ID   B6QAW4_TALMQ            Unreviewed;       488 AA.
AC   B6QAW4;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   24-JAN-2024, entry version 58.
DE   RecName: Full=Protein SSH4 {ECO:0000256|ARBA:ARBA00017626};
DE   AltName: Full=Protein ssh4 {ECO:0000256|ARBA:ARBA00016528};
GN   ORFNames=PMAA_074150 {ECO:0000313|EMBL:EEA26342.1};
OS   Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
OS   (Penicillium marneffei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441960 {ECO:0000313|EMBL:EEA26342.1, ECO:0000313|Proteomes:UP000001294};
RN   [1] {ECO:0000313|Proteomes:UP000001294}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18224 / CBS 334.59 / QM 7333
RC   {ECO:0000313|Proteomes:UP000001294};
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- FUNCTION: Components of the endosome-vacuole trafficking pathway that
CC       regulates nutrient transport. May be involved in processes which
CC       determine whether plasma membrane proteins are degraded or routed to
CC       the plasma membrane. {ECO:0000256|ARBA:ARBA00025244}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004639}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004639}. Vacuole membrane
CC       {ECO:0000256|ARBA:ARBA00004576}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004576}.
CC   -!- SIMILARITY: Belongs to the SSH4 family.
CC       {ECO:0000256|ARBA:ARBA00006990}.
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DR   EMBL; DS995900; EEA26342.1; -; Genomic_DNA.
DR   RefSeq; XP_002146889.1; XM_002146853.1.
DR   AlphaFoldDB; B6QAW4; -.
DR   STRING; 441960.B6QAW4; -.
DR   VEuPathDB; FungiDB:PMAA_074150; -.
DR   HOGENOM; CLU_016552_1_1_1; -.
DR   OrthoDB; 5479594at2759; -.
DR   PhylomeDB; B6QAW4; -.
DR   Proteomes; UP000001294; Unassembled WGS sequence.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd12910; SPRY_SSH4_like; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035780; SPRY_Ssh4-like.
DR   PANTHER; PTHR12864; RAN BINDING PROTEIN 9-RELATED; 1.
DR   PANTHER; PTHR12864:SF54; SPRY DOMAIN-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001294};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        69..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          124..332
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
FT   REGION          434..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   488 AA;  53140 MW;  CF4D15A8640C8A20 CRC64;
     MPPPDPALLT PAMASPTGFT TSLRVHPQID TNIDMTQFAQ QAVSTGLSPS NPDVMAEVAA
     FSGSTGRGIL IGILSALGSA GVAIVVLTII VFFKYTRHGR ILLDRIGRPG EFDDEEAFAR
     EEAEALETMD DLPRAEYLRA KAFIQANPPE TMHTDISLSQ FLAIQEKGVS AWEFEPELEI
     ANCFVEGRTE IEFFDSECSV QTNLPVPKQN EVYYWEAKIY DKPESTLISI GMTTKPYPLF
     RLPGFHKTSV AYLSTGQRRY NQPFKAPNYG PEYTQGDVIG VGYRPRSGTL FFTRNGKKLE
     DVIHGLKSPN FFPTVGANGP CTVHVNFGQM GFVFIEANVK KWGLAPMTGS LAPPPPYGSE
     QGSILLESGR ETTAPVRGYL DAGYRGSRLI APTSPGPIRS PTDISLAQLA HIPSHEDFGE
     GSSRINVGGA EDGLYITVAS PPPEYSSPES SRNSFSSDHE DGDAGHPPGY TAVAADEEEY
     HSHQDEQR
//