ID B6K653_SCHJY Unreviewed; 420 AA.
AC B6K653;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=tRNA (Guanine-N2-)-methyltransferase catalytic subunit Trm11 {ECO:0000313|EMBL:EEB09007.2};
GN Name=trm11 {ECO:0000313|JaponicusDB:SJAG_04181};
GN ORFNames=SJAG_04181 {ECO:0000313|EMBL:EEB09007.2};
OS Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB09007.2, ECO:0000313|Proteomes:UP000001744};
RN [1] {ECO:0000313|EMBL:EEB09007.2, ECO:0000313|Proteomes:UP000001744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC tRNA methyltransferase complex that mediates the methylation of the
CC guanosine nucleotide at position 10 (m2G10) in tRNAs.
CC {ECO:0000256|ARBA:ARBA00002425}.
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DR EMBL; KE651167; EEB09007.2; -; Genomic_DNA.
DR RefSeq; XP_002175300.2; XM_002175264.2.
DR AlphaFoldDB; B6K653; -.
DR STRING; 402676.B6K653; -.
DR EnsemblFungi; EEB09007; EEB09007; SJAG_04181.
DR GeneID; 7050576; -.
DR JaponicusDB; SJAG_04181; trm11.
DR VEuPathDB; FungiDB:SJAG_04181; -.
DR eggNOG; KOG2671; Eukaryota.
DR HOGENOM; CLU_029646_3_0_1; -.
DR OMA; QAFNKWS; -.
DR OrthoDB; 5488599at2759; -.
DR Proteomes; UP000001744; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043528; C:tRNA (m2G10) methyltransferase complex; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0160102; F:tRNA (guanine(10)-N2)-methyltransferase activity; IEA:EnsemblFungi.
DR GO; GO:0030488; P:tRNA methylation; IEA:EnsemblFungi.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR13370:SF3; TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG; 1.
DR Pfam; PF01170; UPF0020; 1.
DR PIRSF; PIRSF017259; tRNA_mtfrase_TRM11; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51627; SAM_MT_TRM11; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EEB09007.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001744};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EEB09007.2};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 177..293
FT /note="UPF0020"
FT /evidence="ECO:0000259|Pfam:PF01170"
SQ SEQUENCE 420 AA; 48425 MW; DFA9C45C4EEB1160 CRC64;
MKCYILHFSS THKDFHLPEL ETLSKIENVP FSITERSSNP FWIVQIEDDE SARKLVKRSI
FCKGVYELYG CSDTLDNLHE LLKNMQPKPW ELYSQTTYKF SIESYGKHLT MEEQLNVINQ
FGYLHLNGKV SMKSPDCIFT VLEDNEKKSD SKVKAYFCRK LGVGSRDAID KFDLKQRRYI
GITSFESELS LVTAQMAMAG PAKVVYDPFV GTGSFLYTCS FFGAHTIGSD IDGRQMRGKN
SVSIRENIAQ YNLQSSFLDV FTSDITHCPI RESFLLDAIV CDPPYGVRAG AKRIASIQNI
IKDKDTKPIL HRYPKLEHYE ICDLVKDLVD FAAKRLVDEG RLVLWLPTIT EEYSIDDIPK
HPALRLLYNS AQHFNHWSRR LLTFERLPRA TVVKNNITQN SEHLPAHYKF REKYFGNSPQ
//
