ID B6K055_SCHJY Unreviewed; 799 AA.
AC B6K055;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 2.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Fork head transcription factor Fhl1 {ECO:0000313|EMBL:EEB06205.2};
GN Name=fhl1 {ECO:0000313|JaponicusDB:SJAG_01243};
GN ORFNames=SJAG_01243 {ECO:0000313|EMBL:EEB06205.2};
OS Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB06205.2, ECO:0000313|Proteomes:UP000001744};
RN [1] {ECO:0000313|EMBL:EEB06205.2, ECO:0000313|Proteomes:UP000001744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR EMBL; KE651168; EEB06205.2; -; Genomic_DNA.
DR RefSeq; XP_002172498.2; XM_002172462.2.
DR AlphaFoldDB; B6K055; -.
DR STRING; 402676.B6K055; -.
DR EnsemblFungi; EEB06205; EEB06205; SJAG_01243.
DR GeneID; 7048394; -.
DR JaponicusDB; SJAG_01243; fhl1.
DR VEuPathDB; FungiDB:SJAG_01243; -.
DR eggNOG; KOG2294; Eukaryota.
DR HOGENOM; CLU_352014_0_0_1; -.
DR OMA; DICEWIS; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000001744; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd22701; FHA_FKH1-like; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45881; CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR45881:SF1; FORK HEAD PROTEIN HOMOLOG 2; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000001744};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 68..123
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 337..431
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 337..431
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 157..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 745..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 799 AA; 84529 MW; A591822FBDA8E0B5 CRC64;
MKEVFESKIE SIGGKTLGFV GKNLNSLEGM QKNEVQNEVP EKGSKKHVQA YAKLEFDNFS
FFVQSLQVTI GRKAKSSSHC DLYIDDTKAI SREHAKIFYN FSTRRFEFVI LGKNGAFVNG
EFFEKGRTVP LTNGARIQIG RVPFSFLLPQ APSKVSPVQR PATLSNGGVA GTTQNEKKEP
GLLRRLVVPP SKEHFNESNP LAQASTASGN LTPLSIAPEQ LRHKEPSSQN LPPVADAIKH
SEIATSTAPV SSIPSTASSS LSPSLSKTPL SANQNSITAV KLENTATTVA ASGASQTINT
PVQYSNGHPG PSQQIGVAAH NGANAALFQS QSTAITKPNL SYASLIARTL IANSNRKMTL
NDICEWISDH WLYYKLQPPT WHNSIRHNLS LNKAFIRVPR QQNEPGKGSF WMLDPACIPQ
FEGTNVRRTK RATTPASVSA PVAHRVSHTA AAAVKQEDEA HAASSLTSEK SSAAVGAATP
SARNSPVATT STASARVSAA AARRNLPYLR PDMQPIILRD GKFTLNPDFF KNANGESQKP
NPQALHAIAL LQQHITKQLG PAAVNNPQHA IAIANALAMT LAQQLQQQQQ RQQFEQQQQY
AASKRRRTSK SSASGAGTPE SSASPSLSSL FTAQVHAATA NSTAATSSAA AATVAHAQHY
HAHPSTDPLP PGPFSNRTHA AVPSSSVATS RLSPDAAATA TASSPTPVLT PYARVQQAAG
TGAAAPITGS VSSVPAAAPN ISASAVSPVT DSMPTSHEPS PNTHSTTPVS LPSYVSPNAA
RSAAPDTRPN AEPSPRQLR
//
