ID B6Q604_TALMQ Unreviewed; 2628 AA.
AC B6Q604;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Nuclear pore complex subunit Nup192, putative {ECO:0000313|EMBL:EEA28543.1};
GN ORFNames=PMAA_033500 {ECO:0000313|EMBL:EEA28543.1};
OS Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
OS (Penicillium marneffei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441960 {ECO:0000313|EMBL:EEA28543.1, ECO:0000313|Proteomes:UP000001294};
RN [1] {ECO:0000313|Proteomes:UP000001294}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18224 / CBS 334.59 / QM 7333
RC {ECO:0000313|Proteomes:UP000001294};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS995899; EEA28543.1; -; Genomic_DNA.
DR RefSeq; XP_002145058.1; XM_002145022.1.
DR STRING; 441960.B6Q604; -.
DR VEuPathDB; FungiDB:PMAA_033500; -.
DR HOGENOM; CLU_000637_0_0_1; -.
DR OrthoDB; 1830977at2759; -.
DR PhylomeDB; B6Q604; -.
DR Proteomes; UP000001294; Unassembled WGS sequence.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0005643; C:nuclear pore; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR021827; Nup186/Nup192/Nup205.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF126; CULLIN 4, ISOFORM A; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR Pfam; PF11894; Nup192; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001294};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 2259..2501
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 1766..1871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1789..1849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2628 AA; 295824 MW; DBAECD7BCAC4CF67 CRC64;
MDDVDSLGGL RGLYQDLSGI TESSIVNIDR LCLELESHLN DFRTLLDKPG KNDNSRKSVL
TGKLTIDDVE YAINADFQQS TLQLADALNL DEVQAAALFM AAQESAQQLD RTPLITAIMR
FHQRRHFLLE CLRLVFQESF DVEREEIQEL MQNAVAHILQ TKEGTFRNAS LFARKCLASM
EEIEKWLTLI ADQIQKISIV GQAEDADITE AFEYQRTSLM QQHESLGATL CYLFKGTYTS
SEDLRFLLDR MRKIERVDML LVHYVPAIIA ALVQYGSPSG SGTQREARSL NSAVTSTKDN
NAWNLAPFHA AVISWWLTVY SGWYFDSGPA SPLQGVDFDK EAEERTSLFK VCLDDGALEF
MLAICASIQN DEWRHPARNE LVTLLLKDSQ ASVFETDSIS HFMKPLIMEH FDTFTESCIA
NMPNAVRMLK TDEDAQRLDQ ITALRDGLSS SIHRGVLEAR THLETFLVIM AFAFEGRHDA
AQEFWADPDG NLYGFLQWAS KRQTVPRVSA FCEMLCSISE GEDNAVAAHR FLSEEDKHTS
VKFRRSPSMN WVQMFAELQL YATKVTEKPS TSSQILHTRK VENIEMNEPE SPVMLTCYLQ
