ID B6VKM9_PHOAA Unreviewed; 5457 AA.
AC B6VKM9; C7BTC3;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 24-JAN-2024, entry version 94.
DE SubName: Full=Syringopeptin synthetase b {ECO:0000313|EMBL:CAR66709.1};
GN Name=sypB {ECO:0000313|EMBL:CAR66709.1};
GN OrderedLocusNames=PAU_01491 {ECO:0000313|EMBL:CAQ83583.1};
GN ORFNames=PA-RVA3-3993 {ECO:0000313|EMBL:CAR66709.1};
OS Photorhabdus asymbiotica subsp. asymbiotica (strain ATCC 43949 / 3105-77)
OS (Xenorhabdus luminescens (strain 2)).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Photorhabdus.
OX NCBI_TaxID=553480 {ECO:0000313|EMBL:CAR66709.1};
RN [1] {ECO:0000313|EMBL:CAR66709.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 43949 {ECO:0000313|EMBL:CAR66709.1};
RX PubMed=18838673; DOI=10.1073/pnas.0711114105;
RA Waterfield N.R., Sanchez-Contreras M., Eleftherianos I., Dowling A.,
RA Wilkinson P., Parkhill J., Thomson N., Reynolds S.E., Bode H.B., Dorus S.,
RA Ffrench-Constant R.H.;
RT "Rapid virulence annotation (RVA): identification of virulence factors
RT using a bacterial genome library and multiple invertebrate hosts.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:15967-15972(2008).
RN [2] {ECO:0000313|EMBL:CAQ83583.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC43949 {ECO:0000313|EMBL:CAQ83583.1};
RA Crossman L.C.;
RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CAR66709.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 43949 {ECO:0000313|EMBL:CAR66709.1};
RA Thomson N.R.;
RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CAQ83583.1, ECO:0000313|Proteomes:UP000002747}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43949 / 3105-77 {ECO:0000313|Proteomes:UP000002747}, and
RC ATCC43949 {ECO:0000313|EMBL:CAQ83583.1};
RX PubMed=19583835; DOI=10.1186/1471-2164-10-302;
RA Wilkinson P., Waterfield N.R., Crossman L., Corton C.,
RA Sanchez-Contreras M., Vlisidou I., Barron A., Bignell A., Clark L.,
RA Ormond D., Mayho M., Bason N., Smith F., Simmonds M., Churcher C.,
RA Harris D., Thompson N.R., Quail M., Parkhill J., ffrench-Constant R.H.;
RT "Comparative genomics of the emerging human pathogen Photorhabdus
RT asymbiotica with the insect pathogen Photorhabdus luminescens.";
RL BMC Genomics 10:302-302(2009).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
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DR EMBL; FM162591; CAQ83583.1; -; Genomic_DNA.
DR EMBL; FM211045; CAR66709.1; -; Genomic_DNA.
DR STRING; 291112.PAU_01491; -.
DR KEGG; pay:PAU_01491; -.
DR eggNOG; COG1020; Bacteria.
DR OMA; REDISRW; -.
DR Proteomes; UP000002747; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 3.
DR CDD; cd12117; A_NRPS_Srf_like; 2.
DR CDD; cd19544; E-C_NRPS; 4.
DR Gene3D; 3.30.300.30; -; 5.
DR Gene3D; 3.40.50.980; -; 8.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 5.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 5.
DR Pfam; PF13193; AMP-binding_C; 5.
DR Pfam; PF00668; Condensation; 4.
DR Pfam; PF00550; PP-binding; 5.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 4.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 5.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 9.
