ID   B6QS36_TALMQ            Unreviewed;      1294 AA.
AC   B6QS36;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   24-JAN-2024, entry version 63.
DE   SubName: Full=VPS9 domain protein, putative {ECO:0000313|EMBL:EEA20610.1};
GN   ORFNames=PMAA_044430 {ECO:0000313|EMBL:EEA20610.1};
OS   Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
OS   (Penicillium marneffei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441960 {ECO:0000313|EMBL:EEA20610.1, ECO:0000313|Proteomes:UP000001294};
RN   [1] {ECO:0000313|Proteomes:UP000001294}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18224 / CBS 334.59 / QM 7333
RC   {ECO:0000313|Proteomes:UP000001294};
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- SIMILARITY: Belongs to the UPF0507 family.
CC       {ECO:0000256|ARBA:ARBA00007428}.
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DR   EMBL; DS995904; EEA20610.1; -; Genomic_DNA.
DR   RefSeq; XP_002151610.1; XM_002151574.1.
DR   VEuPathDB; FungiDB:PMAA_044430; -.
DR   HOGENOM; CLU_002294_0_0_1; -.
DR   OrthoDB; 1387097at2759; -.
DR   PhylomeDB; B6QS36; -.
DR   Proteomes; UP000001294; Unassembled WGS sequence.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   CDD; cd06093; PX_domain; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR003123; VPS9.
DR   InterPro; IPR037191; VPS9_dom_sf.
DR   PANTHER; PTHR24170; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27; 1.
DR   PANTHER; PTHR24170:SF1; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED; 1.
DR   Pfam; PF13857; Ank_5; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02204; VPS9; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF109993; VPS9 domain; 1.
DR   PROSITE; PS51205; VPS9; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001294}.
FT   DOMAIN          329..485
FT                   /note="VPS9"
FT                   /evidence="ECO:0000259|PROSITE:PS51205"
FT   REGION          64..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          215..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1200..1231
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        218..232
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        233..247
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1294 AA;  144618 MW;  1A24AFE216952127 CRC64;
     MHPLNPFLRA FFRSTVPGQC VPVENHVLLV PTTESLFGSR DKDSNVLYSD LVSSEEFLGS
     HVLRIPNPPG PSHKSDAPNA RDTRTKAKQV TTVNGRTVII KENSIYSNKG FKSLCQAQII
     SDVLYYTPNH NSQPWLIYYI SKPLVGTYDP GKIVPAVPSG NLQVTDAEPS NRNAGDTSSI
     QKRDIKSFAE LLSHFPMIAR QMQPGLDRLF REFGKELGKP LPPPPSQSPA SPSKPEQWPS
     EATDSSQADR LPFNFDEYFA DDEDLMRRSL ETAVTAAIDI FRLVDKQQLS LLGATTDLTG
     PLVERLIEKY IAQQVHETLL FPRLCNFRRT EDVELDTRIR QIEHIDVSQV GIAIEGGLSG
     KTELMNRLSR GVEAFRKMND ATCPQDMLDV LLATIKAVTV SEESDRSLHS SEKQPPAFTV
     NADILVSMLL VVVIRSQVRR LQARLLYMQH FIFVDDVESG EMGYALSTLE AVLTYLVSDY
     APLRKASARN KRLWQATKTG NIRDIRSILE PNENENDEDL SVFDHIDTNS DTLNNEAIKT
     SSLEQQSIRF TLANGNSLEP HTETVENSPL EPPLLAHVFP FQTWEHSTSS NTDKKPRKRV
     SMDVGSISGS SMISLLSRTT TIASTFSGIE GDTSIETLSH THDPAGDSVP MMAVESHQPA
     ALKYLLSLQE YYSIDVILED TNRDGTTLLS AAVQHANRKV VDIITDFLLA ETDIHTISSY
     LEKEDIRGRT VAHYLFSAPY LMSSLGSLLP WQKRDKHGQT PLFAICRSYD HTNYQAMVNE
     ALTVAQRAQD DGQPLRIGDH VDLKGNTLLH IVSDPEIITR ILAECDCDPN ATNERKFTPL
     MVASKYGRVD LMRRLFADPR VDTHITESRG LTAIELAKDD EVRNRIDDMI LFLNPPLNSG
     DITGRITTVV RSLFVEDATV RFILKSGAQA SSDTTSVNGT TYAITTCRRS FADFEHLAKC
     LAVEHPASYI PSISEARSPF QIHSKPSRAI LHDMQGRLDQ FLRILLTHPT FATHEMLWEF
     FLMPELQPDM MIDRSQRKAS VLYESIYDDY SPITPDGIRD TEQFVAHAQE IVRAAHANTR
     SVIRRGHSAQ HAAFDFGDAA SLCASILSTF KPPSNAIPVS HIDAFAQYAA AMSTSSSDSS
     PLLQFLTTLT SVQSTTTAVL SALSRPGRLI YTLSSTNRNL SRSRSSLASS SLPRKFNLNL
     SVLEESRQKN LRELEQKINE SEAQASRLSR EISWNKDVVV SELAGWTSWR EKVGRDAIRA
     FVRATVVQER ERDRRLERCL RNIKELPRLP GSAK
//