ID B6K3H4_SCHJY Unreviewed; 656 AA.
AC B6K3H4;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 6 {ECO:0000256|ARBA:ARBA00020973, ECO:0000256|RuleBase:RU365075};
DE Short=COG complex subunit 6 {ECO:0000256|RuleBase:RU365075};
DE AltName: Full=Component of oligomeric Golgi complex 6 {ECO:0000256|ARBA:ARBA00031348, ECO:0000256|RuleBase:RU365075};
GN Name=cog6 {ECO:0000313|JaponicusDB:SJAG_03158};
GN ORFNames=SJAG_03158 {ECO:0000313|EMBL:EEB08031.1};
OS Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB08031.1, ECO:0000313|Proteomes:UP000001744};
RN [1] {ECO:0000313|EMBL:EEB08031.1, ECO:0000313|Proteomes:UP000001744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- FUNCTION: Acts as a component of the peripheral membrane COG complex
CC that is involved in intra-Golgi protein trafficking. COG is located at
CC the cis-Golgi, and regulates tethering of retrograde intra-Golgi
CC vesicles and possibly a number of other membrane trafficking events.
CC {ECO:0000256|ARBA:ARBA00043873}.
CC -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC is involved in intra-Golgi protein trafficking. COG is located at the
CC cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles
CC and possibly a number of other membrane trafficking events.
CC {ECO:0000256|RuleBase:RU365075}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex.
CC {ECO:0000256|RuleBase:RU365075}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004395, ECO:0000256|RuleBase:RU365075};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004395,
CC ECO:0000256|RuleBase:RU365075}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000256|ARBA:ARBA00011023,
CC ECO:0000256|RuleBase:RU365075}.
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DR EMBL; KE651167; EEB08031.1; -; Genomic_DNA.
DR RefSeq; XP_002174324.1; XM_002174288.2.
DR AlphaFoldDB; B6K3H4; -.
DR STRING; 402676.B6K3H4; -.
DR EnsemblFungi; EEB08031; EEB08031; SJAG_03158.
DR GeneID; 7048504; -.
DR JaponicusDB; SJAG_03158; cog6.
DR VEuPathDB; FungiDB:SJAG_03158; -.
DR eggNOG; KOG3758; Eukaryota.
DR HOGENOM; CLU_011361_1_0_1; -.
DR OMA; HSCLDFF; -.
DR OrthoDB; 276556at2759; -.
DR Proteomes; UP000001744; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IBA:GO_Central.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR010490; COG6.
DR InterPro; IPR048369; COG6_C.
DR InterPro; IPR048368; COG6_N.
DR PANTHER; PTHR21506; COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6; 1.
DR PANTHER; PTHR21506:SF0; CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6; 1.
DR Pfam; PF20653; COG6_C; 1.
DR Pfam; PF06419; COG6_N; 1.
DR SMART; SM01087; COG6; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU365075};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365075};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU365075};
KW Reference proteome {ECO:0000313|Proteomes:UP000001744};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365075}.
FT DOMAIN 50..161
FT /note="Conserved oligomeric complex COG6 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06419"
FT DOMAIN 196..646
FT /note="Conserved Oligomeric Golgi complex subunit 6 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF20653"
SQ SEQUENCE 656 AA; 75084 MW; C6C7CE228A81F327 CRC64;
MENAGTALLN GSATRGSGYS FRRAVTQRLL QLSTIHLKDE DFVKSVRQLD SRNFAVDHEN
IRQLQIDIRT DALWTNGTVI REFSEFASHL ETIQTLLNRL NSLYSQRETS VLEKLSGVQQ
LSEKYKTLED QKAEALRKLE YLQFCRENFF LSEEDVYHLV SSDIVDQRFY SILEKAQTIS
NNCTSLFAIN AEETNEAATK VMKAMSQYID EAFEKLFRYV KTELNDMETS RNLEFHPDLK
SAFAALFAKP EMLNKTLDLI VQARQRVLYV AFVMALETGD PNTFSRPIEL SAPDPKRFVN
DIIAWLHQTI AGEKELIETL FQARRKKINE SENSWWDSLE SLEMNSKMLM DENLYGVCKA
IVSRVQTSIL ETEDLITIYG LIEIFGFYRE LLSSTIHEHS TVLTSLKTLE DFAFKRLQSL
IDDELYHVKA SALNIPADLL PPQFVIRFMK SLASILNVRK NSYSSQFVDV NELVATLEST
VSSLFEISDR CSKRLLPHKR YIFLLNVVDC CYSYIEPYSG TESLQKLLND KQAKLADELT
LQLHTEFCSQ SSLIDLSFCF QSGDESFIEE ALEKVNWSKI RNEFGSFLVT TFADATTDLL
LLTSPTVQTN VQANSVQLFF NDVTKVKNCL EKFSKSSEFP FSLNELQIAL GIENTA
//