DR PROSITE; PS00455; AMP_BINDING; 5.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 5.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 791..865
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1866..1940
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2943..3017
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4018..4092
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5095..5169
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 5457 AA; 602990 MW; 25723AB1A24B7839 CRC64;
MKDNIAEVGN ILQAQTSENV ISVNNTSQQI QNVKNIPQVF TSSESFWCER LASLQPFQLP
FEITGKQTEP RWVMSPWQPP LPKNGEEDSL RTLLQAFVIY LARLTHQTEF QIGWCVEVND
NQADLMPVVP MAVEVVFDEP WSVIADQIDD ELARLTQHRT LSRDLLSRSP LLQAIPALTS
SRPWQIAVSV LKDDRQYDRE VPGELLTLQM NAQGSFRWIY DKNRLSAEVV QRMSEHLQVL
VASKKADDEI PVGQLNLLPE AERTLLLETW NPTETPYPDP LCIHQRFEQQ VEQSPEATAL
VYQEQALSYA ELNICANRLA HQLIALGVAP DQRVAICVTR SPAMVVALLA VLKAGGAYVP
LDSTYPGERL AYILNDAAPS VVLADAVGTA VLGEQALAGL TVLDPNTQFD QPDSNPLVAK
LTPQHLAYVI YTSGSTGQPK GVMVEHQAIY QRYLGFNDTY AVTAQDRVLQ FVAFAFDVSV
EDFFSSLCNG ATLVMRDDSW LASIPEFIAL VRQYRITVMS LPTLFWSELA ARDHGLPLPD
CLRLIIIGGE AVKQHAVQDW FAQEGHRPRL LNGYGPTENT VTVTYKDVLS LADARSIGRP
AKNARIYLLD RDGQPVPLGC TGEMYIGGVG VARGYLNRPT LSAERFMLDP FSPVFGARMY
RTGDLARYLP GGDLEFLGRN DEQVKIRGFR VELGEIETRL VEYPAVQEAV VLALDDGQSK
RLVAYVTVDA HEHERLAARL REHLSTRLPD YMVPAAFVRL DSFPQTPNGK LDRRALPAPG
EEDFARQIYV APQGEAEIIL AALWRELLGI EQISRYDSFF ALGGHSLLGV QMIERLRHRG
LTLTARDLFQ SPVLSELAQV LGRHRAVTVP PNVITPATTA LTPAMLPLID LTQTDIDHIV
EQVPGGIANI QDIYALSPLQ DGILFHHLLE KRGDPYLVLY PVAFANRSLL DRYLTAVQQA
VDRHDILRTA FIWQGLSVPA QVVLRRARLP VTELTLDPAD GPVIDQLTRR FDPDQHRLDL
SQAPLLHFVI AQETDGRWFL LELQHHLIGD HETMEVMHRE VQAYFAGQAD DLPVPVPFRN
LVAEARLGVS QEAHTRFFTD MLAEVDEPTL PFGLTEVHCD GSQMMESHRM LAPDLNDRLR
HQARRAGVSL AALCHLAWAQ VLSHTSGQEK VVFGTVLFGR MAVAEGVDSS MGLFINTLPL
RLDIDDTPIR DSVRAVHLRL AGLLEHEHAS LALAQRCSGV VSGAPLFSAL LNYRHNYQPV
TADEMMDGIE FLGEQERTNY PFVLSVEDFG ESLGLTAQVV QPFEPDRLCG YMQQALESLI
EALEQVPETP VRALNILPET EQKLLLETWN ATEALYPEQL GIHQLFEQQA AKTPQATALI
AGDQTLSYAE LNACANRLAR QLIEQGVCPD EYVVILLPRS VELVVAQLAI LKVGAVYVPI
DPSVPDERRN WLINDCSAKL LITNVQSDIP IGLSVPVFCL SDEKNTNRVE EGINLDLPHS
