ID B6Q3W0_TALMQ Unreviewed; 518 AA.
AC B6Q3W0;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Galactokinase {ECO:0000313|EMBL:EEA27153.1};
GN ORFNames=PMAA_020440 {ECO:0000313|EMBL:EEA27153.1};
OS Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
OS (Penicillium marneffei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441960 {ECO:0000313|EMBL:EEA27153.1, ECO:0000313|Proteomes:UP000001294};
RN [1] {ECO:0000313|Proteomes:UP000001294}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18224 / CBS 334.59 / QM 7333
RC {ECO:0000313|Proteomes:UP000001294};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- SIMILARITY: Belongs to the GHMP kinase family. GalK subfamily.
CC {ECO:0000256|ARBA:ARBA00006566}.
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DR EMBL; DS995899; EEA27153.1; -; Genomic_DNA.
DR RefSeq; XP_002143668.1; XM_002143632.1.
DR AlphaFoldDB; B6Q3W0; -.
DR STRING; 441960.B6Q3W0; -.
DR VEuPathDB; FungiDB:PMAA_020440; -.
DR HOGENOM; CLU_017814_6_2_1; -.
DR OrthoDB; 177392at2759; -.
DR PhylomeDB; B6Q3W0; -.
DR Proteomes; UP000001294; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004335; F:galactokinase activity; IEA:InterPro.
DR GO; GO:0006012; P:galactose metabolic process; IEA:InterPro.
DR GO; GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1440.340; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.3170; -; 1.
DR InterPro; IPR000705; Galactokinase.
DR InterPro; IPR019741; Galactokinase_CS.
DR InterPro; IPR019539; GalKase_N.
DR InterPro; IPR013750; GHMP_kinase_C_dom.
DR InterPro; IPR036554; GHMP_kinase_C_sf.
DR InterPro; IPR006204; GHMP_kinase_N_dom.
DR InterPro; IPR006206; Mevalonate/galactokinase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00131; gal_kin; 1.
DR PANTHER; PTHR10457; MEVALONATE KINASE/GALACTOKINASE; 1.
DR PANTHER; PTHR10457:SF7; N-ACETYLGALACTOSAMINE KINASE; 1.
DR Pfam; PF10509; GalKase_gal_bdg; 1.
DR Pfam; PF08544; GHMP_kinases_C; 1.
DR Pfam; PF00288; GHMP_kinases_N; 1.
DR PIRSF; PIRSF000530; Galactokinase; 1.
DR PRINTS; PR00473; GALCTOKINASE.
DR PRINTS; PR00959; MEVGALKINASE.
DR SUPFAM; SSF55060; GHMP Kinase, C-terminal domain; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00106; GALACTOKINASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000313|EMBL:EEA27153.1};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023011};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001294};
KW Steroid biosynthesis {ECO:0000256|ARBA:ARBA00023011};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol biosynthesis {ECO:0000256|ARBA:ARBA00023011};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transferase {ECO:0000313|EMBL:EEA27153.1}.
FT DOMAIN 41..89
FT /note="Galactokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10509"
FT DOMAIN 160..226
FT /note="GHMP kinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00288"
FT DOMAIN 410..484
FT /note="GHMP kinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08544"
SQ SEQUENCE 518 AA; 57311 MW; 78BFCF3476BD4D87 CRC64;
MAPQQLLVPQ TENIADVYAT DDASARSVAP EIKARWQNLV KQFTETYGKK PDFVARSPGR
VNIIGEHIDY NLYDVLPTAV SVDVIIAVKV VPTEGSEATV KISNVNSQKF PSREFSVPFD
KGVVIDPKKH EWINYFKAGL VGALKFLRKN NPSMKPTSLE IHLDGNVPPG GGISSSAAFV
CASALAVLKA NGHNVSKEDL LDLAVVSERA VGVYSGGMDQ AASIFSQRGF LLYTKFFPKF
SVEHVPIPVA DEEIVFLVAQ SFVTSNKAET GPRHYNLRVA ECTLAAVVLA KQHGIILEKD
NSSLGYSLRN FHEELMRKQG RLQDPLEYQL DSIIQTTTEI FSQEQGYTRE EIAKFLNITV
PELESQFLSS FPVEAERFKL RQRALHCFKE ARRVLDFKAC LSHANKLDIK RIHYLGQLLN
ETQDSCRDDY ECSCPELDQI CEIARRAGTW GSRLTGAGWG GCTVHMLPKS KVDAVSKALR
DEYYSKLSGV TQEQLAQAIV ISKPSNGSFV VHGAALEA
//
