ID B6K1D1_SCHJY Unreviewed; 729 AA.
AC B6K1D1;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Translation initiation factor IF-2Mt {ECO:0000313|EMBL:EEB07752.2};
GN Name=mti2 {ECO:0000313|JaponicusDB:SJAG_02856};
GN ORFNames=SJAG_02856 {ECO:0000313|EMBL:EEB07752.2};
OS Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB07752.2, ECO:0000313|Proteomes:UP000001744};
RN [1] {ECO:0000313|EMBL:EEB07752.2, ECO:0000313|Proteomes:UP000001744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
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DR EMBL; KE651166; EEB07752.2; -; Genomic_DNA.
DR RefSeq; XP_002174045.2; XM_002174009.2.
DR AlphaFoldDB; B6K1D1; -.
DR STRING; 402676.B6K1D1; -.
DR EnsemblFungi; EEB07752; EEB07752; SJAG_02856.
DR GeneID; 7048540; -.
DR JaponicusDB; SJAG_02856; mti2.
DR VEuPathDB; FungiDB:SJAG_02856; -.
DR eggNOG; KOG1145; Eukaryota.
DR HOGENOM; CLU_006301_5_2_1; -.
DR OMA; RYYNVIY; -.
DR OrthoDB; 169393at2759; -.
DR Proteomes; UP000001744; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:EnsemblFungi.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0070124; P:mitochondrial translational initiation; IBA:GO_Central.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF20; TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF11987; IF-2; 1.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:EEB07752.2};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000001744}.
FT DOMAIN 176..345
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 729 AA; 79893 MW; 4B8AB6B129BDF021 CRC64;
MNGKLVTDIL FHVHRTVNIG ARWRLGLELQ NLAPKRFLSA HGQYRKENKC DRPFSCPENK
CKRQTHGILM AETSFVPVRS FASSHKRVVP VLELPPVVRV SQLASMMRIN TSRLVRLLRK
VVDKNVTSEY LLPFEDSSMV AVELGFDARQ ASFASSKLLK LAEKGESRLN SDSLPLRPPI
VTIMGHVDHG KTTLLDALRK SSIVATEHGG ITQRIGAFSV PFSKGAQQIT FIDTPGHAAF
EEMRKRGASV TDIVVLVIAG DDGVQPQTVE ALKHIQAAGV PMVVALTKCD RPGFSADKVQ
KQLLEHGVQT EEFGGDTQVC CVSGVTGQGL EELESCILAL AEVLDIRASK KAAVEGWIIE
SSVSKGQGIQ ASVLIKQGTV RLGSFLVCKE SYAKVRLLLK NGNVRCKQAF PGEAVQVSSF
KSIPPAGVRV FSVSKESEAK AFIEAAQREK HLLSQTDLAH KQNEQQISAA KLRAKKSRLD
RRGMLLSYWD KELVRDEQKQ SSSTDVSNSS HSSSAPSTYS IIIKAAESGA LEAAEAYLNG
IQYGSTKLQP VYTALGPLTE TDINNAHVAK ASIAVFGMDV SNGILASARR KEIQVIQSNV
IYELYEKVKD SFRETLPPIT VTRIDAEALV LALFPHNDKR STSVVLGCRV TNGKFCDAHA
IRVMRNGRNI WTGTIESMRH LRDEVHSVAK GKEFGILPHI PKEFADDLPA FQPGDIVQSF
YNEQVAPAF
//
