ID B6SVX1_MAIZE Unreviewed; 704 AA.
AC B6SVX1; A0A3L6EGY5;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=mRNA m(6)A methyltransferase {ECO:0000256|ARBA:ARBA00012160};
DE EC=2.1.1.348 {ECO:0000256|ARBA:ARBA00012160};
GN Name=100281493 {ECO:0000313|EnsemblPlants:Zm00001eb250310_P001};
GN ORFNames=ZEAMMB73_Zm00001d017566 {ECO:0000313|EMBL:AQK73461.1};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577 {ECO:0000313|EMBL:ACG29004.1};
RN [1] {ECO:0000313|EMBL:ACG29004.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18937034; DOI=10.1007/s11103-008-9415-4;
RA Alexandrov N.N., Brover V.V., Freidin S., Troukhan M.E., Tatarinova T.V.,
RA Zhang H., Swaller T.J., Lu Y.P., Bouck J., Flavell R.B., Feldmann K.A.;
RT "Insights into corn genes derived from large-scale cDNA sequencing.";
RL Plant Mol. Biol. 69:179-194(2009).
RN [2] {ECO:0000313|EnsemblPlants:Zm00001eb250310_P001, ECO:0000313|Proteomes:UP000007305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001eb250310_P001,
RC ECO:0000313|Proteomes:UP000007305};
RX PubMed=19965430; DOI=10.1126/science.1178534;
RA Schnable P.S., Ware D., Fulton R.S., Stein J.C., Wei F., Pasternak S.,
RA Liang C., Zhang J., Fulton L., Graves T.A., Minx P., Reily A.D.,
RA Courtney L., Kruchowski S.S., Tomlinson C., Strong C., Delehaunty K.,
RA Fronick C., Courtney B., Rock S.M., Belter E., Du F., Kim K., Abbott R.M.,
RA Cotton M., Levy A., Marchetto P., Ochoa K., Jackson S.M., Gillam B.,
RA Chen W., Yan L., Higginbotham J., Cardenas M., Waligorski J., Applebaum E.,
RA Phelps L., Falcone J., Kanchi K., Thane T., Scimone A., Thane N., Henke J.,
RA Wang T., Ruppert J., Shah N., Rotter K., Hodges J., Ingenthron E.,
RA Cordes M., Kohlberg S., Sgro J., Delgado B., Mead K., Chinwalla A.,
RA Leonard S., Crouse K., Collura K., Kudrna D., Currie J., He R.,
RA Angelova A., Rajasekar S., Mueller T., Lomeli R., Scara G., Ko A.,
RA Delaney K., Wissotski M., Lopez G., Campos D., Braidotti M., Ashley E.,
RA Golser W., Kim H., Lee S., Lin J., Dujmic Z., Kim W., Talag J., Zuccolo A.,
RA Fan C., Sebastian A., Kramer M., Spiegel L., Nascimento L., Zutavern T.,
RA Miller B., Ambroise C., Muller S., Spooner W., Narechania A., Ren L.,
RA Wei S., Kumari S., Faga B., Levy M.J., McMahan L., Van Buren P.,
RA Vaughn M.W., Ying K., Yeh C.-T., Emrich S.J., Jia Y., Kalyanaraman A.,
RA Hsia A.-P., Barbazuk W.B., Baucom R.S., Brutnell T.P., Carpita N.C.,
RA Chaparro C., Chia J.-M., Deragon J.-M., Estill J.C., Fu Y., Jeddeloh J.A.,
RA Han Y., Lee H., Li P., Lisch D.R., Liu S., Liu Z., Nagel D.H., McCann M.C.,
RA SanMiguel P., Myers A.M., Nettleton D., Nguyen J., Penning B.W.,
RA Ponnala L., Schneider K.L., Schwartz D.C., Sharma A., Soderlund C.,
RA Springer N.M., Sun Q., Wang H., Waterman M., Westerman R., Wolfgruber T.K.,
RA Yang L., Yu Y., Zhang L., Zhou S., Zhu Q., Bennetzen J.L., Dawe R.K.,
RA Jiang J., Jiang N., Presting G.G., Wessler S.R., Aluru S.,
RA Martienssen R.A., Clifton S.W., McCombie W.R., Wing R.A., Wilson R.K.;
RT "The B73 maize genome: complexity, diversity, and dynamics.";
RL Science 326:1112-1115(2009).
