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Database: UniProt
Entry: B6Q4A4_TALMQ
LinkDB: B6Q4A4_TALMQ
Original site: B6Q4A4_TALMQ 
ID   B6Q4A4_TALMQ            Unreviewed;       381 AA.
AC   B6Q4A4;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   05-DEC-2018, entry version 56.
DE   RecName: Full=Saccharopine dehydrogenase [NAD(+), L-lysine-forming] {ECO:0000256|PIRNR:PIRNR018250};
DE            Short=SDH {ECO:0000256|PIRNR:PIRNR018250};
DE            EC=1.5.1.7 {ECO:0000256|PIRNR:PIRNR018250};
DE   AltName: Full=Lysine--2-oxoglutarate reductase {ECO:0000256|PIRNR:PIRNR018250};
GN   ORFNames=PMAA_021170 {ECO:0000313|EMBL:EEA27229.1};
OS   Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
OS   (Penicillium marneffei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces.
OX   NCBI_TaxID=441960 {ECO:0000313|EMBL:EEA27229.1, ECO:0000313|Proteomes:UP000001294};
RN   [1] {ECO:0000313|Proteomes:UP000001294}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18224 / CBS 334.59 / QM 7333
RC   {ECO:0000313|Proteomes:UP000001294};
RX   PubMed=25676766; DOI=10.1128/genomeA.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-saccharopine + NAD(+) = 2-oxoglutarate + H(+) +
CC         L-lysine + NADH; Xref=Rhea:RHEA:12440, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16810, ChEBI:CHEBI:32551,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:57951;
CC         EC=1.5.1.7; Evidence={ECO:0000256|PIRNR:PIRNR018250};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via AAA
CC       pathway; L-lysine from L-alpha-aminoadipate (fungal route): step
CC       3/3. {ECO:0000256|PIRNR:PIRNR018250}.
CC   -!- SIMILARITY: Belongs to the AlaDH/PNT family.
CC       {ECO:0000256|PIRNR:PIRNR018250}.
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DR   EMBL; DS995899; EEA27229.1; -; Genomic_DNA.
DR   RefSeq; XP_002143744.1; XM_002143708.1.
DR   ProteinModelPortal; B6Q4A4; -.
DR   STRING; 441960.XP_002143744.1; -.
DR   EnsemblFungi; EEA27229; EEA27229; PMAA_021170.
DR   GeneID; 7021575; -.
DR   EuPathDB; FungiDB:PMAA_021170; -.
DR   eggNOG; KOG0172; Eukaryota.
DR   eggNOG; COG1748; LUCA.
DR   OrthoDB; EOG092C2ZET; -.
DR   UniPathway; UPA00033; UER00034.
DR   Proteomes; UP000001294; Unassembled WGS sequence.
DR   GO; GO:0004754; F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity; IEA:UniProtKB-EC.
DR   GO; GO:0019878; P:lysine biosynthetic process via aminoadipic acid; IEA:UniProtKB-UniPathway.
DR   CDD; cd12188; SDH; 1.
DR   InterPro; IPR007886; AlaDH/PNT_N.
DR   InterPro; IPR007698; AlaDH/PNT_NAD(H)-bd.
DR   InterPro; IPR027281; Lys1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR11133:SF15; PTHR11133:SF15; 1.
DR   Pfam; PF01262; AlaDh_PNT_C; 1.
DR   Pfam; PF05222; AlaDh_PNT_N; 1.
DR   PIRSF; PIRSF018250; Saccharopine_DH_Lys; 1.
DR   SMART; SM01002; AlaDh_PNT_C; 1.
DR   SMART; SM01003; AlaDh_PNT_N; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR018250};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001294};
KW   Lysine biosynthesis {ECO:0000256|PIRNR:PIRNR018250};
KW   NAD {ECO:0000256|PIRNR:PIRNR018250};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR018250};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001294}.
FT   DOMAIN        7    142       AlaDh_PNT_N. {ECO:0000259|SMART:SM01003}.
FT   DOMAIN      183    313       AlaDh_PNT_C. {ECO:0000259|SMART:SM01002}.
FT   ACT_SITE    205    205       {ECO:0000256|PIRSR:PIRSR018250-1}.
SQ   SEQUENCE   381 AA;  41876 MW;  75FD6321F4BFD22E CRC64;
     MSGTKIWLRA ETKPQEARSA LTPTTTKALL DAGYDVTVEK SSQSIFDDEE YATVGARLVE
     EGSWVKDAPK DTYILGLKEL PEDDFPLEHV HISFAHCYKK QGGWEKVLSR WPRGGGTLLD
     LEFLTDEKGR RVAAFGYSAG YAGSALAIKT WAWQYTHGKD EPLPGETPYA NEGLLISSVK
     EILEAGKKKA GRSPKVLVIG ALGRCGGGAV QFAKDVGIPD EDIIKWDLEE TKKGGPFKEI
     VEDADIFINC IYLSAAIPPF VNAETLASST RTLSVVCDVS ADTTNPHNPI PIYNITTTFD
     KPTVPVTNIP SLGNPELPLD VISIDHLPSL LPRESSEMFS TALLPSLLQL EDRQNARVWV
     QAENLFKQHV STLPEELRKR D
//
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