ID B6IY67_RHOCS Unreviewed; 1047 AA.
AC B6IY67;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN Name=acrB {ECO:0000313|EMBL:ACJ01241.1};
GN OrderedLocusNames=RC1_3898 {ECO:0000313|EMBL:ACJ01241.1};
OS Rhodospirillum centenum (strain ATCC 51521 / SW).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Rhodospirillaceae; Rhodospirillum.
OX NCBI_TaxID=414684 {ECO:0000313|EMBL:ACJ01241.1, ECO:0000313|Proteomes:UP000001591};
RN [1] {ECO:0000313|Proteomes:UP000001591}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51521 / SW {ECO:0000313|Proteomes:UP000001591};
RA Touchman J.W., Bauer C., Blankenship R.E.;
RT "Genome sequence of Rhodospirillum centenum.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACJ01241.1, ECO:0000313|Proteomes:UP000001591}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51521 / SW {ECO:0000313|Proteomes:UP000001591};
RX PubMed=20500872; DOI=10.1186/1471-2164-11-325;
RA Lu Y.K., Marden J., Han M., Swingley W.D., Mastrian S.D., Chowdhury S.R.,
RA Hao J., Helmy T., Kim S., Kurdoglu A.A., Matthies H.J., Rollo D.,
RA Stothard P., Blankenship R.E., Bauer C.E., Touchman J.W.;
RT "Metabolic flexibility revealed in the genome of the cyst-forming alpha-1
RT proteobacterium Rhodospirillum centenum.";
RL BMC Genomics 11:325-325(2010).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU364070}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942,
CC ECO:0000256|RuleBase:RU364070}.
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DR EMBL; CP000613; ACJ01241.1; -; Genomic_DNA.
DR RefSeq; WP_012569014.1; NC_011420.2.
DR AlphaFoldDB; B6IY67; -.
DR STRING; 414684.RC1_3898; -.
DR KEGG; rce:RC1_3898; -.
DR eggNOG; COG0841; Bacteria.
DR HOGENOM; CLU_002755_0_2_5; -.
DR OrthoDB; 9806532at2; -.
DR Proteomes; UP000001591; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF13; MULTIDRUG EFFLUX PUMP SUBUNIT ACRB-RELATED; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW Cell membrane {ECO:0000256|RuleBase:RU364070};
KW Membrane {ECO:0000256|RuleBase:RU364070};
KW Reference proteome {ECO:0000313|Proteomes:UP000001591};
KW Transmembrane {ECO:0000256|RuleBase:RU364070};
KW Transmembrane helix {ECO:0000256|RuleBase:RU364070};
KW Transport {ECO:0000256|RuleBase:RU364070}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 392..416
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 437..458
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 470..497
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 537..555
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 873..890
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 897..917
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 923..946
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 967..988
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 1000..1026
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
SQ SEQUENCE 1047 AA; 112068 MW; AE9A266049C11909 CRC64;
MAKFFIDRPI FAWVIAIVIM LAGALAIFRL PIEQYPTIAP PAVTITASYP GASASTLEDT
VTQVIEQKLT GIDYLRYFSS TSDSQGNVSI TLTFEPEADP DIAQVQVQNK LQLAIPQLPQ
EVQQRGLTVT KSARDFLMVV GFVSADGSMT EGEISDYVAS TIQDPMSRVP GVGTVIVFGP
QNAMRIWLDP ERMNSYGMTV TDVINAVEAE NAQISAGQLG GAPSVPGQQL NATIVAQTRM
RTADEFAGIL LRVNADGSQV RLSDVARVEL GQDSYEIKGR YNGNPASGLA IRLATGANAL
DTAEAVRARV ADLQPFFPPG LEVIYPLDTT PFIKLSIEGV VHTLLEAIAL VFLVMFVFLQ
NFRATLIPTI AVPVVLLGTF GILSAFGFTI NVLTMFAMVL AIGLLVDDAI VVVENVERVM
AEEKLPPREA TRKSMEQITG ALIGIALVLS AVFVPMAFFG GSAGVIYRQF SLTIVSAMGL
SVLVALILTP ALCATILKPH ADGGHAHTRG PFGWFNRGFD RSLRAYQGGV RGAVNRLGRY
GIAYVLILIG LGVLFSRMPT SFLPTEDRGQ LFVLWTAPPG ATLERTLETA KTVEKHFLET
EKEAVEGLFT VSGFSFAGRG QNAGMAFVRL RDWELRDAPA LKAEALAGRA MGALMRVKDA
MVFTIMPPSV PGLGNATGFD MQLVDRAGVG HDALMQARNQ LLGMAAQDPR LAGVRPNGLD
DSPQYRVDVD REKARALGLS IADINRTLQT AWGSSYVDDF IDNGRVKRVY VQADAPYRML
PGDIDNWYVR NASGQMVPFS AFATGHWTYG SPQLERYNGV PSVNIQGSAA PGISSGEAMA
AMEELVGRLP PGIGLEWTGL SYEERLTGAQ APALYALSTL VIFLCLAALY ESWSVPAAVM
LVVPLGVLGA VVAALGRGLP SDVYFQVGLL TTIGLASKNA ILIVEFAKSL YEQGMGLIEA
TIEAARLRLR PILMTSLAFI LGVLPLAIAK GAGAESQNAI GTGVMGGMIA ATVLAIYFVP
VFFVAVMKVT TRWRGAPAPQ QQPGPAE
//