STGSAYIMYT SGSTGLPKGV IVPHRAVVRL VINNGYAAIG PNDRVAFTAN PAFDASTFEV
WAPLLNGSAL VVIDHDTLLT PQELVQALQA HRITVLWLTI GLFNRLAVEL SPVLPQIKIL
IFGGDIPDLH VIAQVLGNRP PQQLLQAYGP SEGTTFTTMY PIEALPQGVI RLPIGRPIAN
TRVYLLDAYG QPVPLGATGE IYVGGDGVAC GYLNRPELTA ERFLIDPFSH QPDARMYRTG
DLARYLPDGN LEFLGRNDQQ VKIRGFRIEP GEIEARLAEF PVVREAAVLA LSDGQDKRLV
AYVVAPEDEN LVNSLRAHLS AILPDHMVPS AFVRLDAFPL TPNGKLDRRA LPTPDSEAVA
RQIYEAPQGE TEIALAAIWR ELLGIEQVSR HDSFFALGGH SLLAVRMIER LRHLGLTLAA
RDLFQSPVLS ELAQMLGRHR AVMVPANIIT PATTALTPAM LPLIDLTQPE IDSIVGQVPG
GVANIQDIYA LSPLQDGILF HHLLANEGDP YLLAGQMVFA NRTLLDRYLT AVQQVVDRHD
ILRTAFVWQG LSVPAQVVWR QAPLSVTELT LDPIDGPVCD QLAQRFNPRH YRLDLGQAPL
LRFVVAQETD GRWFLLELQH HLIGDHTTMK VMNREVQAYF SGQMDRLPDP VPFRNLVAEV
RLGMSQAEHT RFFTDMLADV DEPTLPFGLA EVHRDGSQEI ESHRMLTIGL SDRLRHQARR
LGVSLAALCH LAWAQVLACT SGQEKVVFGT VLFGRMAAGE GADSGMGLFI NTLPLRLDID
NTPVRDSVRA VHLRLAGLLA HEHASLALAQ RCSGVASGTP LFSSLLNYRH NDQAGNSDAT
MEGIEFLGEH ESTNYPFGLS VEDDGSTLGL IAHVVQPFEP DRICDYVQQA LESLVAALEQ
APETPVQALN ILPEAERTLL LETWNATETA YPDPLCLHQL FEQQAEKIPE ATALVYQEHS
LSYAELNAGA NRLAHQLIAL GIVPEQRVAI CVARSPAMVM AMLAVLKAGA AYVPLDSTYP
AERLAYILND TAPSMVLADT IGRAALGDEA LAGLMVLDPN IQPDQPDDNP QIPALTPQNL
AYVIYTSGST GQPKGVMVEH QALYQRYLGV NELYAVTEQD RVLQFAAFAF DVSVEECFSS
LCNGATLVIR DDSWLASMPE FIALTQQNRI TVAFLPTLFW SELAARDNGW PLPDCLRLII
IGSEAVKRNA IQDWFTQEGH RPQLLNAYGP TENTVTATCK EILSPADDRS IGRPIKNTCV
YLLDRYGQPV PLGCVGEMYI GGVGVAQGYL NRPALSAERF ILDPFSLVSG ARMYRTGDLA
RYLPDGELEF LGRNDQQVKI RGFRVELGEI ETRLVEHPAV QEAAVLALDD ELGKRLVAYV
AAEAHERLTA DLREYLSAIL PDYMIPAAFV RLDSFPQTPN GKLDRRALPA PGEAAFARQV
YEAPQGKIET MLATVWCELL GVEQISRHDS FFALGGHSLL AVRMIERLRR IGLGISVQTL
FQHPTLRVLA QSLVQHNEIR VPDNCITPDT TVLTPDLLPL IDLTQPEIDH IVEQVPGGIV
NIQDIYALSP LQDGILFHHL LEKEGDPYLL VSQMVFADRA LLDRYLTAVQ RTIDRHDILR
TAFIWQGLSV PVQVVWRQAP LSVTELTLNP ANGPVSDQLA RRFDPGRYRL DLSQAPLLRF
VIAQETDGRW FLLELHHHLI GDHETMEVMH REVLAYLTGQ EDSLPAPVPF RNLVAQAQLG
VSQEAHTRFF TDMLAEVDEP TLPFGLAEVH RDGSQVMESH GMLAPELNDR LRSQARRLGV
SLAALCHLAW AQVLSCTSGQ KNVVFGTVLF GRMQAGGSAE NGMGLFINTL PLRLDIDDTP
VRDSVQIAHT RLAGLLAHEH ASLALAQRCS GVRGEIPLFN SLLNYRHNAL PETSDELING
IEFLGGQERT NYPFVLSVED FGESLGLTAQ VVQPFDPESL CGYMQQALES LVEALEQAPE
