ID B6VM19_PHOAA Unreviewed; 517 AA.
AC B6VM19; C7BGV3;
DT 16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=4-hydroxyphenylacetate 3-monooxygenase oxygenase componen (Ec 1.14.14.-) (4-hpa 3-monooxygenase large component) (4-hpa 3 hydroxylase) {ECO:0000313|EMBL:CAR67199.1};
DE SubName: Full=4-hydroxyphenylacetate 3-monooxygenase oxygenase component {ECO:0000313|EMBL:CAQ82282.1};
DE EC=1.14.14.- {ECO:0000313|EMBL:CAQ82282.1};
GN Name=hpaB {ECO:0000313|EMBL:CAR67199.1};
GN OrderedLocusNames=PAU_00189 {ECO:0000313|EMBL:CAQ82282.1};
GN ORFNames=PA-RVA10-2224 {ECO:0000313|EMBL:CAR67199.1};
OS Photorhabdus asymbiotica subsp. asymbiotica (strain ATCC 43949 / 3105-77)
OS (Xenorhabdus luminescens (strain 2)).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Photorhabdus.
OX NCBI_TaxID=553480 {ECO:0000313|EMBL:CAR67199.1};
RN [1] {ECO:0000313|EMBL:CAR67199.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 43949 {ECO:0000313|EMBL:CAR67199.1};
RX PubMed=18838673; DOI=10.1073/pnas.0711114105;
RA Waterfield N.R., Sanchez-Contreras M., Eleftherianos I., Dowling A.,
RA Wilkinson P., Parkhill J., Thomson N., Reynolds S.E., Bode H.B., Dorus S.,
RA Ffrench-Constant R.H.;
RT "Rapid virulence annotation (RVA): identification of virulence factors
RT using a bacterial genome library and multiple invertebrate hosts.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:15967-15972(2008).
RN [2] {ECO:0000313|EMBL:CAQ82282.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC43949 {ECO:0000313|EMBL:CAQ82282.1};
RA Crossman L.C.;
RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CAR67199.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 43949 {ECO:0000313|EMBL:CAR67199.1};
RA Thomson N.R.;
RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CAQ82282.1, ECO:0000313|Proteomes:UP000002747}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43949 / 3105-77 {ECO:0000313|Proteomes:UP000002747}, and
RC ATCC43949 {ECO:0000313|EMBL:CAQ82282.1};
RX PubMed=19583835; DOI=10.1186/1471-2164-10-302;
RA Wilkinson P., Waterfield N.R., Crossman L., Corton C.,
RA Sanchez-Contreras M., Vlisidou I., Barron A., Bignell A., Clark L.,
RA Ormond D., Mayho M., Bason N., Smith F., Simmonds M., Churcher C.,
RA Harris D., Thompson N.R., Quail M., Parkhill J., ffrench-Constant R.H.;
RT "Comparative genomics of the emerging human pathogen Photorhabdus
RT asymbiotica with the insect pathogen Photorhabdus luminescens.";
RL BMC Genomics 10:302-302(2009).
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DR EMBL; FM162591; CAQ82282.1; -; Genomic_DNA.
DR EMBL; FM211052; CAR67199.1; -; Genomic_DNA.
DR AlphaFoldDB; B6VM19; -.
DR STRING; 291112.PAU_00189; -.
DR KEGG; pay:PAU_00189; -.
DR eggNOG; COG2368; Bacteria.
DR Proteomes; UP000002747; Chromosome.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR Gene3D; 1.10.3140.10; 4-hydroxybutyryl-coa dehydratase, domain 1; 1.
DR Gene3D; 2.40.110.10; Butyryl-CoA Dehydrogenase, subunit A, domain 2; 1.
DR Gene3D; 1.20.140.10; Butyryl-CoA Dehydrogenase, subunit A, domain 3; 1.
DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR InterPro; IPR036250; AcylCo_DH-like_C.
DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom_sf.
DR InterPro; IPR024677; HpaB/PvcC.
DR InterPro; IPR004925; HpaB/PvcC/4-BUDH.
DR InterPro; IPR024719; HpaB/PvcC/4-BUDH_C.
DR InterPro; IPR024674; HpaB/PvcC/4-BUDH_N.
DR PANTHER; PTHR36117; 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED; 1.
DR PANTHER; PTHR36117:SF3; 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED; 1.
DR Pfam; PF03241; HpaB; 1.
DR Pfam; PF11794; HpaB_N; 1.
DR PIRSF; PIRSF500125; 4_HPA_large; 1.
DR PIRSF; PIRSF000331; HpaA_HpaB; 1.
DR SUPFAM; SSF47203; Acyl-CoA dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF56645; Acyl-CoA dehydrogenase NM domain-like; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR000331-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Monooxygenase {ECO:0000313|EMBL:CAR67199.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:CAQ82282.1}.
FT DOMAIN 23..286
FT /note="HpaB/PvcC/4-BUDH N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11794"
FT DOMAIN 295..494
FT /note="HpaB/PvcC/4-BUDH C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03241"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 162..164
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000331-2"
FT BINDING 203
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000331-2"
SQ SEQUENCE 517 AA; 58548 MW; 2520D3B46912B66A CRC64;
MSDEMKQESP DENNTRITRP LNGKEFLEGL NDGREIWAYG ERIHDIANHP AFQNPARAVA
KLYDALHDPA YRDVLTTATD TGSCGVTHPF FRIPRSQEDL IADRDAIAAW ARISYGWLGR
SPDYKASFLT TLGVNPEFYG DFADNAKTWY TRSQEQVLYW NHALINPPID RHLPADEIGD
VCIHVEKECD DGLIVSGAKV VATGSAITHY NFIGHYGLPI KKREFALVCT LPMNSPGLKL
ICRPSYALAA DKMGSPFDYP LSSRFDENDT IIVLDKVKVP WENIFIYGDV EKTSSFFAEA
GFFHRALLHG VTRLAVKLDF LCGLIIKGVE ATGTQAFRGV QTRVGEVLAW RNMFWAISDA
MVKSPQPWHG DALLPRSEYG MAYRWFMTLG YPRIKEIIEQ DLGSALIYVN SHARDFTNPE
LAPYLNKYVR GSNGYSAVER VKLMKLIWDS IGTEFAGRHE LYERNYSGNH ENIRIELLLT
AQESGLMDQF KGFAEQCMSE YDLHGWIGND FIWPSSR
//
