ID B6K552_SCHJY Unreviewed; 690 AA.
AC B6K552;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=UDP-glucose 4-epimerase {ECO:0000256|ARBA:ARBA00013189};
DE EC=5.1.3.2 {ECO:0000256|ARBA:ARBA00013189};
GN ORFNames=SJAG_03818 {ECO:0000313|EMBL:EEB08656.1};
OS Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB08656.1, ECO:0000313|Proteomes:UP000001744};
RN [1] {ECO:0000313|EMBL:EEB08656.1, ECO:0000313|Proteomes:UP000001744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC EC=5.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00000083};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000256|ARBA:ARBA00007637}.
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DR EMBL; KE651167; EEB08656.1; -; Genomic_DNA.
DR RefSeq; XP_002174949.1; XM_002174913.2.
DR AlphaFoldDB; B6K552; -.
DR STRING; 402676.B6K552; -.
DR EnsemblFungi; EEB08656; EEB08656; SJAG_03818.
DR GeneID; 7050460; -.
DR JaponicusDB; SJAG_03818; -.
DR VEuPathDB; FungiDB:SJAG_03818; -.
DR eggNOG; KOG1371; Eukaryota.
DR HOGENOM; CLU_007383_22_1_1; -.
DR OMA; KGLYREW; -.
DR OrthoDB; 5489993at2759; -.
DR Proteomes; UP000001744; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IBA:GO_Central.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-KW.
DR CDD; cd09019; galactose_mutarotase_like; 1.
DR CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR018052; Ald1_epimerase_CS.
DR InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR047215; Galactose_mutarotase-like.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005886; UDP_G4E.
DR NCBIfam; TIGR01179; galE; 1.
DR PANTHER; PTHR43725; UDP-GLUCOSE 4-EPIMERASE; 1.
DR PANTHER; PTHR43725:SF51; UDP-GLUCOSE 4-EPIMERASE; 1.
DR Pfam; PF01263; Aldose_epim; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00545; ALDOSE_1_EPIMERASE; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000001744}.
FT DOMAIN 8..337
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
SQ SEQUENCE 690 AA; 76295 MW; E81C2186CC8015E5 CRC64;
MAIDKYILVT GGAGYIGSHT VVELIQRGFK VVVIDSLVNS SYDAIVRAEY IVRSPIPFFK
IDLHDKAALN KVFDDYAIEG VIHFAAFKAV GESAQKPLEY YENNVGGAVA LLEVMSTHGV
KTIVYSSSAT VYGDVSRFKD HNYLPINEKC PTDPVSPYGK TKYAIENIIA DLHSSDNSWR
GAVLRYFNPI GAHPSGLLGE DPLGVPNNLL PYLAQVAVGR RDKLNVFGND YDSRDGTPIR
DYIHVVDLAQ GHVAALEYLK TLEQGQGLYR VWNLGTGKGS TVLEIHAAFS AVVGRELPYN
VVGRRAGDVL NLTADPTRAN TELGWKAKLT VEDACRDLWK WTMENPYGFQ VKNFKWSLFN
DPGAEVNFAS RLNTFTFGDF SVTIANYGAT IQNIAFKGRT VVTSMDKLSL YQSDDNPAFG
ATVGRYANRI RNGTFSIDGV TYHTDKNWRG HTIHGGSRGF GRQFWLGPVA KSDETHGTLE
FLIYDKDGSN GFPADVIATA KFTVDEKSLR LEIEARIPES SPKDVTAVNM TNHVYFNLSS
GETIDGTIIK TCTDTILESD PDYLLPTGRV IQYKQKLSES VDLQPSNPID NCFVAKVDGF
KLDTRGDEMQ TIVEAHHPST GFKLTAATTD PAFQIYTGDF VDIGPYKARA GFCVEAQRYL
EAINNEHWNK QVILRKGEVY GSDTIYTFSV
//
