UniProt: B6K6Z6

Database: UniProt
Entry: B6K6Z6_SCHJY

LinkDB:  B6K6Z6_SCHJY 
Original site:  B6K6Z6_SCHJY

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Ontology (16)   
   GO (16)   
Gene (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (24)   
   InterPro (14)   
   Pfam (8)   
   PROSITE (1)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (44)   

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ID   B6K6Z6_SCHJY            Unreviewed;      2361 AA.
AC   B6K6Z6;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   24-JAN-2024, entry version 62.
DE   SubName: Full=U5 snRNP complex subunit Spp42 {ECO:0000313|EMBL:EEB09300.1};
GN   Name=spp42 {ECO:0000313|JaponicusDB:SJAG_04497};
GN   ORFNames=SJAG_04497 {ECO:0000313|EMBL:EEB09300.1};
OS   Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=402676 {ECO:0000313|EMBL:EEB09300.1, ECO:0000313|Proteomes:UP000001744};
RN   [1] {ECO:0000313|EMBL:EEB09300.1, ECO:0000313|Proteomes:UP000001744}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=yFS275 / FY16936 {ECO:0000313|Proteomes:UP000001744};
RX   PubMed=21511999; DOI=10.1126/science.1203357;
RA   Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA   Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA   Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA   Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA   French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA   Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA   Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA   Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA   Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA   Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT   "Comparative functional genomics of the fission yeasts.";
RL   Science 332:930-936(2011).
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DR   EMBL; KE651168; EEB09300.1; -; Genomic_DNA.
DR   RefSeq; XP_002175593.1; XM_002175557.2.
DR   STRING; 402676.B6K6Z6; -.
DR   EnsemblFungi; EEB09300; EEB09300; SJAG_04497.
DR   GeneID; 7051856; -.
DR   JaponicusDB; SJAG_04497; spp42.
DR   VEuPathDB; FungiDB:SJAG_04497; -.
DR   eggNOG; KOG1795; Eukaryota.
DR   HOGENOM; CLU_000380_3_0_1; -.
DR   OMA; ANKWNTS; -.
DR   OrthoDB; 246127at2759; -.
DR   Proteomes; UP000001744; Unassembled WGS sequence.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0000974; C:Prp19 complex; IEA:EnsemblFungi.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:EnsemblFungi.
DR   GO; GO:0005682; C:U5 snRNP; IBA:GO_Central.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   GO; GO:0097157; F:pre-mRNA intronic binding; IBA:GO_Central.
DR   GO; GO:0000386; F:second spliceosomal transesterification activity; IEA:EnsemblFungi.
DR   GO; GO:0030619; F:U1 snRNA binding; IBA:GO_Central.
DR   GO; GO:0030620; F:U2 snRNA binding; IBA:GO_Central.
DR   GO; GO:0030623; F:U5 snRNA binding; IBA:GO_Central.
DR   GO; GO:0017070; F:U6 snRNA binding; IBA:GO_Central.
DR   GO; GO:0000350; P:generation of catalytic spliceosome for second transesterification step; IEA:EnsemblFungi.
DR   GO; GO:0000389; P:mRNA 3'-splice site recognition; IEA:EnsemblFungi.
DR   GO; GO:0000395; P:mRNA 5'-splice site recognition; IEA:EnsemblFungi.
DR   GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IBA:GO_Central.
DR   CDD; cd08056; MPN_PRP8; 1.
DR   CDD; cd13838; RNase_H_like_Prp8_IV; 1.
DR   Gene3D; 1.20.80.40; -; 1.
DR   Gene3D; 3.30.420.230; -; 1.
DR   Gene3D; 3.90.1570.40; -; 1.
DR   Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR   Gene3D; 3.30.43.40; Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain; 1.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR012591; PRO8NT.
DR   InterPro; IPR012592; PROCN.
DR   InterPro; IPR012984; PROCT.
DR   InterPro; IPR027652; PRP8.
DR   InterPro; IPR021983; PRP8_domainIV.
DR   InterPro; IPR043173; Prp8_domainIV_fingers.
DR   InterPro; IPR043172; Prp8_domainIV_palm.
DR   InterPro; IPR019581; Prp8_U5-snRNA-bd.
DR   InterPro; IPR042516; Prp8_U5-snRNA-bd_sf.
