ID B6K5E8_SCHJY Unreviewed; 1974 AA.
AC B6K5E8;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Helicase sen1 {ECO:0000313|EMBL:EEB08752.1};
GN Name=dbl8 {ECO:0000313|JaponicusDB:SJAG_03923};
GN ORFNames=SJAG_03923 {ECO:0000313|EMBL:EEB08752.1};
OS Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB08752.1, ECO:0000313|Proteomes:UP000001744};
RN [1] {ECO:0000313|EMBL:EEB08752.1, ECO:0000313|Proteomes:UP000001744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
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DR EMBL; KE651167; EEB08752.1; -; Genomic_DNA.
DR RefSeq; XP_002175045.1; XM_002175009.2.
DR STRING; 402676.B6K5E8; -.
DR EnsemblFungi; EEB08752; EEB08752; SJAG_03923.
DR GeneID; 7050555; -.
DR JaponicusDB; SJAG_03923; dbl8.
DR VEuPathDB; FungiDB:SJAG_03923; -.
DR eggNOG; KOG1801; Eukaryota.
DR HOGENOM; CLU_000459_2_0_1; -.
DR OMA; PWHQSEL; -.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000001744; Unassembled WGS sequence.
DR GO; GO:0016604; C:nuclear body; IBA:GO_Central.
DR GO; GO:0030874; C:nucleolar chromatin; IEA:EnsemblFungi.
DR GO; GO:0035861; C:site of double-strand break; IEA:EnsemblFungi.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0001147; F:transcription termination site sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central.
DR CDD; cd18042; DEXXQc_SETX; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR024481; Helicase_Sen1_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF525; HELICASE SENATAXIN-RELATED; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF12726; SEN1_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:EEB08752.1};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000313|EMBL:EEB08752.1};
KW Hydrolase {ECO:0000313|EMBL:EEB08752.1};
KW Nucleotide-binding {ECO:0000313|EMBL:EEB08752.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001744}.
FT DOMAIN 78..761
FT /note="Helicase Sen1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12726"
FT DOMAIN 1272..1557
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 1564..1758
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 956..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1797..1974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1418..1476
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 976..991
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1797..1856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1859..1896
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1897..1917
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1974 AA; 222224 MW; 32A956C5652E0B70 CRC64;
MGNEFSLDEL KAAIRKNQEN AGKESSPNSN KVIELALKFL DEKRKEPHWF CDRRLSIAVR
ECLYLFSFQV EKKVLSWLKV HMTNRLKSCP SCILAYYKLK QEFGNICIDV FHYTKESLSL
VLKRIQDWDI ERLVQLLKTS PKVDSTPNSK PILCAFYEIL YSVELLQSPT LFDLFRVRFT
ESGFLRLSKK LVPGVVYLLF SEDVKLRKWA HGSFNSLEIV SSEEFMPLQG PFLQAMDQIC
DENSQSSLTV FYQALRTLLC HIHKDYFLSL QSSEHDVVQF FFTKRQPSTL GEFAAYLQCF
QQLLKVFEKK IWTIYSQKSA LKYLEDLLQS EIYTKWITEV SQPSDVVTFD GVFSWAKYFI
SSLPILNSLN AVLKLLEHFI ELYKSCNDNG VNHSSLLESI CECFQLLFNE FLKGAGNSNN
LHEIDYSELQ AVSTSTYDRF FDLLDFEHET SIDSEIVYST FGFEIEDGCF WKHLKDVLKD
ERVTLASTLL SSVSEVALAD ELETKSGETD YAEQFHFMLD SFRTALGGIL NSLQDWSLSS
QSSLIKDIRT CRSLFSLSCS PIKDISSTSL FVLKTALDCD SVEDMLHKLL EDHFSEILSA
FNTNLDDWTR IKTFRPARYL LRYAKIITDT FCNRCNGLIV VENKLRVIET NRRAMTTFWS
NIWTVMASVF LRSLYWPAKH SRVLLIDFMR DTLECCLSLL DNLKDFEYFM KGEELSSSTP
SSSSFEQTEL SSKMISNLKE PLGTLCYWLK LNDEALLCNV VAIICKMLRA CKRVELPMSL
NVVSMIEKYA NSSKDHRTIL TKSEREDLLF ALAPYLPEPA TDDDVIMLPE VNTVIDDSIL
EDEKTAVKSP ELDKHVPVIE VEDEQFQLPA LPSVSPQLPS NTLKSDTKNK TNTFSISADI
INNAKKLNER SVTYSAKRQP VVIERKPKPP ASTFNLKKAS ASSTLKQLKQ NFLQSRGPVT
KFGSLPGRPN SVLNRKPPVA SASTSSSDSS DSEGEKPSDG LFSLIKDVDT STTKTVAPRR
GIQLLDPSFS VAKGGSHPVQ QRRTIQQSAQ ITKARLFPDV SKFYKTLLSW NPACDSEIPP
TEAIAPCKRI SATYTSVENY INTFEPLLFH ELWAQMVRSK VDNNSPPVEV QLLSRSTVDA
FIDLFVVAPD STLGLGIGDS DVCAMSKSKN PSHPSAGEPA FLVKVQSITK KKSGLEVTLR
TLPTVSAMQL FRPNLSFYVQ KLFSITTNLR EYSSLRALSF YDVSEDIIKA RCNPCDLSLQ
PPQLKRVMES YHVNEPQALA IHAACARTGF TLVQGPPGTG KTKTILGIVS ALLTSGGQGR
RFDAPGQNGN TQPGTKKVLI CAPSNAAIDE ILLRLKDGIF DHEGIKFKPK ILRVGYSESI
NPHVKEFTLD EKMQEQMQVL NLKKNQDNGE SMQVRKRHDE ILKERDALRA QLEKARNSGI
NDPAVEMKLR EVMKTKNQLE QRLDDMRRQQ GIANRNMDIA KKQIQSQLLK DAEIICSTLS
ASGHDILLKS GISFPSVIID EAAQAVELSA LIPLKYGCER CIMVGDPNQL PPTVLSKTAS
QNGYSESLYV RMHKQNPNSS FLLSIQYRMH PEISRFPSSY FYGSRLLDGP DMQKLTARPW
HHDPTFGIYR FFDVRTRESS SITKSVYNPE EASFVLTLYD KLVQDYINVD MEGKVGIVTP
YRRQLQELRM QFERRYGPLI FKRVDFNTVD GFQGQEKDII LFSCVRGDMG GGIGFLSDTR
RLNVALTRAK SSLYIIGNVG TLTKDKMWSA LITDAQTRSC LVTSSIDQLR RSQSYAIQSS
QSIQTPKAIP SSAISSPISA PSPIPRSLSS ASAPPKQYTQ TNASPQANSS KLGSQKRPSI
ARKHSESKHE KKRKTSEEYS SRHGHKKRDK ESHQDSPNRF LSPVSQTPAT GASPTPLPSA
SGMHPARLQR LQEPQPIAPV APPRKLKSKL ALAALARGFT PNGRAEKPKP SGNT
//