TPVRELNILP EAEQRLLLET WNATEAPYPE QLCIHQLFEQ QVKKTPEATA LIAGDKTLSY
AELNARANRL ARQLIERGGC PGDHIATLFA RSIELVVAQL AILKVGAVYV PIDPSVPDER
KNWLINDCSA KLLITDGQSD VPVGLSVSLF CLSDETDTLR EEDHINPDLP RSSAGSAYIM
YTSGSTGLPK GVIVPHRAVV RLVINNGYAE IGSDDRVAFT ANPAFDASTF EVWAPLLNGG
ALVIINHATL LTPQELVQDL QAHRITVLWL TIGLFNRLAA ELSPVLPRIK ILIFGGDIPD
LHVIAQVLDN RPPQQLLQAY GPSEGTTFTT MYPIEALQQG VTRIPIGRPI ANTRVYLLDA
YEQPVPPGVI GEIYVGGDGV ALGYFNRPEL TAERFLVDPF SNNPDARMYR TGDLARYLPD
GNLEFLGRND QQVKIRGFRI EPGEIETRLA EYPAVREAAV LALDDGQNKR LVAYVVALED
EGLVNSLRDH LSAILPDYMV PSAFVRLDAF PLTPNGKLDR RALPEPDSEA VARQVYEAPR
GETEIALAAI WRELLGIEQV SRHDSFFALG GHSLLAVRMI ERLRHLGLTL AARDLFQSPV
LSDLAQTLGQ YQAVIVPPNV ITSATTALTP AMLPLIDLTQ PEIDRIVGQV PGGMANIQDI
YALSPLQDGI LFHHLLAKEG DPYLLSGQMA FADRTLLDRY LAAVQQVVDR HDILRTAFIW
EGLSIPAQVV WRQASLSVTE LTLDPADGSV SEQLAERFDP CRHRLDLNQA PLLRFVVAQE
TDGRWIALQL LHHLIGDHTT LDVMNSEVQA YLAGQEDSLP SPVSFRNLVA QAQLGVSQDA
HIRFFTDMLA EVDEPTLPFG LTEVHRDGSQ VTESHRMLAP ELNDRLRSQA RRLGVSLAAM
CHLAWAQVLS RTSGQEQVVF GTVVFGRMAV GKGVDSGMGL FINTLPLRLD IDDTPVRDSV
LATHTRLAGL LEHEHASLAL AQRCSGVQDG GPLFSALLNY RHNDQSMTSD EIVQGIEFLN
ARELTNYPFA LSVEDFGNAL GLTAQVVQPF ESERVCGYMQ QALQSLVEAL EQTPETPVRV
LQILPEAERK LLLKTWNTTE IAYPDQGYIH QLFEQQVERT PDVTALVYEE QTFSYAELNA
RANRQAHQLI ALGVEPDQRV AICVARSPAM VVGLLAVLKA GAAYVPLDPD YPGERLSYIL
SDVSPVILLA DAAGRTALGE KAFTGLTVLD PNVLPDQPDS NPRISELTSR HLAYVIYTSG
STGTPKGVMV EHGQLVNQIT SLNMKWSLSA CDRILQFCNL SFDVCASEIF CAITRGARLV
LRTNQWTLSA QEFWHLCESY EITYIAVPAQ FWRIISNVNE GDIYKGLRII CVGGEAISNH
ELQRWLSVHR EYPVLVNCYG PTEATITSTI SCLNEMVGQA NIIGRPLPNT RVYLLGVDGQ
PVPLGAVGEL YIGGTGVARG YLNRPELTAE RFLTDPFNVD LGARMYRTGD LARYLPDGNL
EFLGRNDHQV KIRGFRVELG EIEARLTEHP AVSKSVVLAL GEGQDKHLVA YVVAPVNEGL
ANSLRTHLNT ILPDYMVPAA FVRLDEFPLT PNGKLDRRAL PAPGNQAFAR QVYEAPLGEV
ETALAAIWSE LLGVKQVSRY DNFFALGGHS LLAMRMTSLA AGRGWVCTLN ALFQFPVLTE
LAAKITSDSL SEPQTSAISV RSDGTEQPLF FVPSGMGDYS YVFGLAQHIQ SGMPIYALPW
PSIDEETMAT MEAQAARMIT LMKAVQPDGP YRLGGYSSGG ILAYAMVQQL LNAGERVNFL
GLIDTSAPHY FGEQPIPPQR HFFSELARQS GEQHPEEVTA LYQRIDELSL VQFIEAAQQL
ALYPANLRAE VIAKRWEQIE NYTQIVRDYQ PQALVITLHQ FYALEPYPET SFMTDEKPEL
VTIEPSLGWE QVMPDTSLRL IAVPGNHFSL LEESENRIAL AQALNMALAI HCDGEGQ
//