ID B6VJT9_VITVI Unreviewed; 670 AA.
AC B6VJT9;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5 {ECO:0000256|RuleBase:RU003404};
DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU003404};
GN Name=nad5 {ECO:0000313|EMBL:CAQ77592.1};
OS Vitis vinifera (Grape).
OG Mitochondrion {ECO:0000313|EMBL:CAQ77592.1}.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; Vitales; Vitaceae; Viteae; Vitis.
OX NCBI_TaxID=29760 {ECO:0000313|EMBL:CAQ77592.1, ECO:0000313|Proteomes:UP000009183};
RN [1] {ECO:0000313|EMBL:CAQ77592.1, ECO:0000313|Proteomes:UP000009183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pinot noir / PN40024 {ECO:0000313|Proteomes:UP000009183};
RA Goremykin V., Salamini F., Velasco R., Viola R.;
RT "mtDNA of Vitis vinifera and the issue of rampant horizontal gene
RT transfer.";
RL Mol. Biol. Evol. 0:0-0(2008).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000256|RuleBase:RU003404}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000256|RuleBase:RU003404};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the complex I subunit 5 family.
CC {ECO:0000256|ARBA:ARBA00008200, ECO:0000256|RuleBase:RU003404}.
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DR EMBL; FM179380; CAQ77592.1; -; Genomic_DNA.
DR RefSeq; YP_002608337.1; NC_012119.1.
DR AlphaFoldDB; B6VJT9; -.
DR STRING; 29760.B6VJT9; -.
DR EnsemblPlants; Vitvi00g04781_t001; Vitvi00g04781_P001; Vitvi00g04781.
DR GeneID; 7498671; -.
DR Gramene; Vitvi00g04781_t001; Vitvi00g04781_P001; Vitvi00g04781.
DR KEGG; vvi:7498671; -.
DR InParanoid; B6VJT9; -.
DR OrthoDB; 1463698at2759; -.
DR Proteomes; UP000009183; Mitochondrion.
DR ExpressionAtlas; B6VJT9; baseline.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0009536; C:plastid; IEA:UniProt.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0003954; F:NADH dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR Gene3D; 1.20.5.2700; -; 1.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR NCBIfam; TIGR01974; NDH_I_L; 1.
DR PANTHER; PTHR42829; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5; 1.
DR PANTHER; PTHR42829:SF3; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
DR PRINTS; PR01435; NPOXDRDTASE5.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003404};
KW Mitochondrion {ECO:0000256|RuleBase:RU003404, ECO:0000313|EMBL:CAQ77592.1};
KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU003404};
KW Reference proteome {ECO:0000313|Proteomes:UP000009183};
KW Signal {ECO:0000256|SAM:SignalP};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003404};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003404}; Transport {ECO:0000256|RuleBase:RU003404};
KW Ubiquinone {ECO:0000256|RuleBase:RU003404}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..670
FT /note="NADH-ubiquinone oxidoreductase chain 5"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002851389"
FT TRANSMEM 27..50
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 83..101
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 136..155
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 215..231
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 251..270
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 282..304
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 342..359
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 379..398
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 418..439
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 459..481
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT TRANSMEM 621..642
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003404"
FT DOMAIN 64..114
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 132..420
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
SQ SEQUENCE 670 AA; 74138 MW; 5AB5BE897D297671 CRC64;
MYLLIVFLPL LGSSVAGFFG RFLGSEGSAI MTTTCVSFSS ILSFIAFYEV APGASACYLR
IAPWISSEMF DASWGFLFDS PTVVMLIVVT SISSLVHLYS ISYMSEDPHS PRFMCYLSIP
TFFMPMLVTG DNSLQLFLGW EGVGLASYLL IHFWFTRLQA DKAATKAMPV NRVGDFGLAP
GISGRFTLFQ TVDSSTIFAR ASAPRNSWIS CNMRLNAITL ICILLLIGAA GKSAQIGSHT
WSPDAMEGPT PVSASIHAAT MVTAGVFMIA RCSPLFEYPP MALIVITSAG ATTSFLAATT
GILQNDLKRV IAYSTCSQLG YMIFACGISN YSVSVFHLMN HAFFKALLFL SAGSVIHAMS
DEQDMRKMGG LASSFPFTYA MMLMGSLSLI GFPFPTGFYS KDVILELAYT KYTISGNFAF
WLGSVSVLFT SYYSFRSLFL TFLVPTNSFG RDILRCHDAP IPMAIPLILL ALGSLFVGYL
AKDMMIGLGT HFWANSPFVL PKNEILAESE FAAPTITKLI PIPFSTSGAS VAYNVNPVAD
QFQRAFQTST FCNRLYSFFN KRWFFDQVFN DFLVRSFLRF GYEVSFEALD KGAIEILGPY
GISYTFRRLA ERISQLQSGF VYHYAFAMLL GSTLFVTFYR MWDSLSSWVD NRSSFIFLVS
SFYNNKSSQE
//
