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Database: UniProt
Entry: B6Q950_TALMQ
LinkDB: B6Q950_TALMQ
Original site: B6Q950_TALMQ 
ID   B6Q950_TALMQ            Unreviewed;       640 AA.
AC   B6Q950;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   08-NOV-2023, entry version 65.
DE   RecName: Full=Histone-lysine N-methyltransferase SET9 {ECO:0000256|ARBA:ARBA00015413};
DE            EC=2.1.1.372 {ECO:0000256|ARBA:ARBA00024057};
DE   AltName: Full=Histone-lysine N-methyltransferase set9 {ECO:0000256|ARBA:ARBA00014232};
DE   AltName: Full=SET domain protein 9 {ECO:0000256|ARBA:ARBA00030653};
GN   ORFNames=PMAA_070880 {ECO:0000313|EMBL:EEA26004.1};
OS   Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
OS   (Penicillium marneffei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441960 {ECO:0000313|EMBL:EEA26004.1, ECO:0000313|Proteomes:UP000001294};
RN   [1] {ECO:0000313|Proteomes:UP000001294}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18224 / CBS 334.59 / QM 7333
RC   {ECO:0000313|Proteomes:UP000001294};
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- FUNCTION: Histone methyltransferase that trimethylates 'Lys-20' of
CC       histone H4 to form H4K20me3. {ECO:0000256|ARBA:ARBA00001984}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H(+)
CC         + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:64456, Rhea:RHEA-COMP:15554, Rhea:RHEA-
CC         COMP:15998, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.372;
CC         Evidence={ECO:0000256|ARBA:ARBA00023940};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; DS995900; EEA26004.1; -; Genomic_DNA.
DR   RefSeq; XP_002146551.1; XM_002146515.1.
DR   AlphaFoldDB; B6Q950; -.
DR   STRING; 441960.B6Q950; -.
DR   VEuPathDB; FungiDB:PMAA_070880; -.
DR   HOGENOM; CLU_013724_0_0_1; -.
DR   OrthoDB; 1705992at2759; -.
DR   PhylomeDB; B6Q950; -.
DR   Proteomes; UP000001294; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0140943; F:histone H4K20 trimethyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd10524; SET_Suv4-20-like; 1.
DR   Gene3D; 1.10.10.1700; Histone-lysine N-methyltransferase; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR041938; Hist-Lys_N-MTase_N.
DR   InterPro; IPR025783; Set9_fungi.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR039977; Suv4-20/Set9.
DR   PANTHER; PTHR12977:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE SUV4-20; 1.
DR   PANTHER; PTHR12977; SUPPRESSOR OF VARIEGATION 4-20-RELATED; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS51567; SAM_MT43_SUVAR420_1; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001294};
KW   Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT   DOMAIN          119..233
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   REGION          272..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          362..489
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          589..613
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        284..309
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        380..422
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        435..472
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   640 AA;  72235 MW;  4399EF3821F765BC CRC64;
     MSSKARSTPV ADSRDRLTLS RLANYDDVAT DALIDRAYFW TTIRKNRTKF APGRGILEDV
     VTKILLHKVI VEKNPRAAEQ ELLAMKGLKK YLDSLPNDRE REWFKRHFRK YIHIYLPDCP
     FEISTTNRYT IIEHEASVVA RRNIKKGEEI KYLCGTLVSM TRQEELDLGF NRKDFSIVMS
     SRRKNPSLFL GPARFANHDC NANGRLSTRG NDGMQVIAAR DIELGEEITV SYGEDYFGID
     NCECLCETCE RTVRNGWSPA VSVPTSLVST PFRDAEIDPS NPKKENHASQ TVQLPGNDAH
     VATETITMSE TEHNGKRKFN SDSDSELSSP STPNKRFKFE HRQSKLREEL LLSEVAESIE
     KSPIPVTAQG PPQPIPTLQS PPDQTISTDA EQNTASSTEN DSPSYSSDES NPSISTPATS
     VSGIAPDIKI ESIETSTVPA VSGSSSIQQS PGKDITNITD TSIAQSSQIS EVNERKSRSR
     TSTPRKRALP SVEQVDIIVN RVPGDYTRTD MLLAQRYDRW VDCRTCSAWF VQENAYQTRK
     ECPRCERHSK LYGYRWPKTD PEGSPDEDPR VMDHRTVHRF LSAEEEAKVD RKHRSGVVTP
     TPTPEIIPLD TRSETEFSDY EGRRLTRASR IRARSLRLTQ
//
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