ID B6JX20_SCHJY Unreviewed; 360 AA.
AC B6JX20;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=choline-phosphate cytidylyltransferase {ECO:0000256|ARBA:ARBA00026101};
DE EC=2.7.7.15 {ECO:0000256|ARBA:ARBA00026101};
GN Name=pcy1 {ECO:0000313|JaponicusDB:SJAG_00946};
GN ORFNames=SJAG_00946 {ECO:0000313|EMBL:EEB05921.1};
OS Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB05921.1, ECO:0000313|Proteomes:UP000001744};
RN [1] {ECO:0000313|EMBL:EEB05921.1, ECO:0000313|Proteomes:UP000001744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- SIMILARITY: Belongs to the cytidylyltransferase family.
CC {ECO:0000256|ARBA:ARBA00010101}.
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DR EMBL; KE651166; EEB05921.1; -; Genomic_DNA.
DR RefSeq; XP_002172214.1; XM_002172178.2.
DR AlphaFoldDB; B6JX20; -.
DR STRING; 402676.B6JX20; -.
DR EnsemblFungi; EEB05921; EEB05921; SJAG_00946.
DR GeneID; 7050818; -.
DR JaponicusDB; SJAG_00946; pcy1.
DR VEuPathDB; FungiDB:SJAG_00946; -.
DR eggNOG; KOG2804; Eukaryota.
DR HOGENOM; CLU_034585_5_2_1; -.
DR OMA; MATTDYQ; -.
DR OrthoDB; 5474784at2759; -.
DR Proteomes; UP000001744; Unassembled WGS sequence.
DR GO; GO:0042564; C:NLS-dependent protein nuclear import complex; IEA:EnsemblFungi.
DR GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR GO; GO:0004105; F:choline-phosphate cytidylyltransferase activity; IBA:GO_Central.
DR GO; GO:0031210; F:phosphatidylcholine binding; IBA:GO_Central.
DR CDD; cd02174; CCT; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR041723; CCT.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR045049; Pcy1-like.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR PANTHER; PTHR10739:SF13; CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR10739; CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotidyltransferase {ECO:0000313|EMBL:EEB05921.1};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000001744};
KW Transferase {ECO:0000313|EMBL:EEB05921.1}.
FT DOMAIN 105..233
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
FT REGION 1..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..80
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 360 AA; 40612 MW; 9AF80A16C0282B22 CRC64;
MSSTQDTVEK KRSVLTPDSQ SLENVDSDPS KRPKTASPNE SPSHSDEDTH SIHTDVSTIS
GQMGEVELNK DEDDASKKSL QYADSPDAYP YHINDPPTDR PVRVYADGVF DLFHVGHMRQ
LEQAKKVFPN VHLIVGIPSD ELTHKLKGLT VLSDKERAEA LRHCKWVDEV VENAPWIITP
EFLDEHKIDF VAHDDIPYAS VDSGDIYAPV KNLGKFIPTK RTEGVSTSDI ITRIIRNYDQ
YVLRNLSRGI DRRELNVSLL KKNELDIRRH IKLLRDTLRS HWVSTTRDLR ADIKSFLSVA
TTDYQLQHTP LHESSAPPSP VGVRIMNGIN RWMQRRASSN NDLHSTSQSV ASSASEEAAH
//
