ID B6K5Y5_SCHJY Unreviewed; 705 AA.
AC B6K5Y5;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Morphology protein {ECO:0000313|EMBL:EEB08939.2};
GN Name=mam301 {ECO:0000313|JaponicusDB:SJAG_04111};
GN ORFNames=SJAG_04111 {ECO:0000313|EMBL:EEB08939.2};
OS Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB08939.2, ECO:0000313|Proteomes:UP000001744};
RN [1] {ECO:0000313|EMBL:EEB08939.2, ECO:0000313|Proteomes:UP000001744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KE651167; EEB08939.2; -; Genomic_DNA.
DR RefSeq; XP_002175232.2; XM_002175196.2.
DR AlphaFoldDB; B6K5Y5; -.
DR STRING; 402676.B6K5Y5; -.
DR EnsemblFungi; EEB08939; EEB08939; SJAG_04111.
DR GeneID; 7049281; -.
DR JaponicusDB; SJAG_04111; mam301.
DR VEuPathDB; FungiDB:SJAG_04111; -.
DR eggNOG; KOG2118; Eukaryota.
DR HOGENOM; CLU_011310_3_1_1; -.
DR OMA; KSHMILI; -.
DR OrthoDB; 248389at2759; -.
DR Proteomes; UP000001744; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030026; P:intracellular manganese ion homeostasis; IBA:GO_Central.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR PANTHER; PTHR12064:SF100; PROTEIN MAM3; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000001744};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 56..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 48..231
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 313..377
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 473..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 667..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..705
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 705 AA; 76992 MW; 48B1CA12150263A1 CRC64;
MLSRLRYLIF SISYFSKLVH SIPVGENQLH GFSGDEKAGM SVLPALPNVS EYMGRLLVSV
FLILLGGVFA GLTIALMGVD DLHLEVLARS GDEKEQLYSK KVLGLLRRGK HWVLVTLLLG
NVIVNETLPI VFDSIIGGGW PAVILSTAMI VIFGEVIPQA VCVRYGLMIG AKLEPLVLFM
MYLLYPIAYP MALVLDACLG KAEGTMYKKS GLKTLVTLHR DLGLDKLNQD EVTIINAVLD
LREKPARTIM TPIENVFTLS ADRILDEALI EEIVFAGYSR IPIHKPGFPT DFIGMLLIKT
LLGYDPEDRL PVYSFPLATL PETWPETSCL DLLNYCQEGK SHMILVSTSP GENHGAIGVI
TLEDIVEELI GEEIIDETDV YIDVRQKLRR VNNTNAFWQR LFHRAHMKHL DALRKSPRPD
IQGKGTPNEY VPILNPKNAA INPKIHSTER IKVKPASNAL ALGRSYGSID THRRAASEAA
DGKVKSVNAE LQRNTSSSPD LQKSALLDST TTATSTTAEP SSTVSAPAVT VSKESEQPSK
DQATTSPANT VNASSPHSSP TVEAGSSEQL KEQSAVYHAK PHGSVSSSYS GRRVRLGNVI
ESRHVTEDGV ERVVVAPTDS VHGCGDDVVE MKEVNGILVP KVSTSTTPSN IPSRPISRAG
SDAFSLGTSL GTGETSKSLS NLSAKSFASR VKRNRRRRHR RRTRR
//
