ID B6KHL5_TOXGV Unreviewed; 348 AA.
AC B6KHL5; A0A0F7VFJ4; B9QCT7; S8ES99;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=DNA-directed RNA polymerase I subunit RPA12 {ECO:0000256|ARBA:ARBA00018784};
GN ORFNames=BN1205_001770 {ECO:0000313|EMBL:CEL78617.1}, TGVEG_250060
GN {ECO:0000313|EMBL:ESS34452.1};
OS Toxoplasma gondii (strain ATCC 50861 / VEG).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=432359 {ECO:0000313|EMBL:ESS34452.1, ECO:0000313|Proteomes:UP000002226};
RN [1] {ECO:0000313|EMBL:ESS34452.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS34452.1};
RA Paulsen I.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50861 / VEG {ECO:0000313|Proteomes:UP000002226};
RA Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT "Annotation of Toxoplasma gondii VEG.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ESS34452.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS34452.1};
RA Sibley D., Venepally P., Karamycheva S., Hadjithomas M., Khan A., Brunk B.,
RA Roos D., Caler E., Lorenzi H.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CEL78617.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:CEL78617.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
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DR EMBL; LN714502; CEL78617.1; -; Genomic_DNA.
DR EMBL; AAYL02000076; ESS34452.1; -; Genomic_DNA.
DR AlphaFoldDB; B6KHL5; -.
DR STRING; 432359.B6KHL5; -.
DR PaxDb; 5811-TGME49_050060; -.
DR EnsemblProtists; ESS34452; ESS34452; TGVEG_250060.
DR VEuPathDB; ToxoDB:TGVEG_250060; -.
DR eggNOG; ENOG502S7PC; Eukaryota.
DR OMA; MYECTKC; -.
DR Proteomes; UP000002226; Partially assembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd10507; Zn-ribbon_RPA12; 1.
DR Gene3D; 2.20.25.10; -; 1.
DR InterPro; IPR012164; Rpa12/Rpb9/Rpc10/TFS.
DR InterPro; IPR034004; Zn_ribbon_RPA12_C.
DR InterPro; IPR001222; Znf_TFIIS.
DR PANTHER; PTHR11239; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR11239:SF14; DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12; 1.
DR Pfam; PF01096; TFIIS_C; 1.
DR SMART; SM00440; ZnF_C2C2; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR PROSITE; PS51133; ZF_TFIIS_2; 1.
PE 4: Predicted;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000313|EMBL:ESS34452.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002226};
KW Transcription {ECO:0000256|ARBA:ARBA00022478, ECO:0000313|EMBL:ESS34452.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00472}.
FT DOMAIN 305..345
FT /note="TFIIS-type"
FT /evidence="ECO:0000259|PROSITE:PS51133"
FT REGION 94..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 348 AA; 37762 MW; D97BA82E8C6F50D6 CRC64;
MPPPRPSSRS LSSDALLLAQ AASSLVVPLG ADSALSSLLP PESSPCQRLL HQSAQSLDDS
VEYFALLHRL GDDAETVAGP AKFIYQGTGF RRASLSPSGA PEASEREDES AQPRRRPADA
RSLVGVACSQ GVSYDWLLAL GCLNCGRSVT VADDLLPLLE EEDRLDASAA LVCRGCGHHI
APLHGANESD SLVDCMQQSR RRHQAEAADA ELNGERKTDV KRENKGANRG DGGELGETAN
AATASRALTE DGVYLFGQRK QHRLGDFSKR WWQQRFLGER FGERLLEQQL RLVQAFSGAK
KGVVCKETCE ACGHGEAFFS TFQARSADEG MTVMYECVKC GHRRVFNN
//
