ID B6Q8L6_TALMQ Unreviewed; 893 AA.
AC B6Q8L6;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 13-SEP-2023, entry version 67.
DE SubName: Full=RhoGAP and Fes/CIP4 domain protein {ECO:0000313|EMBL:EEA25820.1};
GN ORFNames=PMAA_069130 {ECO:0000313|EMBL:EEA25820.1};
OS Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
OS (Penicillium marneffei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441960 {ECO:0000313|EMBL:EEA25820.1, ECO:0000313|Proteomes:UP000001294};
RN [1] {ECO:0000313|Proteomes:UP000001294}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18224 / CBS 334.59 / QM 7333
RC {ECO:0000313|Proteomes:UP000001294};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
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DR EMBL; DS995900; EEA25820.1; -; Genomic_DNA.
DR RefSeq; XP_002146367.1; XM_002146331.1.
DR AlphaFoldDB; B6Q8L6; -.
DR STRING; 441960.B6Q8L6; -.
DR VEuPathDB; FungiDB:PMAA_069130; -.
DR HOGENOM; CLU_008201_1_0_1; -.
DR OrthoDB; 1328399at2759; -.
DR PhylomeDB; B6Q8L6; -.
DR Proteomes; UP000001294; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04399; RhoGAP_fRGD2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF17; RHO-GTPASE-ACTIVATING PROTEIN RGD2; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000001294}.
FT DOMAIN 2..434
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 230..298
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 468..666
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 165..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 676..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..843
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 893 AA; 98925 MW; 4594BD51E96A3D5D CRC64;
MPGFADSFWT PDYASGLGIL YSKLQQGIAE NRQILTIASL RADAEEIYSS KLDDIIPAVD
RINTGFSRDE GASVRKAYDG IRGEMIEASK NHQKISSNIR ELVVNPFSRW CDQHAARVQS
SHDDLQARIK DHMKQAELVK KLRSQYFNKC RLVEDLEEEN KFAFQSLEAP SPKGKPPAPK
IVLTDPQESD EPEIFDLGDK SYSEDEIKNI LSDMLNTIKI GEVKVPILGT YQNTSTGADI
VDYLQKKLEA SSISYAERIG QDMVDLGFLR LIGNMGNTFA NSSRMNYQWR SKVFQLTGMP
ENKKPLLRMT SLMSNDEATS SPTISSVSEM LSGWNPLNNP YPDETPAEKL HREAREADER
YKTAVIKLDQ IRCILEEEIV DHLRFMERCE LDRLKAIKSV VLDFSGAISN VIPGLQSTVD
HMMLYQETIQ PLGDLRYFLE NYRTGGFAPK VQPYENYYGS VGDQVFGVDL EARARADRKR
VPVIVTNILT FLDNHYPDLE GDDARRAIWL HDVPLAATHH LRQALNNSAG DPRAILEKYE
IPIVASVLKL YLLELPDSLV SSQVYEIIKT IYSTTANETS EEGRIKVLQS TLGQLRLNNI
ATLDALMTHF TRLIDLTSAD ETYVAALAQA LAPCILRPRL ENTLTLNERH SYRLIRDLFD
HKDAIFGELK RQSSASSTLG AGAGAARPRA ISTDESNRRA AVEARNRAIA SRSRATSPAP
GARHRRDRST DGSQGSGRFP INVSSPHGPD RRNPRQSLDV PSSIDLQIVT DSSKLAEENA
TPNGSSGEVS EKAAPEVSAT ITDFSDPAPV LAADVDAEEG QATNDNNESE GSPTPTASVA
TIEKRDSLTR GRHVRRAGGS HPPADLASKR ANAVTDGELK GVTLEDKPMD DFA
//