LIGHLSQQSN TIREWMLHNP SFNVISTLLT LCSGSVPTHL RASAFKTLKA LMTDRTSSHG
NDMWLALDQW ISGAAANASG LAKAPILSNQ PAWHERHAFQ KIGESFDQTN SFVDLVHSLI
TPTSDLPSKL LALPFPEALG ASYRMPGIEP YVDFILGHAF ARKVPDVTEA QGRLLSLNCL
NFMATCLATF NEDLVAIAQQ PAAGPETSIN SSDLNNYIRL HPFARVFEWL FNEDVLKTLF
MSARQDSSEV SRSHCDSVLV QSLVKSLDVM NLVLDLQSTY LNIVRPILRN QGITTKMTVA
NSALASFEDS ILNNLYIIPA LCLYCGSGHE QLTISSMSLL RKLSSSRKLN KSTATGLITW
KSPNRIVEVL STEVNADIVS RPLVHQMEPE PRELDHGHNS PGYLIRENLL GLLNSCLATI
TDRPNIAHLL LGFSCVGNTL DVDSEGLMAK GMSLLHAVIN FVQTYPTDID GSIVSWAIHA
KRMAFEVLKH LWSSKLSSAI VLTELRMNRF LMVSFANQPI VNLNTVWDEF PTATPEFWIS
PSATGFCEFL AYRSHLYEYA TTEIRAASKL GSQSLQLDVL STLLGMSLVE EGETVTHATV
FDLFDFADLK LSHGFSVPQL HYLAGVDFDI CTKEQPDSSI LYDLDAAEEL IKLRRRELAG
GSQVRPQEEE QFQLESEHLL VFLRVTNMER QIHLNRYLAI RSWSELMTTM VISCDMDEGR
RRTFILQAIS LITPKLDVAM VENVPEAIQL AQLAETLISK LDCSVSASHQ GRGSDLIDEK
LYQLFQISIR GICLAIGDVL LRESFYNICA HYISRITTTP GSIHQNLRRQ CQQAVKISGV
SLIEAVSDDA YAGQETCKVS AILLLNLLAE LDAQEHSHLL AETISQSNYL SMFLDSIKTL
SSEFRDAQAH DIPLLISYYH ALLSLLQKLC QTKIGATLVL NAGLFASIRE SRLFAADPDI
GIDMDNPDAL RNYYELLAAM LRVIVSAVFS RGVQNEQIMD QTRTFLGENR SSMIGIFKRF
AKIGGEVSSD NRQVIQNLVT AYVALITAAG FVEGFKSFCD YLPVLKGNFL GWINGGIDSD
WSMSRVSGER SAVSYLRHYV ALVSPSKHCF LPSSPSSINR LRTTKYFVLD RPFDYDGQHS
HVNNLSRRFR QPLPIQNLIS ISVGDTELGG HQSSKRGTVG KRKSVHNEGL QQRNISELFS
SGNQQSSSST PASTAKRLRS STSPSRPSRD NLSSADKMYN FSSSSESPKA ADRFSRKIGG
PTVVSRPSNF TPHTGAKRLV VKNLRSGPRL NQDEYFDGIW TRLSAALDTI FDGGRPAASL
EELYKGAENV CRQGRAAILA KKLQERCKSY VVDNLRQNMV ARAKDGADID ALRSVVDAWA
AWNTKLVTIR WIFYYLDQSF LLHSKDYPVI NEMGLNLFRT HIFLDEALKP KILQGACNMF
ADDRASTGDK SQADSDLLRK AIALFHDLGV YTRHFEHLFL SESEAFLKTW SNKEAESQYI
GTYAENSHLL IEQELTRCEL YALNQNTQQS LSALFDEYLV RDKEDVLLSE SDLKGLMTTE
NKHALGRIYS LLERVKLGHR LKPSFSKYIE EQGATVVFDT ERESEMVVRL LNFKQQLDDT
WAESFHKDES LGHTLREAFE HFMNMTKKTQ ASWGTDNSKT GEMIAKYVDN LLKGGLKVIG
KQAEDAELAD EDTEINKQLD KVLDLFRFVH GKAVFEAFYK NDLARRLLMG RSASDDAEKS
MLARLKTECG SSFTHNLEAM FRDMDLARDE MSSYNAYKTQ RRDKFSLDLS VNVLSAAAWP
TYPDVPVRIP PDIARAINDF EQYYHTKHNG RKLSWKHQLA HCQLRSRFDK GNKEIVVSSF
QAIVLLLFND VTDGETLSYS QIKEATGLSD PELKRTLQSL ACAKYRVLTK KPKGKDVNDT
DEFAYNGAFQ DPKMRIKINQ IQLKETKEEN KTTHERVAAD RHYETQAAIV RIMKSRKTIT
HAELIVEVIK ATRSRGVLEQ AEIKKNIEKL IEKDYMEREE GNRYSYLA
//