DR   InterPro; IPR019580; Prp8_U6-snRNA-bd.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR019582; RRM_spliceosomal_PrP8.
DR   PANTHER; PTHR11140; PRE-MRNA SPLICING FACTOR PRP8; 1.
DR   PANTHER; PTHR11140:SF0; PRE-MRNA-PROCESSING-SPLICING FACTOR 8; 1.
DR   Pfam; PF01398; JAB; 1.
DR   Pfam; PF08082; PRO8NT; 1.
DR   Pfam; PF08083; PROCN; 1.
DR   Pfam; PF08084; PROCT; 1.
DR   Pfam; PF12134; PRP8_domainIV; 1.
DR   Pfam; PF10598; RRM_4; 1.
DR   Pfam; PF10597; U5_2-snRNA_bdg; 1.
DR   Pfam; PF10596; U6-snRNA_bdg; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR   PROSITE; PS50249; MPN; 1.
PE   4: Predicted;
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW   mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001744};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT   DOMAIN          2126..2259
FT                   /note="MPN"
FT                   /evidence="ECO:0000259|PROSITE:PS50249"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..30
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..51
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2361 AA;  274807 MW;  B8FB7EB73F7506EE CRC64;
     MAFLPPGPPP PRPPGYEPPG APPPPPPPED TSEEKPSKFA KNASTDKVIQ ERVRKWRTMQ
     KLKYGPKRKQ GYVQTEKAPL PPEHLRKIMK DRGDMSSKKY RSDKRSYLGA LKYLPHAILK
     LLENIPMPWE EYREVPVLYH VTGAITFVNE VPRVIEPQYI AQWGTMWVMM RREKRDRKNF
     KRLRFPPFDD EEPPFSIDQL LDLEPLEAIR MDLDEEDDAP VYDWFYDHRA LEGTRHINGS
     TYKRWKLNLP QMANLHRLAY QLLSDLRDNN YFYLFNDKSF FTAKALNVAI PGGPKFEPLY
     KDEAPESEDW DEFNDIYKLI IRYPLRTEYR VAFPYLYNSR VRSVRVSEYH QPPNVFVPPE
     DPDLPAFFWD PLINPITSRQ LDTFVLEKSH EDDVFDEGDD FEVPFDPFFN DEELETEDTV
     SALTLWWAPH PFNKRSGQTK RAQDVPLVKH WYLEHCPPNQ PVKVRVSYQK LLKTHVLNSL
     HTPYPKSHTN RSLFRQLKNT KFFQTTTIDW VEAGLQVCRQ GYNMLQLLIH RKGLTYLHLD
     YNCNLKPTKT LTTKERKKSR FGNAFHLMRE ILRLTKLIVD SHVQYRLGNI DAYQLADGLH
     YIFNHVGQLT GMYRYKYRLM RQIRACKDLK HLIYYRFNTG PVGKGPGCGF WAPSWRVWLF
     FLRGIVPLLE RWLGNLLARQ FEGRHSTGIA KRVTKQRVDS HQDLELRAAV LNDILDMIPE
     GIRQGKSKTI LQHLSEAWRC WKANIPWRVP GLPAPIENMI LRYVKAKADW WISVAHFNRE
     RIRRGATVDK TVAKKNLGRL TRLWLKAEQE RQHNYLKDGP YVTSDEAVAI YTSVVHWLES
     RKFQPIPFPP LSYKHDTKLL VLALERLKEA YSVKGRLNQS QREELALIEQ AYDNPHEMLS
     QIKRRLLTMR TFKEVGIEFM DMYSHLVPVY SVDPMEKICD AYLDQYLWFE ADRRHLFPSW
     IKPSDTEPPP LLVYKWCQGV NNLQDVWETS EGECNVLLET QFSKAFEKVD LTLLNRLLSL
     LMDTNLASYC TAKNNVVLSY KDMSHTNSYG LVRGLQFSSF VWQFYGLVLD ILVLGLQRAS
     EIAGPPEAPN EFLQFKNKET ETKHPIRLYT RYIDKLYIMF RFTADEARTL IQRYLNENPD
     PTNSNIVNYS KGKKNCWPRD ARMRLMKHDV NLGRAVFWEI RNRLPRSLTT LEWDDTFPSV
     YSKDNPNLLF SMAGFEVRIL PKIRQNEEFS LKDGVWNLSN NVTKERTAQA FVRVTEDEIQ
     RFNNRIRQIL LSSGSTTFTK IANKWNTALI ALMTYFREAA ISTPELLDLL VKCESKIQTR
     VKISLNSKMP SRFPPAVFYS PKELGGLGML SMGHILIPQS DLRWSKQTDT GITHFRSGMT
     TNGEHLIPNL YRYIQPWESE FVDSQRVWAE YAMKRQEALQ QNRRLTLEDL EDSWDRGIPR
     INTLFQKDRH TLAYDKGWRI RTEFKQYQLL KNNPFWWTSQ RHDGKLWQLN NYRVDVIQAL
     GGVEGILEHT MFKATGFPSW EGLFWEKASG FEESMKFKKL TNAQRSGLNQ IPNRRFTLWW
     SPTINRANVY VGFQVQLDLT GIMMHGKIPT LKISLIQIFR SHLWQKIHES VVWDLCQVFD
     QELESLQIET VQKETIHPRK SYKMNSSCAD ILLFAAYKWN VSRPSLLNDN RDVLDGTTSN
     KYWVDVQLRF GDYDSHDIER YTRAKFLDYT TDSQSMYPSP TGVLIGIDLC YNMHSAYGNW
     IPGMKPLIQQ SMNKVMKANP ALYVLRERIR KGLQLYASEP QEQYLSSSNY AELFSNQIQL
     FVDDTNVYRV TIHKTFEGNL TTKPINGAIF IFNPRTGQLF LKIIHTSVWA GQKRLGQLAK
     WKTAEEVAAL IRSLPVEEQP RQIIVTRKGM LDPLEVHLLD FPNITIKGSE LQLPFQAIIK
     LERINDLILR ATEPQMVLFN LYDDWLQSIS SYTAFSRLIL ILRALNVNTE KTKLILRPDK
     TVTTKEHHIW PSLDDQQWLD VEPQLRDLIL ADYAKKNNVN VASLTNSEVR DIILGMAITA
     PSLQRQQIAE IEKQGRDSAQ VTATTTKTTN VHGEELVVTT TSAYENERFS SKTEWRNRAI
     SASTLHLRTK NVYVNSDNIS DDSKFTYILP KNILRKFVVI SDLRTQIAGF LYGRSPPDND
     SIKEVQCIAL VPQLGSIKNV QLPTKLPHEI GAPIVDGLEP LGWIHTQNME LPYLSSADVT
     TQAKYMTDHP EWGDKAITLT VSFIPGSISL AAYGLRPEGI DWGSKNMDIN SDEAIGYDPK
     MIKKCQLLLS DRITGFFLTP EEDVWNYNFN GASFSANMTY AMKLDVPLPF FALDHRPTHV
     INYTELEANE HYEEDRPDAF A
//

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