ID B6QFU7_TALMQ Unreviewed; 798 AA.
AC B6QFU7;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=cysteine--tRNA ligase {ECO:0000256|ARBA:ARBA00012832};
DE EC=6.1.1.16 {ECO:0000256|ARBA:ARBA00012832};
DE AltName: Full=Cysteinyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00031499};
GN ORFNames=PMAA_083370 {ECO:0000313|EMBL:EEA24332.1};
OS Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
OS (Penicillium marneffei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441960 {ECO:0000313|EMBL:EEA24332.1, ECO:0000313|Proteomes:UP000001294};
RN [1] {ECO:0000313|Proteomes:UP000001294}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18224 / CBS 334.59 / QM 7333
RC {ECO:0000313|Proteomes:UP000001294};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR EMBL; DS995901; EEA24332.1; -; Genomic_DNA.
DR RefSeq; XP_002147843.1; XM_002147807.1.
DR AlphaFoldDB; B6QFU7; -.
DR STRING; 441960.B6QFU7; -.
DR VEuPathDB; FungiDB:PMAA_083370; -.
DR HOGENOM; CLU_013528_3_1_1; -.
DR OrthoDB; 2140072at2759; -.
DR PhylomeDB; B6QFU7; -.
DR Proteomes; UP000001294; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004817; F:cysteine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006423; P:cysteinyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00672; CysRS_core; 1.
DR Gene3D; 1.20.120.1910; Cysteine-tRNA ligase, C-terminal anti-codon recognition domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR HAMAP; MF_00041; Cys_tRNA_synth; 1.
DR InterPro; IPR015803; Cys-tRNA-ligase.
DR InterPro; IPR015273; Cys-tRNA-synt_Ia_DALR.
DR InterPro; IPR024909; Cys-tRNA/MSH_ligase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR032678; tRNA-synt_1_cat_dom.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR NCBIfam; TIGR00435; cysS; 1.
DR PANTHER; PTHR10890:SF3; CYSTEINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR10890; CYSTEINYL-TRNA SYNTHETASE; 1.
DR Pfam; PF09190; DALR_2; 1.
DR Pfam; PF01406; tRNA-synt_1e; 1.
DR PRINTS; PR00983; TRNASYNTHCYS.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000313|EMBL:EEA24332.1}; ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000001294};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 44..477
FT /note="tRNA synthetases class I catalytic"
FT /evidence="ECO:0000259|Pfam:PF01406"
FT DOMAIN 521..576
FT /note="Cysteinyl-tRNA synthetase class Ia DALR"
FT /evidence="ECO:0000259|Pfam:PF09190"
FT COILED 706..739
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 798 AA; 89793 MW; 4B86541DAE945661 CRC64;
MATARQQPAW QQPAVSPDAK LPSLKIYNSL TKTKVPFVPV DPNGRKVTWY ACGPTVYDDS
HLGHARNYVT TDIIRRILRD YFKFDVHFVM NITDVDDKII LRGRQQYLFN KFVSAHPTID
ATVLDTAKAA YKAYLTKNLR LLDPELPPSK YQAEVEKVYA TVLNGGPLPG NEKPGDDEAK
TKMHIKTLAS AAKAIAEAEI APPALSETFY TDAQDVFLPY LDQLEGSKID ASDYSIFTKL
TRKYEERFMR DLRDLNVLDP DELTRVTEYG PQIAQFVERI VENKFAYVTS DGSVYFDIKA
FEDAGFPYAR LEPWSRSDGK LVAEGEGALT SKTTEKHSPS DFALWKASKP GEPSWSSQWG
KGRPGWHIEC SAMASDRLGK SIDIHSGGID LAFPHHDNEL AQSEAYWNTH THDQWINYFL
HMGHLSIQGS KMSKSLKNFT TIREALERKD WTSRSLRIVF LLGNWNSGIE ITEDVINFGN
SWEDKLNNFF LKMKDLDLLK KSSSGTDQSL GEALEATKAA VNEHLSDSFN TPAAMAAISD
LVTKFNSADK ATVNPEHVEQ MGKWVTSMVN IFGLNGAAPP DASEIGWSGI DVPEEAKPYL
YPLSALRDSL REKALSKEGI SVADIKNIIT SQEDSEAPVS ESAKPYAKVL SDFKDTVSAL
EKPDTIGKEI LGLCDRLRDI DLFDLGIYLE DRENLPALVR PVTKELLQLR EEKAAKLRQK
QLEKEKREKE AREKAEKGRL SHLDMFRTNE YSAWDDEGVP TRDAAGEEIT KSRAKKLKKD
WERQKKLHEA WLVANGAK
//
