ID B6K089_SCHJY Unreviewed; 439 AA.
AC B6K089;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=AMSH protein {ECO:0000313|EMBL:EEB06239.2};
GN Name=sst2 {ECO:0000313|JaponicusDB:SJAG_01281};
GN ORFNames=SJAG_01281 {ECO:0000313|EMBL:EEB06239.2};
OS Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB06239.2, ECO:0000313|Proteomes:UP000001744};
RN [1] {ECO:0000313|EMBL:EEB06239.2, ECO:0000313|Proteomes:UP000001744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M67C family.
CC {ECO:0000256|ARBA:ARBA00010981}.
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DR EMBL; KE651168; EEB06239.2; -; Genomic_DNA.
DR RefSeq; XP_002172532.2; XM_002172496.2.
DR AlphaFoldDB; B6K089; -.
DR STRING; 402676.B6K089; -.
DR MEROPS; M67.A14; -.
DR EnsemblFungi; EEB06239; EEB06239; SJAG_01281.
DR GeneID; 7052356; -.
DR JaponicusDB; SJAG_01281; sst2.
DR VEuPathDB; FungiDB:SJAG_01281; -.
DR eggNOG; KOG2880; Eukaryota.
DR HOGENOM; CLU_023304_4_0_1; -.
DR OMA; RQNAFFI; -.
DR OrthoDB; 5490729at2759; -.
DR Proteomes; UP000001744; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0061578; F:K63-linked deubiquitinase activity; IBA:GO_Central.
DR GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; IEA:EnsemblFungi.
DR GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:EnsemblFungi.
DR GO; GO:0043130; F:ubiquitin binding; IEA:EnsemblFungi.
DR GO; GO:0008270; F:zinc ion binding; IEA:EnsemblFungi.
DR GO; GO:0120113; P:cytoplasm to vacuole transport by the NVT pathway; IEA:EnsemblFungi.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:EnsemblFungi.
DR CDD; cd08066; MPN_AMSH_like; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR044098; STAMBP/STALP-like_MPN.
DR InterPro; IPR015063; USP8_dimer.
DR PANTHER; PTHR12947; AMSH-LIKE PROTEASE; 1.
DR PANTHER; PTHR12947:SF13; FI19924P1; 1.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF08969; USP8_dimer; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR SUPFAM; SSF102712; JAB1/MPN domain; 1.
DR PROSITE; PS50249; MPN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001744};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 267..398
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
FT REGION 197..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..224
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 49694 MW; 8FFC76E789D4B633 CRC64;
MNVNSDEHVP LSPRALAERA SQFTFNRNIP LRNWLRTGTT LLKQACIYIR EKDFENGLFL
LYRYAELFFH CQTHPEASQY KKELHEFYDT VNTALEEITL LKPLVQESYD KQVELLKRQK
IEDENLNKFL VSKNHDVDKI PQQTNHSISR THSSWTVDDL KLYPASSTKS NDETHKAHSH
TLDFSYPSAT TTSSVQNSAA GIPISAPRPI PNVPTSQTNG PPPLPNKPLN KLTSQFLHFS
PPSEVPEKQT KSFKIQCYTE GGKPLRTVFL PSSIRSTFLR IAKPNTDRRL ETCGILCGKL
RQNAFFITKL VIPPQEATTD TCSTTDEAGL FEYQDKHDLL TLGWIHTHPT QTCFMSSVDL
HTHCSYQLML PEAIAIVLAP SKKLSSGIFR LLDPTGLQTV VQCRKPGLFH PHEGRIYTSA
EPPGHVRELD APLEVVDLR
//
