ID B6K0P3_SCHJY Unreviewed; 573 AA.
AC B6K0P3;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Elongation factor 1 alpha like protein {ECO:0000313|EMBL:EEB07514.2};
GN Name=hbs1 {ECO:0000313|JaponicusDB:SJAG_02601};
GN ORFNames=SJAG_02601 {ECO:0000313|EMBL:EEB07514.2};
OS Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB07514.2, ECO:0000313|Proteomes:UP000001744};
RN [1] {ECO:0000313|EMBL:EEB07514.2, ECO:0000313|Proteomes:UP000001744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
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DR EMBL; KE651166; EEB07514.2; -; Genomic_DNA.
DR RefSeq; XP_002173807.2; XM_002173771.2.
DR AlphaFoldDB; B6K0P3; -.
DR STRING; 402676.B6K0P3; -.
DR EnsemblFungi; EEB07514; EEB07514; SJAG_02601.
DR GeneID; 7047708; -.
DR JaponicusDB; SJAG_02601; hbs1.
DR VEuPathDB; FungiDB:SJAG_02601; -.
DR eggNOG; KOG0458; Eukaryota.
DR HOGENOM; CLU_007265_3_2_1; -.
DR OMA; CFETEHR; -.
DR OrthoDB; 5477300at2759; -.
DR Proteomes; UP000001744; Unassembled WGS sequence.
DR GO; GO:1990533; C:Dom34-Hbs1 complex; IEA:EnsemblFungi.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0003746; F:translation elongation factor activity; IBA:GO_Central.
DR GO; GO:0002181; P:cytoplasmic translation; IEA:UniProt.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:EnsemblFungi.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR GO; GO:0006414; P:translational elongation; IBA:GO_Central.
DR CDD; cd01883; EF1_alpha; 1.
DR CDD; cd16267; HBS1-like_II; 1.
DR CDD; cd04093; HBS1_C_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015033; HBS1-like_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR PANTHER; PTHR23115:SF288; ELONGATION FACTOR 1 ALPHA-LIKE PROTEIN; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF08938; HBS1_N; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Elongation factor {ECO:0000313|EMBL:EEB07514.2};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:EEB07514.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001744};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 158..384
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 117..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 12..39
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 117..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 573 AA; 63962 MW; 7D11AADB95E82CC4 CRC64;
MSRHKDLKNL DLNDYEDEFE AEEELTEDQE EAYREAIEQV QTALEGTNIP FQEIKDTVWY
YYFDVNKSVN YLLSKAIKAK EKDAKKTPVA QSQTKENSTK DVTAAVKKVT ISQPSNALRK
KQVIPQTTKT ESEHAQIPQK KEPKLLDIPS LYEKEHEKPS IHLVVSGHVD SGKSTMIGRL
LYEVGMVDER SMQKLKQSAA NAGKGSFSYA WLLDSTDEER ARGVTMDVAD TTFESSKHIY
QIGDAPGHKD FISGMIAGAY LSDYAILVVD ASPNNFERGF FSNGQTREHA YLLRALSVKG
IAVCVNKLDT VDWSYERFIA IKENILDFLV SKVGFKETMV HIVPVSGLSG ENLIKRDEPK
LLSWYNGPTL MNILDDFVPP TKPVKASLRI TVNDTYRSAK GVCVQGRVES GNVQNNQVLF
NVSTNSDAYV KSIIRNGHPH DWSVAGDNIT MQLTDIDANE IRPGDILTTT SQPVKKTKSF
IAEIQTFDLL RPILSGATLV LHRGRLSAPV VIKLQSVNGK KVRHITSRKT AIVKFTFLDG
SYPICTVDDC KTLGKIILRR EGDTVAAGVI RKV
//