RN [3] {ECO:0000313|EMBL:AQK73461.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Seedling {ECO:0000313|EMBL:AQK73461.1};
RG Maize Genome Sequencing Project;
RA Ware D.;
RT "Update maize B73 reference genome by single molecule sequencing
RT technologies.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EnsemblPlants:Zm00001eb250310_P001}
RP IDENTIFICATION.
RC STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001eb250310_P001};
RG EnsemblPlants;
RL Submitted (MAY-2021) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-
CC methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:55584, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=2.1.1.348;
CC Evidence={ECO:0000256|ARBA:ARBA00036277};
CC -!- SIMILARITY: Belongs to the MT-A70-like family. {ECO:0000256|PROSITE-
CC ProRule:PRU00489}.
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DR EMBL; EU956886; ACG29004.1; -; mRNA.
DR EMBL; CM000781; AQK73461.1; -; Genomic_DNA.
DR RefSeq; NP_001147883.1; NM_001154411.2.
DR AlphaFoldDB; B6SVX1; -.
DR SMR; B6SVX1; -.
DR IntAct; B6SVX1; 3.
DR STRING; 4577.B6SVX1; -.
DR PaxDb; 4577-GRMZM2G116563_P01; -.
DR EnsemblPlants; Zm00001eb250310_T001; Zm00001eb250310_P001; Zm00001eb250310.
DR GeneID; 100281493; -.
DR Gramene; Zm00001eb250310_T001; Zm00001eb250310_P001; Zm00001eb250310.
DR KEGG; zma:100281493; -.
DR eggNOG; KOG2098; Eukaryota.
DR HOGENOM; CLU_018702_3_0_1; -.
DR InParanoid; B6SVX1; -.
DR OMA; ARIHNTH; -.
DR OrthoDB; 179166at2759; -.
DR Proteomes; UP000007305; Chromosome 5.
DR ExpressionAtlas; B6SVX1; baseline and differential.
DR GO; GO:0016607; C:nuclear speck; IEA:EnsemblPlants.
DR GO; GO:0036396; C:RNA N6-methyladenosine methyltransferase complex; IBA:GO_Central.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009793; P:embryo development ending in seed dormancy; IEA:EnsemblPlants.
DR GO; GO:0080009; P:mRNA methylation; IBA:GO_Central.
DR InterPro; IPR007757; MT-A70-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12829; N6-ADENOSINE-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR12829:SF2; N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF05063; MT-A70; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51143; MT_A70; 1.
PE 1: Evidence at protein level;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ACG29004.1}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B6SVX1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007305};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ACG29004.1}.
FT REGION 87..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 667..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 704 AA; 77861 MW; 4C2D0A8BDFADA1C4 CRC64;
MEAQTDSAPG GGDDLAIMRE QCRTLEESIS TRREAQLDLI GSLQHLVPDL VPSLEQSLRL
IAAFNGRPFV PTLYPNASVH VQNPNLKPQH RRALPGPARS TRLKTSPGSS PASAAARCAG
TSGGIHAVRT MVAVCLLELV PFAEIDAAAL ARRLQSETSS ASEAERAALA DLAAELGGSA
PAAVALALRR IAEDSGGLQI EEAFIGGKQM TMVWAIDRSK LLKELPESAS VLQIQPPPTP
QVVPLDTDTN IIPRPPPLQQ SDMWGNPMPP MFPRPRGMTM PRIPPGLMPL QRPFMAPGAV
IPMGGGPVPS STQLKLRTEE DDLKDLELLL NKKTYREKQN TKTGEELLDL IHRPTAKETA
VAAKFKTKGG SQLKEYCTNL TKEDCRRQTG SFVACDKVHF RRIIAPHTDT NLGDCSFLDT
CRHTKTCKYV HYELDQTPDV PQMMAGAIAP PRQIKPQRAE YCSEIELGES QWINCDIRNF
RMDILGQFGV IMADPPWDIH MELPYGTMAD DEMRTLNVPT LQTDGLIFLW VTGRAMELGR
ECLELWGYKR VEEIIWVKTN QLQRIIRTGR TGHWLNHSKE HCLVGIKGNP LVNRNIDTDV
IVAEVRETSR KPDEMYAMLE RISPRTRKLE LFARMHNTQA GWLSLGNQLN GVRLVDQGLR
ARYKAAYPDV EVQPPSPPRT STPMDVDQSS SQKVAALDGG ERPA
//
