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS   54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP98775.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP98775.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA   van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA   Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001663};
CC   -!- SIMILARITY: Belongs to the CAF1 family.
CC       {ECO:0000256|ARBA:ARBA00008372}.
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DR   EMBL; AM920437; CAP98775.1; -; Genomic_DNA.
DR   RefSeq; XP_002565407.1; XM_002565361.1.
DR   AlphaFoldDB; B6HVC3; -.
DR   STRING; 500485.B6HVC3; -.
DR   GeneID; 8308712; -.
DR   KEGG; pcs:Pc22g14870; -.
DR   VEuPathDB; FungiDB:PCH_Pc22g14870; -.
DR   eggNOG; KOG0304; Eukaryota.
DR   HOGENOM; CLU_027974_3_0_1; -.
DR   OMA; QMRDRIF; -.
DR   OrthoDB; 341493at2759; -.
DR   BioCyc; PCHR:PC22G14870-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c22.
DR   GO; GO:0030014; C:CCR4-NOT complex; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:UniProt.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR039637; CNOT7/CNOT8/Pop2.
DR   InterPro; IPR006941; RNase_CAF1.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR10797; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT; 1.
DR   PANTHER; PTHR10797:SF0; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 7; 1.
DR   Pfam; PF04857; CAF1; 2.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   REGION          23..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   651 AA;  70812 MW;  8B7596403914F46B CRC64;
     MPPPVGRYAP SGLNAPYNIQ QAHLQSQHPA HAQSGNTLPP PSLGHPGFAG NPNTNINPFT
     LSGGIANGMA VAGFPGAGAG DGGGTGLASH AAQMGFARGA QMQQQQLHQG HDGRLALEAK
     GGAVKSRIRD VWKHNLAHEM AVLRQLVDKY PYISMDTEFP GIVARPIGSF SNKADYHYQT
     LRCNVDLLKM IQLGITLFND EGEVPPASGT DANGQAYGVP APCTWQFNFR FSLEGDMYAQ
     ESTAMLAKSG IDFAMHEKNG IDPFEFGALL ISSGLVLLDD VHWVSFHSGY DFGYLMKIML
     CSQLPENEEE FHKLLTIFFP SLYDIKYLMK HAGRNQAVNG SPLSQAAAQI LTNLGQKSGL
     QDIADELGVK RVGIAHQAGS DSLVTGEIYW KTRQLIFGGA IDDSKYSGQI WGLNGQMPAV
     AYNMAQQTPN LNGATIYSGG TPSTPNTGSH GAGAHTPQHY GAGYNAPTPG AYQMGRTRES
     CSFPSIFGIV FTLMALRRLR CLCRVLASGR RCWAGGCLAF DMVGFESIYE AFTGSRILVS
     VRSIWPGFVN PRAPRLFRST PYHLMGSARR IYISSRMTRQ GPQLQTAIEL KHTFSIEHCH
     ATSLILPRDV TNDMNNTDYT NIKLQTSISL PFWGWRYHAN PNQVIGSGLR K
//